Epidemiology of Takayasu arteritis in Shanghai: A hospital-based study and systematic review.

BACKGROUND: Takayasu arteritis (TAK) is a rare large vessel vasculitis, and epidemiological data on TAK are lacking in China. Thus, we designed this study to estimate the TAK prevalence and incidence in residential Shanghai, China. METHODS: Data on diagnosed TAK cases aged over 16 years were retrieved from 22 tertiary hospitals in Shanghai through hospital electronic medical record systems between January 1, 2015 and December 31, 2017 to estimate the prevalence and incidence. A systematic literature review based on searches in PubMed, Ovid-Medline, Excerpta Medica Database (EMBASE), Web of Science, and China National Knowledge Infrastructure (CNKI) was performed to summarize TAK distribution across the world. RESULTS: In total 102 TAK patients, with 64% female, were identified. The point prevalence (2015-2017) was 7.01 (95% CI 5.65-8.37) cases per million, and the mean annual incidence was 2.33 (1.97-3.21) cases per million. The average age of TAK patients was 44 ± 16 years, with the highest prevalence (11.59 [9.23-19.50] cases per million) and incidence (3.55 [0.72 3.74] cases per million) in the 16 to 34 years population. Seventeen reports were included in the system review, showing that the epidemiology of TAK varied greatly across the world. The incidence and prevalence were both relatively higher in Asian countries, with the prevalence ranging 3.3-40 cases per million and annual incidence ranging 0.34-2.4 cases per million. CONCLUSIONS: The prevalence and incidence of TAK in Shanghai was at moderate to high levels among the previous reports. The disease burden varied globally among racial populations.

Technique of radiologic measurements for the inner ear structures using computed tomography / 中华耳鼻咽喉头颈外科杂志

<p><b>OBJECTIVE</b>The aim of this study was to find an accurate and feasible measurement technique for the inner ear structures using computed tomography and to check the inter-observer agreement</p><p><b>METHODS</b>Sixty patients without abnormal structure of temporal bones confirmed by means of high-resolution computed tomography were included in this study. The multi-planar reformations (MPR) were performed to show the maximum profile of cochlear, and to measure the height and width of cochlear. Areas of bony island encircled by three semicircular canals were measured on the MPR images that could show the whole canal. The data measured by two readers independently was compared to check the inter-observer agreement.</p><p><b>RESULTS</b>The application of MPR yielded satisfactory anatomic presentation of inner ear for radiologic measurements. There was good inter-observer agreement revealed by the paired t-test and correlation analysis (P>0.05, r>0.9). The height of cochlear (x+/-s) was (4.26+/-0.28) mm while the width of cochlear was (7.03+/-0.39) mm. The areas of bony islands encircled by the anterior, posterior and lateral semicircular canals were (25.49+/-3.84) mm2, (20.07+/-2.93) mm2 and (11.50+/-1.94) mm2, respectively.</p><p><b>CONCLUSIONS</b>MPR can display structures of cochlear and semicircular canals on planes along their central axis. Normative measurements on these MPR images derive excellent repeatability and provide reliable morphologic parameters of inner ear structures.</p>