RESUMEN
The technology of CO2-enhanced gas recovery (CO2-EGR) plays a pivotal role in the CCUS (Carbon Capture, Utilization, and Storage) industry, which helps to achieve a win-win situation of economic benefit and environmental benefit for gas fields. Shale gas reservoirs, with their unique geological and surface engineering advantages, are one of the most promising options for CCUS implementation. Focusing on shale formations within the mid-deep blocks of the Sichuan Basin, this study conducted competitive adsorption experiments using multicomponent gases. Through physical simulations and single-well numerical modeling, factors such as injection volume, timing, shut-in time, and huff-n-puff rounds were examined for their impact on recovery. The results show that the higher the CO2 content in the injected medium, the more pronounced advantage in gas adsorption on shale surfaces. Optimal performance was achieved with a CO2 content in the injection medium of 80% to 100%, an injection volume of 0.2-0.3 PV, a shut-in time exceeding 6 h, and a relatively delayed injection timing. The recovery in the first round of huff-n-puff was increased by 24.2% to 47.8%, which gave a full play to the role of huff-n-puff and achieved favorable benefits. Based on the middle-deep geological parameters, a single-well numerical simulation was established, which demonstrates that single-well EUR (estimated ultimate recovery) can be increased by 14.2% to 19.8% compared to gas wells without CO2 injection. This study provides essential guidance for the enhanced recovery in shale gas reservoirs through CO2 huff-n-puff.
RESUMEN
Anti-seizure drugs (ASDs) are the first choice for the treatment of epilepsy, but there is still one-third of patients with epilepsy (PWEs) who are resistant to two or more appropriately chosen ASDs, named drug-resistant epilepsy (DRE). Temporal lobe epilepsy (TLE), a common type of epilepsy usually associated with hippocampal sclerosis (HS), shares the highest proportion of drug resistance (approximately 70%). In view of the key role of the temporal lobe in memory, emotion, and other physiological functions, patients with drug-resistant temporal lobe epilepsy (DR-TLE) are often accompanied by serious complications, and surgical procedures also yield extra considerations. The exact mechanisms for the genesis of DR-TLE remain unillustrated, which makes it hard to manage patients with DR-TLE in clinical practice. Animal models of DR-TLE play an irreplaceable role in both understanding the mechanism and searching for new therapeutic strategies or drugs. In this review article, we systematically summarized different types of current DR-TLE models, and then recent advances in mechanism investigations obtained in these models were presented, especially with the development of advanced experimental techniques and tools. We are deeply encouraged that novel strategies show great therapeutic potential in those DR-TLE models. Based on the big steps reached from the bench, a new light has been shed on the precise management of DR-TLE.