Can S-100B serum protein help to save cranial CT resources in a peripheral trauma centre? A study and consensus paper.

BACKGROUND: Cranial CT (CCT) is the gold standard to rule out traumatic brain injury. The serum level of the protein S-100B has recently been proposed as promising marker of traumatic brain injury. We prospectively investigated whether it might be a reliable tool for CCT triage in mild brain injury at a peripheral trauma centre with limited CT resources. METHODS: Patients with mild head injury and a Glasgow Coma Score of 13-15 admitted to the emergency department of a peripheral trauma centre were enrolled. Blood samples for S-100B analysis were obtained after clinical evaluation. The cut-off level for positive S-100B was 0.105 µg/l. All patients underwent CCT. The relationship between clinical findings, CCT results and S-100B levels was evaluated. RESULTS: 233 patients were enrolled. Median time between injury and sampling was 137 min. CCT was positive in 22 (9%) patients. Of these, 19 (8%) had positive serum S-100B levels. Overall, S-100B had a specificity of 12.2% and a sensitivity of 86.4%, with a positive predictive value of 12.8% and a negative predictive value of 85.7% as a selection tool for CCT triage in patients with mild head injury. CONCLUSION: The S-100B serum level showed a high sensitivity and negative predictive value in the screening of patients with mild head injury. The use of serum S-100B as a biomarker for CCT triage may improve patient screening and decrease the number of CCT scans performed. This would reduce unnecessary radiation exposure and free up capacity in the emergency rooms of peripheral hospitals to enable them to cope better with multiple admissions.

Randomized clinical trial of Lichtenstein's operation versus mesh plug for inguinal hernia repair.

BACKGROUND: Two of the most commonly used open prosthetic tension-free techniques for inguinal hernia repair are Lichtenstein's operation and the mesh plug repair. The technique of choice remains a subject of ongoing debate. The objective of the present investigation was to compare the two surgical procedures with respect to associated morbidity and recurrence rates. METHODS: Five hundred and ninety-five patients with 700 primary or recurrent inguinal hernias were randomized to undergo either Lichtenstein's operation or mesh plug repair. The primary endpoint of the investigation was the recurrence rate 1 year after surgery. Secondary endpoints were perioperative complications and reoperation rates. RESULTS: At 12-month follow-up, 597 hernia repairs (85.3 per cent) were evaluated. There were no significant differences regarding recurrence rates and perioperative complications. However, there was a significant difference in the overall reoperation rate between the two treatment groups, with 13 reoperations (4.2 per cent) in the Lichtenstein group and four (1.4 per cent) in the mesh plug group (P = 0.047). CONCLUSION: Lichtenstein's operation and the mesh plug repair are comparable with respect to perioperative complications and recurrence rates.

[Massive gastrointestinal hemorrhage with anastomosis rupture in pseudoaneurysm of the common hepatic artery follow pancreaticoduodenectomy. An unusual, severe complication]. / Massive Gastrointestinalblutung mit Anastomosenruptur bei Pseudoaneurysma der A. hepatica communis nach Pancreato-Duodenektomie. Eine ungewöhnliche, schwerwiegende Komplikation.

Surgery of pancreatic and biliary tract carcinomas includes an extensive surgical dissection with removal of all neural and lymphoid tissue together with a skeletonization of hepatoduodenal structures. Skeletonization or autodigestion may lead to pseudaneurysms of perihepatic arteries. Rupture of one of these aneurysms may cause a severe upper gastrointestinal bleeding. Only a few cases of these serious complications are reported in literature.