Patient-derived organoids in human cancer: a platform for fundamental research and precision medicine.

Cancer is associated with a high degree of heterogeneity, encompassing both inter- and intra-tumor heterogeneity, along with considerable variability in clinical response to common treatments across patients. Conventional models for tumor research, such as in vitro cell cultures and in vivo animal models, demonstrate significant limitations that fall short of satisfying the research requisites. Patient-derived tumor organoids, which recapitulate the structures, specific functions, molecular characteristics, genomics alterations and expression profiles of primary tumors. They have been efficaciously implemented in illness portrayal, mechanism exploration, high-throughput drug screening and assessment, discovery of innovative therapeutic targets and potential compounds, and customized treatment regimen for cancer patients. In contrast to conventional models, tumor organoids offer an intuitive, dependable, and efficient in vitro research model by conserving the phenotypic, genetic diversity, and mutational attributes of the originating tumor. Nevertheless, the organoid technology also confronts the bottlenecks and challenges, such as how to comprehensively reflect intra-tumor heterogeneity, tumor microenvironment, tumor angiogenesis, reduce research costs, and establish standardized construction processes while retaining reliability. This review extensively examines the use of tumor organoid techniques in fundamental research and precision medicine. It emphasizes the importance of patient-derived tumor organoid biobanks for drug development, screening, safety evaluation, and personalized medicine. Additionally, it evaluates the application of organoid technology as an experimental tumor model to better understand the molecular mechanisms of tumor. The intent of this review is to explicate the significance of tumor organoids in cancer research and to present new avenues for the future of tumor research.

The antiferroptotic role of TRIM7: Molecular mechanism and synergistic effect with temozolomide.

Nuclear receptor coactivator 4 (NCOA4) protein is a selective cargo receptor that plays a crucial role in ferritinophagy by targeting and delivering the ferritin iron storage protein to lysosomes for degradation and releasing iron. TRIM7 overexpression inhibits ferroptosis in glioblastoma cells by ubiquitinating NCOA4 protein.

Targeting the ferroptosis crosstalk: novel alternative strategies for the treatment of major depressive disorder.

Depression is a major contributor to poor global health and disability, with a recently increasing incidence. Although drug therapy is commonly used to treat depression, conventional antidepressant drugs have several disadvantages, including slow onset, low response rates and severe adverse effects. Therefore, developing effective therapies for depression remains challenging. Although various aetiological theories of depression exist, the underlying mechanisms of depression are complex, and further research is crucial. Moreover, oxidative stress (OS)-induced lipid peroxidation has been demonstrated to trigger ferroptosis. Both OS and ferroptosis are pivotal mechanisms implicated in the pathogenesis of neurological disorders, and investigation of the mediators involved in these processes has emerged as a prominent and active research direction. One previous study revealed that regulatory proteins involved in ferroptosis are implicated in the pathogenesis of depression, and antidepressant drugs could reverse depressive symptoms by inhibiting ferroptosis in vivo, suggesting an important role of ferroptosis in the pathogenesis of depression. Hence, our current comprehensive review offers an up-to-date perspective on the intricate mechanisms involved, specifically concerning ferroptosis and OS in the context of depression, along with promising prospects for using molecular mediators to target ferroptosis. We delineate the key targets of molecular mediators involved in OS and ferroptosis implicated in depression, most notably reactive oxygen species and iron overload. Considering the pivotal role of OS-induced ferroptosis in the pathogenesis of neurological disorders, delving deeper into the underlying subsequent mechanisms will contribute significantly to the identification of novel therapeutic targets for depression.

Graphene perfect absorber based on degenerate critical coupling of toroidal mode.

Graphene is a two-dimensional material with great potential for photodetection and light modulation applications owing to its high charge mobility. However, the light absorption of graphene in the near-infrared range is only 2.3%, limiting the sensitivity of graphene-based devices. In this study, we propose a graphene perfect absorber based on degenerate critical coupling comprising monolayer graphene and a hollow silicon Mie resonator array. In particular, monolayer graphene achieves perfect absorption by controlling the periods and holes of the Mie resonators. The proposed graphene perfect absorber can significantly improve the sensitivity of graphene-based devices.

All-dielectric perfect absorber based on quadrupole modes.

In principle, the absorbance of a free-standing ultra-thin film is limited to 50%. To overcome this limitation, an all-dielectric perfect absorber is proposed herein based on the concept of degenerate critical coupling (DCC) of quadrupole modes. We study the absorbance of a dielectric elliptic cylinder and find that perfect absorption can be achieved by spectrally overlapping peaks of electric and magnetic quadrupole modes. This suggests that the DCC method can be extended to the quadrupole modes beyond dipole modes. Such an all-dielectric perfect absorber can be used in photodetectors, optical filters, and optical modulators mediated by the photothermal effect.

Radiative loss control of an embedded silicon perfect absorber in the visible region.

The absorbance of a free-standing ultrathin layer is limited to 50%; we overcome this limitation by numerically investigating a wavelength-selective perfect absorber based on Mie resonance and degenerate critical coupling. We extend the wavelength of close-to-unity absorbance to the entire visible region by controlling the radiative loss and intrinsic loss. Radiative loss can be controlled by embedding the Mie resonator into a thin film with the defined refractive index. Meanwhile, intrinsic loss can be controlled by addition of a dielectric cap with a higher extinction coefficient on the Mie resonator. Such all-dielectric perfect absorbers can be applied to efficient photodetectors, imaging sensor pixels, or all-optical switching devices mediated by the photothermal effect.

Terahertz Fano resonances induced by combining metamaterial modes of the same symmetry.

Fano resonances are observed in a composite metamaterial that consists of an electric split ring resonator eSRR and an I-shaped resonator ISR. By adjusting the length of the ISR the degree of asymmetry in the line shape of the composite metamaterial can be controlled and even made to be symmetric. In contrast to other methods to create Fano resonances, the individual modes of the eSRR and ISR have the same symmetry and are not evanescently coupled to each other. The transmission is simulated using the finite difference time domain method and a coupled oscillator model is used to obtain nominal values of the Fano asymmetry factor q. Composite metamaterials and individual eSRR and ISR metamaterials are fabricated, and their transmission is measured with terahertz time-domain spectroscopy.