RESUMEN
Neurologically impaired children have an increased frequency of recurrent pain and irritability that persist in some despite comprehensive evaluation and management of possible pain sources. We hypothesized that visceral hyperalgesia was a source of chronic unexplained irritability and report the outcome of gabapentin treatment in 9 severely neurologically impaired children. Caregivers reported marked improvement after treatment ranging from 3 months to 3 years. Nystagmus in 1 child was the only noted adverse effect. Visceral hyperalgesia may be a source of unexplained irritability in the neurologically impaired child. Symptoms may improve with gabapentin treatment.
Asunto(s)
Aminas/uso terapéutico , Analgésicos/uso terapéutico , Ácidos Ciclohexanocarboxílicos/uso terapéutico , Genio Irritable/efectos de los fármacos , Enfermedades del Sistema Nervioso/complicaciones , Ácido gamma-Aminobutírico/uso terapéutico , Adolescente , Adulto , Niño , Preescolar , Enfermedad Crónica , Femenino , Gabapentina , Humanos , Lactante , Masculino , Inducción de Remisión , Estudios Retrospectivos , Índice de Severidad de la EnfermedadRESUMEN
The purpose of this study was to investigate the clinical safety of sodium valproate and total and unbound valproic acid plasma concentrations after rapid infusion in hospitalized, acutely ill children. Four children (5-15 years) completed the study. Sodium valproate doses (8.3-15.4 mg/kg) were administered in Asunto(s)
Anticonvulsivantes/administración & dosificación
, Epilepsia Parcial Compleja/tratamiento farmacológico
, Epilepsia Generalizada/tratamiento farmacológico
, Epilepsia Tónico-Clónica/tratamiento farmacológico
, Ácido Valproico/administración & dosificación
, Enfermedad Aguda
, Adolescente
, Anticonvulsivantes/efectos adversos
, Anticonvulsivantes/farmacocinética
, Niño
, Preescolar
, Relación Dosis-Respuesta a Droga
, Esquema de Medicación
, Quimioterapia Combinada
, Epilepsia Parcial Compleja/sangre
, Epilepsia Parcial Compleja/diagnóstico
, Epilepsia Generalizada/sangre
, Epilepsia Generalizada/diagnóstico
, Epilepsia Tónico-Clónica/sangre
, Epilepsia Tónico-Clónica/diagnóstico
, Femenino
, Semivida
, Humanos
, Infusiones Intravenosas
, Masculino
, Tasa de Depuración Metabólica/fisiología
, Resultado del Tratamiento
, Ácido Valproico/efectos adversos
, Ácido Valproico/farmacocinética