[Cost-effectiveness analysis of Chaiyin Granules in treatment of influenza].

This study aimed to evaluate the cost-effectiveness of Chaiyin Granules compared with Oseltamivir Phosphate Capsules in the treatment of influenza(exogenous wind-heat syndrome). Based on a randomized, double-blind, positive drug parallel control clinical trial, this study evaluated the pharmacoeconomics of Chaiyin Granules with cost-effectiveness analysis method. A total of 116 patients with influenza from eight hospitals(grade Ⅱ level A above) in 6 cities were selected in this study, including 78 cases in the experimental group with Chaiyin Granules and Oseltamivir Phosphate Capsules placebo, and 38 cases in the control group with Oseltamivir Phosphate Capsules and Chaiyin Granules placebo. The total cost of this study included direct medical cost, direct non-medical cost, and indirect cost. The remission time of clinical symptoms, cure time/cure rate, antipyretic onset time/complete antipyretic time, viral nucleic acid negative rate, and traditional Chinese medicine(TCM) syndrome curative effect were selected as the effect indicators for cost-effectiveness analysis. Four-quadrant diagram was used to estimate the incremental cost-effectiveness ratio. The results showed that Chaiyin Granules were not inferior to Oseltamivir Phosphate Capsules in the remission time of clinical symptoms of influenza(3.1 d vs 2.9 d, P=0.360, non-inferiority margin was 0.5 d). Compared with Oseltamivir Phosphate Capsules, Chaiyin Granules would delay the remission time of clinic symptoms of influenza for 1 d, but could save 213.9 yuan. 1 d delay in cure time could save 149.3 yuan; 1% reduction in the cure rate could save 8.2 yuan; 1 d delay in antipyretic onset time could save 295.4 yuan; 1 d delay in complete antipyretic time could save 114.3 yuan; 1% reduction in the 5-day cure rate of TCM syndrome could save 19.2 yuan. Different from other indicators, there was no statistically significant difference between two groups in the effect of negative conversion rate of viral nucleic acid, but the cost was lower and the effect was superior, and the pharmacoeconomics was not different from that of Oseltamivir Phosphate Capsules in the field of influenza treatment.

Assessment of General Populations Knowledge, Attitude, and Perceptions Toward the Coronavirus Disease (COVID-19): A Cross-Sectional Study From Pakistan.

Background: Coronavirus disease 2019 (COVID-19) is a global health threat and caused a universal psychosocial impact on the general population. Therefore, the knowledge, attitude, and perceptions (KAPs) of the general population are critical for the development and effective implementation of standard operating procedures (SOP) to contain the contagion and minimize the losses. Therefore, the current study was conducted to understand and evaluate the KAPs of Pakistani populations toward the COVID-19. Methods: An online cross-sectional study was carried out among participants from 1 May to 30 July 2020 in different areas of Pakistan. The respondents of the study were the general population with age ≥ 18 years. The poll URL was posted on several channels after a call for participation. Other social media platforms such as WeChat, WhatsApp, Facebook, Twitter, Instagram, Messenger, and LinkedIn were engaged to maximize general population engagement. The questionnaire included details about sociodemographic, knowledge about COVID-19, perceptions toward universal safety precautions of COVID-19, and beliefs attitude toward the COVID-19. The obtained data were exported into a Microsoft Excel spreadsheet and SPSS software version 21 for windows. The descriptive statistics values were presented in frequencies and percentages. Binary logistic regression, Chi-square test, and one-way ANOVA were applied to analyze the participants' socio-demographic characteristics and variables related to KAPs. P-value < 0.05 was recorded as significant. Results: A total of 1,000 participants were invited of which 734 participated in this study. The response rate was 73.4% (734/1,000). The gender, marital status, education, and residence showed a significant association with the knowledge score. The majority of the study participants were thinking that COVID-19 may be more dangerous in elderly individuals 94.5% (n = 700), and individuals with chronic diseases or severe complications 96.7% (n = 710) (p = 0.00). More than half of the participants 52.5% (n = 385) showed their concern that either they or their family members might get the infection. More than 98% (n = 703), (P-value = 0.00) of the participants held that COVID-19 would be successfully controlled in Pakistan by following the standard SOPs and government guidelines. Conclusion: This study showed that the general population of Pakistan has good awareness and reasonable attitudes and perceptions toward the full features of the COVID-19. The current study suggests that mass-level effective health education programs are necessary for developing countries to improve and limit the gap between KAP toward COVID-19.

[Optimizing vegetation pattern for the riparian buffer zone along the lower Yellow River based on slope hydrological connectivity]. / åŸºäºŽå¡é¢æ°´æ–‡è¿žé€šæ€§çš„é»„æ²³ä¸‹æ¸¸æ²³å²¸ç¼“å†²å¸¦æ¤è¢«æ ¼å±€ä¼˜åŒ–.

Riparian buffer zone is important ecological transitional region between river and upland. Restoring the degraded vegetation system is important for preventing soil erosion, improving ecological environment and helping to achieve the sustainable development of ecosystems. Based on the scenario simulation of vegetation pattern and flow length index, we analyzed the responses of hydrological connectivity to vegetation pattern under different vegetation coverages and slope gradients, and explored the optimal vegetation pattern of soil and water conservation in riparian buffer zone in the lower reaches of the Yellow River. The results showed that the midslope-coarsness-clustered distribution of vegetation configuration, which exhibited the shortest flow length and the weakest hydrological connectivity, being the optimal vegetation pattern for controlling slope runoff generation and flow concentration. For the optimal vegetation pattern, its flow length increased with increasing slope length, namely, the longer slope length the more significant difference of hydrological connectivity between different slope gradients. Meanwhile, flow length of the optimal vegetation pattern decreased with increasing vegetation coverage. The differences between different slope gradients were obvious under low vegetation coverage, while it was unobvious on slope with vegetation coverage of 45%. Compared with the irregular variation trend of flow length on the actual vegetation slope, there was a consistent trend of first increase and then decrease on the simulated slope with the optimal vegetation pattern. Within the pre-set slope gradient range (5°-20°), the optimal vegetation pattern changed the variation of flow length between different slope gradients in the process of coverage change, which highlighted the influence of riparian buffer zone vegetation pattern on hydrological connectivity.

[Characteristics of CO2 flux and its influence factors over winter wheat agroecosystem in the North China Plain]. / 华北平原冬小麦农田生态系统CO2é€šé‡ç‰¹å¾åŠå ¶å½±å“å› ç´ .

Using CO2 flux data of winter wheat recorded by eddy covariance system, combined with the meteorological data, we examined the diurnal variations of CO2 fluxes in four growth stages (tillering stage, overwintering stage, jointing stage and filling stage) of winter wheat in an agroecosystem of the North China Plain from 2013 to 2014. The seasonal variation of net ecosystem exchange and its relationship with meteorological factors were investigated. The results showed that the net ecosystem exchange in the whole growing season was -360.15 g C·m-2. The gross primary productivity in the whole growing season was 1920.01 g C·m-2. The winter wheat agroecosystem had strong capacity in carbon sequestration. The CO2 fluxes showed an obvious diurnal and seasonal variation characteristics in winter wheat agroecosystem. This ecosystem was a carbon source in tillering stage, while it was a carbon sink in overwintering stage, jointing stage and filling stage. The mean value of apparent initial light energy utilization was 0.03 mg CO2·µmol-1. The mean value of ecosystem production was 1.53 mg CO2·m-2·s-1 when light was saturated. The monthly average value of ecosystem respiration was 193.92 g C·m-2·month-1. The net ecosystem exchange and photosynthetically active radiation had a significant correlation in four growth stages of winter wheat. The correlations between net ecosystem exchange and vapor pressure deficit were significant in all the growth stages. There was a positive correlation between daily total net ecosystem exchange and soil temperature in tillering stage, overwintering stage and filling stage, but a negative correlation between them in jointing stage.

[Flux footprint of winter wheat farmland ecosystem in the North China Plain]. / 华北平原冬小麦农田生态系统通量贡献区.

The flux data of winter wheat farmland ecosystem observed by eddy covariance system in the North China Plain from 2013 to 2014 were used to combine with the footprint model FSAM. The temporal and spatial distributions of footprint of winter wheat farmland ecosystem in the North China Plain were analyzed. The differences of footprint distribution in different atmospheric stratification and growing seasons were contrastively studied. The results indicated that in the predominant wind direction, the source areas of stable atmospheric stratification were larger than unstable atmospheric stratification during the growing season of winter wheat. When the wind direction was between 0°-90°, the source area of stable atmospheric stratification was about 17.8 m longer than unstable atmospheric stratification in initial growing season. The source area of stable atmospheric stratification was about 11 m longer than unstable atmospheric stratification in late growing season. The location of the maximum flux footprint in initial growing season was 15 m (stable atmospheric stratification) and 12.4 m (unstable atmospheric stratification) further away from the observing tower than late growing season, respectively. Meanwhile, the location of the maximum flux footprint in stable atmospheric stratification was 5 m (initial growing season) and 2.4 m (late growing season) further away from the observing tower than unstable atmospheric stratification, respectively. When the wind direction was non-dominant between 90°-180°, the location of the maximum flux footprint in diffe-rent growing seasons and atmospheric stratification were 67.8 and 53.4, 47.0 and 30.8 m away from the observing tower, respectively. When the wind direction was between 270°-360°, the location of the maximum flux footprint in different growing seasons and atmospheric stratification were 58.8 and 42.0, 41.1 and 33.1 m away from the observing tower, respectively. The flux information was mainly from the northeast, southwest and southeast, which accounted for 35.4%, 32.5% and 19.4% of the whole gro-wing season scale, respectively. The major changes of flux footprint in the whole gro-wing season of winter wheat were observed from 16.0 to 173.8 m in the northeast and from 14.7 to 209 m in the southwest. The flux information was all from the farmland ecosystem. The characteristics of diurnal variations of flux footprint in two typical dates were obvious. The source area changed with atmospheric stratification and wind direction. The flux information was all from farmland ecosystem at night, while little flux information was from residential area and orchard at daytime. The quantitative results of this study could provide basis for the research of flux footprint in farmland ecosystem.