Safety and efficacy of delayed completion lobectomy following wedge resection vs. segmentectomy-a retrospective cohort study.

Background: Data regarding the safety and efficacy of delayed completion lobectomy (CL) following sublobar resections remain scant. We evaluated the technical difficulty and short-term outcomes of CL occurring at least 3 months following the anatomical segmentectomy or wedge resection. Methods: Consecutive non-small cell lung cancer (NSCLC) patients who underwent a second resection within the same lobe at least 3 months after their initial resection from January 2013 to December 2019 at the Shanghai Pulmonary Hospital were retrospectively included. The patients were divided into a segmentectomy group (SG group) and a wedge resection group (WR group) based on their initial resection strategy. Baseline characteristics and short-term outcomes after CL between the two groups were compared. Results: Twenty-five patients undergoing CL were included, nine in the SG group and 16 in the WR group. No deaths occurred within 30 days postoperatively, and the rate of overall postoperative complications was 28.0% (7/25). Statistically significant differences were found in rates of postoperative complications between the two groups (SG: 55.6% vs. WR: 12.5%, P=0.03) and in the use of bronchoplasty or angioplasty during the CL (SG: 33.3% vs. WR: 0.0%, P=0.04). After CL, no significant differences were found in 5-year recurrence-free survival (RFS) (WR: 66.7% vs. SG: 61.0%, P=0.31) or overall survival (OS) (WR: 93.8% vs. SG: 66.7%, P=0.06) between two groups. Conclusions: Delayed CL occurring over 3 months after sublobar resection is a safe and effective procedure, with no deaths occurring within 30 days postoperatively. As compared to a segmentectomy at the time of the index operation, a wedge resection may portend less morbidity, with a decreased risk of needing adjunctive bronchoplasty or angioplasty procedures during CL. After CL, 5-year RFS and OS were comparable between WR and SG groups.

Insight into Multiple Intermolecular Coordination of Composite Solid Electrolytes via Cryo-Electron Microscopy for High-Voltage All-Solid-State Lithium Metal Batteries.

Polymer/ceramic-based composite solid electrolytes (CSE) are promising candidates for all-solid-state lithium metal batteries (SLBs), benefiting from the combined mechanical robustness of polymeric electrolytes and the high ionic conductivity of ceramic electrolytes. However, the interfacial instability and poorly understood interphases of CSE hinder their application in high-voltage SLBs. Herein, a simple but effective CSE that stabilizes high-voltage SLBs by forming multiple intermolecular coordination interactions between polyester and ceramic electrolytes is discovered. The multiple coordination between the carbonyl groups in poly(ε-caprolactone) and the fluorosulfonyl groups in anions with Li6.5 La3 Zr1.5 Ta0.5 O12 nanoparticles is directly visualized by cryogenic transmission electron microscopy and further confirmed by theoretical calculation. Importantly, the multiple coordination in CSE not only prevents the continuous decomposition of polymer skeleton by shielding the vulnerable carbonyl sites but also establishes stable inorganic-rich interphases through preferential decomposition of anions. The stable CSE and its inorganic-rich interphases enable Li||Li symmetric cells with an exceptional lifespan of over 4800 h without dendritic shorting at 0.1 mA cm-2 . Moreover, the high-voltage SLB with LiNi0.5 Co0.2 Mn0.3 O2 cathode displays excellent cycling stability over 1100 cycles at a 1C charge/discharge rate. This work reveals the underlying mechanism behind the excellent stability of coordinating composite electrolytes and interfaces in high-voltage SLBs.

Efficacy evaluation of surgery combined with chemotherapy for stage IIIA small cell lung cancer patients: a retrospective analysis.

Background: The efficacy of surgery in combination of chemotherapy for stage IIIA small cell lung cancer (IIIA-SCLC) is controversial. The aim of the present study was to analyze the efficacy of surgery combined with chemotherapy, especially in the setting of neoadjuvant chemotherapy (NAC) followed by surgery for IIIA-SCLC. Methods: Between 2004 and 2015, we reviewed 2,199 chemotherapy-treated stage IIIA (N1/2) SCLC cases in the Surveillance, Epidemiology, and End Results (SEER) database, and 32 NAC + intentional radical resection-treated, centrally-located IIIA-SCLC cases at Shanghai Pulmonary Hospital (SPH). Outcomes were compared between surgically and non-surgically treated patients from the SEER database after propensity score matching (PSM), and comparing lobectomy/bi-lobectomy and pneumonectomy patients from SPH. Prognostic factors were evaluated by Kaplan-Meier method and the Cox proportional hazards regression model. Results: There was significantly higher overall survival (OS) in surgically treated IIIA-SCLC patients (OS, 44.8 vs. 21.2 months, P=0.048), and similar efficacy was observed between sub-lobectomy and lobectomy/bi-lobectomy patients (OS: 55.6 vs. 30.3 months, P=0.167) in SEER database. At SPH, significantly higher OS was associated with T1 stage (before NAC: T1 vs. T2-4, 48.7 vs. 32.2 months, P=0.025; after NAC: T1 vs. T2-4, 42.7 vs. 21.3 months, P=0.048). Female sex [hazard ratio (HR): 0.078, P=0.009], T1 stage (HR: 13.048, P=0.026), and pneumonectomy (HR: 0.095, P=0.009) were independent prognostic factors for IIIA-SCLC patients who received NAC + intentional radical resection. Conclusions: For stage IIIA SCLC patients, complete resection combined with chemotherapy might improve the prognosis than patients without surgery. Post-NAC lobectomy was not found to be superior to sub-lobectomy, while pneumonectomy was considered suitable for central-type IIIA-SCLC patients after NAC treatment.

Bevacizumab-Laden Nanofibers Simulating an Antiangiogenic Niche to Improve the Submuscular Stability of Stem Cell Engineered Cartilage.

Bone marrow stem cells (BMSCs) engineered cartilage (BEC) is prone to endochondral ossification in a submuscular environment due to the process of vascular infiltration, which limits its application in repairing tracheal cartilage defects. Bevacizumab, an antitumor drug with pronounced antiangiogenic activity, is successfully laden into a poly(L-lactide-co-caprolactone) system to prepare bevacizumab-laden nanofiber (BevNF) characterized by 5% and 10% bevacizumab concentrations. The in vitro results reveal that a sustained release of bevacizumab can be realized from BevNF, exhibiting inhibitive cytotoxicity toward human umbilical vein endothelial cells whereas non-cytotoxicity toward BMSCs-induced chondrocytes. A model is also established by encapsulating BEC within BevNF, aiming to realize an antiangiogenic niche under conditions of sustained and localized release of bevacizumab to inhibit the process of vascular invasion, resulting in the eventual stabilization of the cartilaginous phenotype and promotion of the process of cartilage maturation in the submuscular environment. These results also confirm that the chondrogenesis stability of BEC increases with an increase in the bevacizumab concentration, and 10% BevNF is sufficient to protect BEC from vascularization. This demonstrates that the use of BevNF can potentially help develop an effective strategy for regulating the submuscular stability of BEC to repair the defects formed in tracheal cartilage.

Interpersonal Neural Synchronization Predicting Learning Outcomes From Teaching-Learning Interaction: A Meta-Analysis.

In school education, teaching-learning interaction is deemed as a core process in the classroom. The fundamental neural basis underlying teaching-learning interaction is proposed to be essential for tuning learning outcomes. However, the neural basis of this process as well as the relationship between the neural dynamics and the learning outcomes are largely unclear. With non-invasive technologies such as fNIRS (functional near-infrared spectroscopy), hyperscanning techniques have been developed since the last decade and been applied to the field of educational neuroscience for simultaneous multi-brain scanning. Hyperscanning studies suggest that the interpersonal neural synchronization (INS) during teaching-learning interaction might be an ideal neural biomarker for predicting learning outcomes. To systematically evaluate such a relationship, this meta-analysis ran on a random-effects model on 16 studies with 23 independent samples (effect sizes). Further moderator analyses were also performed to examine the potential influences of the style, mode, content, and the assessment method of learning outcomes. The random-effects modeling results confirmed a robust positive correlation between INS and learning outcomes. Subsequent analyses revealed that such relationship was mainly affected by both interaction style and mode. Therefore, the present meta-analysis provided a confirmatory neurocognitive foundation for teaching-learning interaction, as well as its relation to the learning outcomes, consolidated future learning and teaching studies in various disciplines including second language education with a firm methodological reference.

Propensity-matched Comparison of VATS Left Upper Trisegmentectomy and Lobectomy.

BACKGROUND: This study aimed to investigate the oncologic outcomes of video-assisted thoracoscopic (VATS) left upper trisegmentectomy (LTS) vs left upper lobectomy (LUL) for patients presenting with stage I non-small cell lung cancer (NSCLC). METHODS: A retrospective analysis identified 1543 consecutive patients presenting to Shanghai Pulmonary Hospital (Shanghai, China) with NSCLC for VATS LTS or LUL from 2013 to 2017. After propensity-score matching for patient demographics and tumor characteristics, 273 pairs were identified. Disease-free survival (DFS) and overall survival (OS) were estimated by the Kaplan-Meier method and compared using the log-rank test. RESULTS: The median follow-up time was 51.5 months. There were no significant differences in operative duration (2.11 ± 0.64 hours vs 2.49 ± 5.96 hours; P = .30), total blood loss (106.19 ± 170.83 mL vs 97.07 ± 149.34 mL; P = .51), and operative complications (10% vs 8%; P = .37) between the LUL and LTS groups. Patients undergoing LUL had longer postoperative hospital stays (5.55 ± 3.00 days vs 4.87 ± 2.33 days; P = .003), greater tumor margin distance (3.3 ± 1.2 cm vs 3.1 ± 0.9 cm; P < .001), and greater number of lymph nodes harvested (8.0 ± 3.2 vs 6.8 ± 3.3; P < .001) than patients undergoing LTS, but the margin-to-tumor ratio was not statistically different (2.5 ± 1.6 vs 2.3 ± 1.1; P = 0.11). Median DFS (49.5 months vs 54.3 months; P = .77) and OS (49.5 months vs 55.0 months; P = .88) were not significantly different between patients undergoing LTS and those undergoing LUL, and similar outcomes were noted across subgroups of patients stratified by tumor stage, pathologic type, and radiographic manifestations. CONCLUSIONS: VATS LTS and LUL had comparable oncologic outcomes for stage I NSCLC, regardless of tumor pathologic types and radiologic findings, as long as negative margins were confirmed.

Collaborative relationships in translational medical research among Chinese clinicians: an internet-based cross-sectional survey.

BACKGROUND: This study aimed to explore the collaborative relationship in translational medical research from the perspective of clinicians in China. The findings are expected to help practitioners optimize and experience the greatest advantages of collaboration. METHODS: We conducted a national internet-based survey from July 29 to October 12, 2020. Of the 806 responses, 804 were completed with valid responses (valid response rate = 99.8%). The collected data were presented as descriptive statistics and analyzed using nonparametric tests (including the Wilcoxon rank test and Kruskal-Wallis H test) and stepwise logistic regression. RESULTS: Of the 804 participants, 733 were either willing or very willing to collaborate in translational medical research. Clinicians' willingness was influenced by their current research type, role in current translational medical research, burdens of their present research, preferred partners for collaboration at the institutional or individual level, and preferences for independent or dependent relationships. CONCLUSIONS: Clinicians should evaluate their time, role, burdens, personal preferences for research relationships, and appropriate partners based on their current translational medical research and its goals, before deciding to collaborate.

In Situ Coating of Li7P3S11 Electrolyte on CuCo2S4/Graphene Nanocomposite as a High-Performance Cathode for All-Solid-State Lithium Batteries.

A cathode material, CuCo2S4/graphene@10%Li7P3S11, is reported for all-solid-state lithium batteries with high performance. The electrical conductivity of CuCo2S4 is improved by compounding with graphene. Meanwhile, Li7P3S11 electrolyte is coated on the surface of CuCo2S4/graphene nanosheets to build an intimate contact interface between the solid electrolyte and the electrode effectively, facilitating lithium-ion conduction. Benefitting from the balanced and efficient electronic and ionic conductions, all-solid-state lithium batteries using CuCo2S4/graphene@10%Li7P3S11 composite as cathode materials demonstrate superior cycling stability and rate capabilities, exhibiting an initial discharge specific capacity of 1102.25 mAh g-1 at 50 mA g-1 and reversible capacity of 556.41 mAh g-1 at a high current density of 500 mA g-1 after 100 cycles. These results demonstrate that the CuCo2S4/graphene@10%Li7P3S11 nanocomposite is a promising active material for all-solid-state lithium batteries with superior performances.

Co3S4@Li7P3S11 Hexagonal Platelets as Cathodes with Superior Interfacial Contact for All-Solid-State Lithium Batteries.

Poor solid-solid contact between an electrode and solid electrolyte is a great challenge for all-solid-state lithium batteries (ASSLBs) which results in limited ion transport and eventually leads to rapid capacity fading. Two-dimensional (2D) materials have incomparable advantage in the construction of the desired interface because of their flat surface and large specific surface area. In order to realize intimate interfacial contact and superior ion transport, monodisperse 2D Co3S4 hexagonal platelets as cathodes for all ASSLBs are synthesized through a series of topological reactions followed with in situ coating of tiny Li7P3S11 using a liquid-phase method. The unique 2D hexagonal platelets are favorable for in situ solid electrolyte coating. Moreover, the well-designed interfacial structure can make the electrode materials contact with solid electrolytes more closely, contributing to a remarkable improvement on electrochemical performance. ASSLBs employing the Co3S4@Li7P3S11 composite platelets as a cathode deliver a large reversible capacity of 685.9 mA h g-1 at 0.5 A g-1 for 50 cycles. Even at a high current density of 1 A g-1, the Co3S4@Li7P3S11 composite cathode still exhibits a high capacity of 457.3 mA h g-1 after 100 cycles. This work provides a simple strategy to design the composite electrode with intimate contact and superior ion transport via morphology controlling.

The complete chloroplast genome of Musa acuminata var. chinensis.

Musa acuminata var. chinensis is one of the most important wild banana species native to China which has huge potential breeding value by its cold tolerance and disease resistance. In this study, we first reported the complete chloroplast genome of M. acuminata var. chinensis and explore its phylogenetic position using a maximum likelihood phylogenetic tree. The chloroplast genome of M. acuminata var. chinensis is 170,402 bp in length and the overall GC content of the whole genome is 36.8%. It consisting of a pair of inverted repeat (IR, 35,320 bp) regions, a large single-copy (LSC, 88,870 bp) and a small single-copy (SSC, 10,900 bp). The chloroplast genome contained 112 genes, including 79 protein-coding genes, 29 tRNA genes, and 4 rRNA ribosomal genes. The most genes occur as a single copy, while 23 gene species occur in double copies. Phylogenetic analysis of 7 selected chloroplast genomes revealed that M. acuminata var. chinensis was closely related to M. acuminata ssp. malaccensis. The complete chloroplast genome of M. acuminata var. chinensis will greatly enhance precious gene resources for banana breeding programs in the future.

The complete chloroplast genome of Musa beccarii.

Musa becccarii N.W. Simmonds is one of the most important wild banana species native to Borneo. The chromosome number, 2n = 18, is new to the genus Musa. Wild populations of M. beccarii have been reduced enormously due to massive land clearing for oil palm plantations. In this study, we report the complete chloroplast genome of Musa beccarii by next-generation sequencing (NGS). The total length of the complete chloroplast genome was 168,457 bp, and the overall GC content of the whole genome is 36.8%. The cp genome of Musa beccarii contained a pair of inverted repeat regions of 34,819 bp, which were separated by the large single copy of 88,166bp and the small single copy of 11,059 bp. It encoded 114 genes, including 79 protein-coding genes, 31 tRNA genes, and 4 rRNA ribosomal genes. The most genes occur as a single copy, while 21 gene species occur in double copies. The phylogenetic analysis demonstrateds Musa becccarii formed a single branch among genus Musa. This complete chloroplast genome will provide important information for conservation and identification of species of Musa spp.

Si/a-C Nanocomposites with a Multiple Buffer Structure via One-Step Magnetron Sputtering for Ultrahigh-Stability Lithium-Ion Battery Anodes.

Large volume expansion and serious pulverization of silicon are two major challenges for Si-based anode batteries. Herein, a high-mass-load (3.0 g cm-3) silicon-doped amorphous carbon (Si/a-C) nanocomposite with a hierarchical buffer structure is prepared by one-step magnetron sputtering. The uniform mixing of silicon and carbon is realized on the several-nanometer scale by cosputter deposition of silicon and carbon. The boundary of the primary particles, made up of nanocarbon and nanosilicon, and the boundary of the secondary particles aggregated by the primary particles can provide accommodation space for the volume expansion of silicon and effectively buffer the volume expansion of silicon. Meanwhile, the continuous and uniformly distributed amorphous carbon enhances the conductivity of the Si/a-C nanocomposites. Typically, the 20% Si/a-C cell shows a superior initial discharge capacity of 845.3 mAh g-1 and achieves excellent cycle performance of up to 1000 cycles (609.4 mAh g-1) at the current density of 1 A g-1. Furthermore, the 20% Si/a-C cell exhibits a high capacity of 602.8 mAh g-1 with the stable discharge/charge rate performance in several extreme conditions (-40-70 °C). In view of the validity and mass productivity of the magnetron sputtering, a potential route for the industrial preparation of the Si/a-C anode nanocomposites is therefore highlighted by this study.

Microbial Community Diversity Within Sediments from Two Geographically Separated Hadal Trenches.

Hadal ocean sediments, found at sites deeper than 6,000 m water depth, are thought to contain microbial communities distinct from those at shallower depths due to high hydrostatic pressures and higher abundances of organic matter. These communities may also differ from one other as a result of geographical isolation. Here we compare microbial community composition in surficial sediments of two hadal environments-the Mariana and Kermadec trenches-to evaluate microbial biogeography at hadal depths. Sediment microbial consortia were distinct between trenches, with higher relative sequence abundances of taxa previously correlated with organic matter degradation present in the Kermadec Trench. In contrast, the Mariana Trench, and deeper sediments in both trenches, were enriched in taxa predicted to break down recalcitrant material and contained other uncharacterized lineages. At the 97% similarity level, sequence-abundant taxa were not trench-specific and were related to those found in other hadal and abyssal habitats, indicating potential connectivity between geographically isolated sediments. Despite the diversity of microorganisms identified using culture-independent techniques, most isolates obtained under in situ pressures were related to previously identified piezophiles. Members related to these same taxa also became dominant community members when native sediments were incubated under static, long-term, unamended high-pressure conditions. Our results support the hypothesis that there is connectivity between sediment microbial populations inhabiting the Mariana and Kermadec trenches while showing that both whole communities and specific microbial lineages vary between trench of collection and sediment horizon depth. This in situ biodiversity is largely missed when incubating samples within pressure vessels and highlights the need for revised protocols for high-pressure incubations.

Nanoscaled Na3PS4 Solid Electrolyte for All-Solid-State FeS2/Na Batteries with Ultrahigh Initial Coulombic Efficiency of 95% and Excellent Cyclic Performances.

Nanosized Na3PS4 solid electrolyte with an ionic conductivity of 8.44 × 10-5 S cm-1 at room temperature is synthesized by a liquid-phase reaction. The resultant all-solid-state FeS2/Na3PS4/Na batteries show an extraordinary high initial Coulombic efficiency of 95% and demonstrate high energy density of 611 Wh kg-1 at current density of 20 mA g-1 at room temperature. The outstanding performances of the battery can be ascribed to good interface compatibility and intimate solid-solid contact at FeS2 electrode/nanosized Na3PS4 solid electrolytes interface. Meanwhile, excellent cycling stability is achieved for the battery after cycling at 60 mA g-1 for 100 cycles, showing a high capacity of 287 mAh g-1 with the capacity retention of 80%.

Highly Crystalline Layered VS2 Nanosheets for All-Solid-State Lithium Batteries with Enhanced Electrochemical Performances.

All-solid-state lithium batteries employing inorganic solid electrolytes have been regarded as an ultimate solution to safety issues because of their features of no leakage as well as incombustibility and they are expected to achieve higher energy densities owing to their simplified structure. Two-dimensional transition-metal dichalcogenides exhibit a great potential in energy storage devices because of their unique physical and chemical characteristics. In this work, 50 nm thick highly crystalline layered VS2 (hc-VS2) nanosheets are prepared by a solvothermal method, and their electrochemical performances are evaluated in Li/75% Li2S-24% P2S5-1% P2O5/Li10GeP2S12/hc-VS2 all-solid-state lithium batteries. At 50 mA g-1, hc-VS2 nanosheets show a high reversible capacity of 532.2 mAh g-1 after 30 cycles. Moreover, stable discharge capacities are maintained at 436.8 and 270.4 mAh g-1 at 100 and 500 mA g-1 after 100 cycles, respectively. The superior rate capability and cycling stability are ascribed to the better electronic conductivity and well-developed layered structure. In addition, the electrochemical reaction kinetics and capacity contributions were analyzed via cyclic voltammetry measurements at different scan rates.

Core-Shell Fe1- xS@Na2.9PS3.95Se0.05 Nanorods for Room Temperature All-Solid-State Sodium Batteries with High Energy Density.

High ionic conductivity electrolyte and intimate interfacial contact are crucial factors to realize high-performance all-solid-state sodium batteries. Na2.9PS3.95Se0.05 electrolyte with reduced particle size of 500 nm is first synthesized by a simple liquid-phase method and exhibits a high ionic conductivity of 1.21 × 10-4 S cm-1, which is comparable with that synthesized with a solid-state reaction. Meanwhile, a general interfacial architecture, that is, Na2.9PS3.95Se0.05 electrolyte uniformly anchored on Fe1- xS nanorods, is designed and successfully prepared by an in situ liquid-phase coating approach, forming core-shell structured Fe1- xS@Na2.9PS3.95Se0.05 nanorods and thus realizing an intimate contact interface. The Fe1- xS@Na2.9PS3.95Se0.05/Na2.9PS3.95Se0.05/Na all-solid-state sodium battery demonstrates high specific capacity and excellent rate capability at room temperature, showing reversible discharge capacities of 899.2, 795.5, 655.1, 437.9, and 300.4 mAh g-1 at current densities of 20, 50, 100, 150, and 200 mA g-1, respectively. The obtained all-solid-state sodium batteries show very high energy and power densities up to 910.6 Wh kg-1 and 201.6 W kg-1 based on the mass of Fe1- xS at current densities of 20 and 200 mA g-1, respectively. Moreover, the reaction mechanism of Fe1- xS is confirmed by means of ex situ X-ray diffraction techniques, showing that partially reversible reaction occurs in the Fe1- xS electrode after the second cycle, which gives the obtained all-solid-state sodium battery an exceptional cycling stability, exhibiting a high capacity of 494.3 mAh g-1 after cycling at 100 mA g-1 for 100 cycles. This contribution provides a strategy for designing high-performance room temperature all-solid-state sodium battery.

Interface Re-Engineering of Li10GeP2S12 Electrolyte and Lithium anode for All-Solid-State Lithium Batteries with Ultralong Cycle Life.

An ingenious interface re-engineering strategy was applied to in situ prepare a manipulated LiH2PO4 protective layer on the surface of Li anode for circumventing the intrinsic chemical stability issues of Li10GeP2S12 (LGPS) to Li metal, specifically the migration of mixed ionic-electronic reactants to the inner of LGPS, and the kinetically sluggish reactions in the interface. As consequence, the stability of LGPS with Li metal increased substantially and the cycling of symmetric Li/Li cell showed that the polarization voltage could keep relative stable for over 950 h at 0.1 mA cm-2 within ±0.05 V. The optimized ASSLiB of LiCoO2 (LCO)/LGPS/Li with interface-engineered structure was able to deliver long cycle life and high capacity, i.e., a reversible discharge capacity of 131.1 mAh g-1 at the initial cycle and 113.7 mAh g-1 at the 500th cycle under 0.1 C with a retention of 86.7%. In addition, the factors effected on the interphases formation of the LGPS/Li interface were analyzed, and the mechanism of the stability between LGPS and Li anode with protective layer was further investigated. Moreover, the probable causes of battery degradation were also explored. Above all, this work would give an alternative strategy for the modification of Li anode in high energy density solid-state lithium metal batteries.

Clinicopathological features of Chinese lung cancer patients with epidermal growth factor receptor mutation.

BACKGROUND: Epidermal growth factor receptor (EGFR) gene was the major causative gene of lung cancer and also the specific treatment target. It is necessary to analyze the genotype and phenotype characters of patients. METHODS: We investigated 1,034 lung cancer patients in this study. The collected clinicopathological parameters included gender, age at diagnosis, smoking status, pathological TNM stage, tumor morphology and location, visceral pleural invasion as well as histological type. RESULTS: Almost 50% participants had EGFR mutations. L858R in exon 21 was the most common type. Concomitant mutation, 19 del and L858R, were detected in 20 patients. Compared to patients with exon 19 del or L858R mutations solely, they were inclined to have small size adenocarcinomas which occurred in bilateral and invaded the visceral pleura. The tyrosine kinases inhibitors (TKIs)-resistant mutation, insertions in exon 20, was detected in 11 patients. CONCLUSIONS: The summarized clinicopathological features will help clinicians to implement the feasible treatment plan.

Proton enhanced dynamic battery chemistry for aprotic lithium-oxygen batteries.

Water contamination is generally considered to be detrimental to the performance of aprotic lithium-air batteries, whereas this view is challenged by recent contrasting observations. This has provoked a range of discussions on the role of water and its impact on batteries. In this work, a distinct battery chemistry that prevails in water-contaminated aprotic lithium-oxygen batteries is revealed. Both lithium ions and protons are found to be involved in the oxygen reduction and evolution reactions, and lithium hydroperoxide and lithium hydroxide are identified as predominant discharge products. The crystallographic and spectroscopic characteristics of lithium hydroperoxide monohydrate are scrutinized both experimentally and theoretically. Intriguingly, the reaction of lithium hydroperoxide with triiodide exhibits a faster kinetics, which enables a considerably lower overpotential during the charging process. The battery chemistry unveiled in this mechanistic study could provide important insights into the understanding of nominally aprotic lithium-oxygen batteries and help to tackle the critical issues confronted.

High-Energy All-Solid-State Lithium Batteries with Ultralong Cycle Life.

High energy and power densities are the greatest challenge for all-solid-state lithium batteries due to the poor interfacial compatibility between electrodes and electrolytes as well as low lithium ion transfer kinetics in solid materials. Intimate contact at the cathode-solid electrolyte interface and high ionic conductivity of solid electrolyte are crucial to realizing high-performance all-solid-state lithium batteries. Here, we report a general interfacial architecture, i.e., Li7P3S11 electrolyte particles anchored on cobalt sulfide nanosheets, by an in situ liquid-phase approach. The anchored Li7P3S11 electrolyte particle size is around 10 nm, which is the smallest sulfide electrolyte particles reported to date, leading to an increased contact area and intimate contact interface between electrolyte and active materials. The neat Li7P3S11 electrolyte synthesized by the same liquid-phase approach exhibits a very high ionic conductivity of 1.5 × 10-3 S cm-1 with a particle size of 0.4-1.0 µm. All-solid-state lithium batteries employing cobalt sulfide-Li7P3S11 nanocomposites in combination with the neat Li7P3S11 electrolyte and Super P as the cathode and lithium metal as the anode exhibit excellent rate capability and cycling stability, showing reversible discharge capacity of 421 mAh g-1 at 1.27 mA cm-2 after 1000 cycles. Moreover, the obtained all-solid-state lithium batteries possesses very high energy and power densities, exhibiting 360 Wh kg-1 and 3823 W kg-1 at current densities of 0.13 and 12.73 mA cm-2, respectively. This contribution demonstrates a new interfacial design for all-solid-state battery with high performance.