IARC TP53 mutation database

This database includes all TP53 gene mutations identified in human cancers and published in the peer-reviewed literature.

European Network of Cancer Registries - ENCR.

It presents information on incidence and mortality from cancer in the European Union, allows access to cancer database (EUCAN), and allows downloads of recommendations for cancer registries.

Useful links on TP53

It provides links on TP53 mutation: Meetings and events, definitions and function, clinical information, sequencing methods, Other TP53 mutation databases and resources, related proteins and information on cancer and tumor genes.

TP53 mutation databases

Downloadable database which provides a description of the mutation, an identification of the biological sample in which it was found, informations on the individual from whom the sample has been isolated and references the publication in which the mutation was originally described. Microsoft Access or File Maker Pro are needed.

Polymorphisms In The TP53 Gene

It presents lists of polymorphisms which do alter and do not alter the amino acid sequence of P53, and polymorphisms in non coding regions of the P53 gene.

Species difference in thyroid, kidney and urinary bladder carcinogenesis.

It examines the scientific basis for possible species differences in mechanisms by which thyroid follicular-cell tumours in mice and rats, renal tubule-cell tumours in male rats and urinary bladder tumours in rats may be produced.

The use of short- and medium-term tests for carcinogens and data on genetic effects in carcinogenic hazard evaluation.

It evaluates the use of short- and medium-term assays with end-points of neoplasia or lesions that are precursors to neoplasia, and attempts to define the role of data from genetic toxicology in the prediction of carcinogenic hazard.

Mechanisms of fibre carcinogenesis.

It addresses the strengths, weaknesses and gaps in the present knowledge on genotoxicity, fibre characterization, cell proliferation and activation, and animal studies, and provides answers to specific questions on the relevance of mechanistic data from in-vitro and in-vivo assays in the assessment of the carcinogenic risk of fibres to humans.

Peroxisome proliferation and its role in carcinogenesis.

It discusses the characteristics of peroxisome proliferation, hepatocarcinogenicity in experimental animals, peroxisome proliferation as a biological marker for hepatocarcinogenesis, and peroxisome proliferators, human response and hazard.

Resources for cancer registries

It presents 104 abstracts of projects (randomised intervention trials covering areas of primary prevention, chemoprevention and secondary prevention) carried out in 31 countries.

IARC Monographs, volume 69: polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans - summary of data reported and evaluation.

It presents data reported and results of carcinogenicity evaluation for humans and animals of polychlorinated dibenzo-para-dioxins and dibenzofurans.

IARC Monographs, volume 70: Epstein-Barr virus and Kaposi´s sarcoma herpesvirus / human herpesvirus 8 - summary of data reported and evaluation.

It presents data reported and results of carcinogenicity evaluation for humans and animals of some viruses.

IARC Monographs, volume 71: re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide - summary of data reported and evaluation.

It presents data reported and results of carcinogenicity evaluation for humans and animals of some organic chemicals, hydrazine and hydrogen peroxide.

IARC Monographs, volume 72: hormonal contraception and post-menopausal hormonal therapy - summary of data reported and evaluation.

It presents data reported and results of carcinogenicity evaluation for humans and experimental animals of oral contraceptives, progestogens, and oestrogen.

IARC Monographs, volume 73: some chemicals that cause tumours of the kidney or urinary bladder in rodents and some other substances - summary of data reported and evaluation.

It presents data reported and results of carcinogenicity evaluation for humans and experimental animals of some chemical compounds.

IARC Monographs, volume 74: surgical implants and other foreign bodies - summary of data reported and evaluation.

It presents data reported and results of carcinogenicity evaluation for humans and experimental animals of surgical implants and other foreign bodies.

IARC Monographs, volume 75: ionizing radiation, part 1: X- and Gamma (y)-radiation, and neutrons - summary of data reported and evaluation.

It presents data reported and results of carcinogenicity evaluation for humans and animals of ionizing radiation.

IARC Monographs, volume 76: some antiviral and antineoplastic drugs, and other pharmaceutical agents - summary of data reported and evaluation.

It presents data reported and results of carcinogenicity evaluation for humans and animals of some antiviral and antineoplastic drugs.

IARC Monographs, volume 77: some industrial chemicals - summary of data reported and evaluation.

It presents data reported and results of carcinogenicity evaluation for humans and animals of some industrial chemicals.

Overall evaluations of carcinogenicity: an updating of IARC Monographs volume 1 to 42 - supplement 7.

It presents updating of the IARC carcinogenicity evaluations for several chemical compounds (from Acetamide to Vinyl chloride).