Oncocytoma in adrenal gland.

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Association of Metformin and Abdominal Aortic Aneurysm Repair Outcomes.

BACKGROUND: Metformin is a commonly used drug in diabetes mellitus treatment. Recently it has been suggested that the use of metformin on diabetes mellitus patients may lower the prevalence and slow the progression of AAA (abdominal aortic aneurysm) as well as the risk of rupture related mortality. The aim of this studywas to investigate the impact of metformin treatment on the risk of AAA repair related mortality and surgical complications. METHODS: In this retrospective study, the clinical data of 306 patients, including 77 patients with diabetes mellitus, who underwent abdominal aortic aneurysm repair has been analyzed. Treatment outcomes have been investigated. The diabetes and metformin prescription status has been obtained from the medical history. Patients were divided into three groups: diabetes-free individuals, diabetics treated with metformin and diabetics treated with other glucose lowering drugs. The association between metformin treatment and AAA diameter, surgical complications and mortality were assessed using chi-square independence test and odds ratio analysis. In order to assess which factors are influencing AAA repair related complications and mortality a multi-variables analysis has been performed. RESULTS: A significant protective effect of metformin treatment towards AAA repair related mortality (P = 0.019) and complications (P = 0.032) among patients suffering from diabetes mellitus was revealed. These findings were statistically insignificant when considering all groups of patients (diabetes-free individuals, diabetics treated with metformin and diabetics treated with other glucose lowering drugs). CONCLUSION: Metformin may lower the risk of AAA repair related mortality and surgical complications among patients with diabetes.

[Infections with hepatitis B virus in hemodialysis units of Wielkopolska]. / Zakazenia wirusem zapalenia watroby typu B w wielkopolskich stacjach hemodializ.

OBJECTIVE: Epidemiological analysis of HBV infections in dialysis units of Wielkopolska. METHODS: Studies were carried out in 19 dialysis units, in which patients were treated with intermittent hemodialysis (IHD). Data were collected from 18.04.2007 to 18.06.2007. MAIN OBSERVATIONS: There were 39 persons with HBsAg(+) among 1140 patients (3.42%). Positive results of HBcAb were shown in 114 from 349 examined patients with HBsAg(-) (32.7%). The group with HBsAg(+) consisted of 7 women (17.9%) and 32 men (82.1%). Documented duration of HBV infection was 9.7 +/- 6.0 years. Eight patients before detection of HBsAg(+) were vaccinated against hepatitis B; 21 patients (53.8%) underwent surgical interventions or invasive diagnostic procedures. Transfusions of blood or blood-related products were documented in 17 cases (43.6%). HBV infection in at least 32 patients (82.1%) was not connected with IHD treatment (p = 0.000). Four patients (10.3%) showed symptoms of acute hepatitis. Eleven patients (28.2%) with HBsAg(+) had renal transplantation. Patients with HBsAg(-) were vaccinated against hepatitis B. Vaccination was not effective (level of HBsAb < 10 IU/l) in 244 patients (22.2%). CONCLUSIONS: HBV infection in patients with chronic kidney disease is most frequently detected before or due to initiation of IHD treatment. Over 20% IHD patients remains susceptible for HBV infection despite vaccination against hepatitis B.