1.
J Org Chem
; 88(9): 6146-6158, 2023 May 05.
Artículo
en Inglés
| MEDLINE
| ID: mdl-37022671
RESUMEN
Here, we report an anionic stereogenic-at-cobalt(III) complex catalysis strategy for the enantioselective halocyclization of ortho-alkynylanilines using N-halosuccinimide (NXS) as the halogen source. This protocol provides a distinct atroposelective approach to access the axially chiral ortho-halo-C2-indole skeletons in excellent yields with good to high enantioselectivities (up to 99% yield, 99:1 er).