Changes of circulating CD4(+)CD25(+)CD127(low) regulatory T cells in patients with acute coronary syndrome and its significance.

The aim of this study was to investigate the changes of circulating CD4(+)CD25(+)CD127(low) regulatory T cells (Treg) in patients with acute coronary syndrome (ACS) and its significance. The experiment was divided into three groups: ACS (48 patients), stable angina pectoris (SAP) (24 patients), and normal controls (24 subjects). The CD4(+)CD25(+)CD127(low) Treg cell counts were tested by flow cytometry, and the levels of high-sensitivity C-reactive protein (hs-CRP) and peripheral blood leukocytes (PWBCs) were determined in the peripheral blood of each group; comparisons were made among groups. The frequency of CD4(+)CD25(+)CD127(low) to CD4(+) cell in the ACS group (3.18 ± 1.76%) was significantly lower than those observed in control (5.64 ± 1.63%) and SAP (5.60 ± 1.56%) groups (F = 25.247, P < 0.01), while the hs-CRP and PWBC levels in the ACS group were significantly higher than those in the control group (P < 0.05). In addition, the reduced frequency of CD4(+)CD25(+)CD127(low) to CD4(+) cells was negatively correlated with the increased hs-CRP and PWBC counts by correlation analysis, and the related coefficients (r) were -0.518 and -0.311, respectively (P < 0.01). These findings indicate that the decrease of the frequency of Treg cells in the peripheral blood of patients with ACS might destroy the balance of tolerance of the peripheral immune system and might activate inflammation, thus participating in the occurrence and development of the pathological processes of atherosclerosis.

Impact of Comprehensive Rehabilitation Therapy on Trunk Controlling Ability of Children with Cerebral Palsy.

OBJECTIVE: This study aims to investigate the impact of comprehensive treatment on the trunk controlling ability (TCA) of children with cerebral palsy (CPC). METHODS: Twenty children with spastic cerebral palsy had truncal stability parameters in the sitting posture and the symmetry parameters of left-right-forward-backward centre of pressure evaluated by the stationary stability assessment module of the PK 254 P balance training instrument. After a six-month trunk control training with physical therapy technology and balancing instrument, the above indicators were re-evaluated, and the evaluations before and after the treatment were analysed to assess the therapeutic effect. RESULTS: The difference in the truncal stability parameters before and after the treatment was statistically significant (p < 0.05); the difference in the symmetry parameters of forward-backward centre of pressure was significant (p < 0.05). CONCLUSIONS: The balancing instrument training, combined with physical therapy technology training, could effectively improve the TCA of CPC, and the balancing instrument could also provide the objective and quantitative efficacy assessment toward the TCA of CPC.