RESUMEN
In order to improve the accuracy of air pollution management and promote the efficiency of coordinated inter-regional prevention and control, this study analyzes the interaction of O3 in Qilihe District, Lanzhou City, China. Data used for analysis was obtained from 63 air quality monitoring stations between November 2017 and October 2018. This paper uses complex network theory to describe the network structure characteristics of O3 pollution spatial correlation. On this basis, the node importance method is used to mine the sub-network with the highest spatial correlation in the O3 network, and use transfer entropy theory to analyse the interaction of pollutants between regions. The results show that the O3 area of Qilihe District, Lanzhou City can be divided into three parts: the urban street community type areas in urban areas, the township and village type areas in mountain areas and the scattered areas represented by isolated nodes. An analysis of the mutual influence of O3 between each area revealed that the impact of O3 on each monitoring station in adjacent areas will vary considerably. Therefore these areas cannot be governed as a whole, and the traditional extensive management measures based on administrative divisions cannot be used to replace all other regional governance measures. There is the need to develop a joint prevention and control mechanism tailored to local conditions in order to improve the accuracy and efficiency of O3 governance.
RESUMEN
Glioblastoma is one of the most frequent and aggressive primary tumor of glial brain tumors. Long non-coding RNA Prostate cancer-associated ncRNA transcript 6 (PCAT6) has been identified to influence the progression of many cancers, but its expression and functions in glioblastoma remain unclear. In this study, we intended to investigate the expression, functions and the corresponding mechanisms of PCAT6 in glioblastoma. We observed that PCAT6 expression was upregulated in glioblastoma tissues and cell lines and its high expression was due to the transcriptional activation by Yin Yang 1. miR-513 was a target of PCAT6 and Insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1) was a target of miR-513. Hence, PCAT6 upregulated IGF2BP1 expression via miR-513 in a competing endogenous RNAs manner. PCAT6 and IGF2BP1 functioned as oncogenes while miR-513 acted as a tumor suppressor gene in glioblastoma. PCAT6 and miR-513 modulated the proliferation and survival of glioblastoma cells via AKT signaling by mediating IGF2BP1. IGF2BP1 raised the expression of PCAT6 by increasing its stability. In conclusion, our results indicate that PCAT6/miR-513/IGF2BP1 positive feedback loop plays a crucial role in facilitating glioblastoma progression.
