RESUMEN
HLA-B*15:659 differs from HLA-B*15:02:01:01 by one nucleotide in exon 2.
Asunto(s)
Alelos , Pueblo Asiatico , Secuencia de Bases , Exones , Prueba de Histocompatibilidad , Análisis de Secuencia de ADN , Humanos , Pueblo Asiatico/genética , Análisis de Secuencia de ADN/métodos , Antígeno HLA-B15/genética , Antígeno HLA-B15/inmunología , Alineación de Secuencia , Codón , Donantes de Tejidos , Pueblos del Este de AsiaRESUMEN
HLA-DPA1*02:117 differs from HLA-DPA1*02:02:02:01 by one nucleotide in exon 2.
Asunto(s)
Cadenas alfa de HLA-DP , Nucleótidos , Humanos , Alelos , Cadenas alfa de HLA-DP/genética , China , Análisis de Secuencia de ADNRESUMEN
HLA-DPB1*05:01:21 differs from HLA-DPB1*05:01:01:01 by one nucleotide in exon 3.
Asunto(s)
Cadenas beta de HLA-DP , Nucleótidos , Humanos , Alelos , Secuencia de Bases , ChinaRESUMEN
HLA-C*03:651 differs from HLA-C*03:03:01:01 by one nucleotide in exon 4.
Asunto(s)
Antígenos HLA-C , Nucleótidos , Humanos , Antígenos HLA-C/genética , Alelos , Secuencia de Bases , China , Análisis de Secuencia de ADNRESUMEN
HLA-B*40:555 differs from HLA-B*40:01:02:01 by one nucleotide in exon 3.
Asunto(s)
Antígenos HLA-B , Nucleótidos , Humanos , Alelos , Análisis de Secuencia de ADN , Antígenos HLA-B/genética , ChinaRESUMEN
HLA-C*17:69 differs from HLA-C*17:01:01:02 by one nucleotide in exon 4.
Asunto(s)
Antígenos HLA-C , Nucleótidos , Humanos , Antígenos HLA-C/genética , Alelos , Secuencia de Bases , China , Análisis de Secuencia de ADNRESUMEN
The objective of this study was to investigate the relationship between alanine aminotransferase and related biochemical parameters and potential risk factors in women with premature ovarian insufficiency (POI). This is a retrospective cohort study with 126 POI patients (including subclinical POI, n= 27) and 130 healthy controls who visited our clinic between April 2021 to November 2022. Associations were investigated by multiple linear regression, Person correlation analysis, the Kruskal-Wallis test, Mann-Whitney U test, and the independent t-test. When compared to controls, analysis of POI patients showed that body mass index (BMI), uric acid (UA) and urea, alanine aminotransferase (ALT), aspartate aminotransferase (AST), monocyte/lymphocyte ratio, monocyte count (MONO), neutrophil count (NEUT), follicle-stimulating hormone (FSH), luteinizing hormone, and neutrophil/lymphocyte ratio (NLR) were significantly higher, while estradiol (E2), the lymphocyte count and the AST/ALT ratio were lower (P < 0.05). According to linear correlation, it was clear that BMI, FSH, white blood cell count (WBC), NEUT, MONO, UA, AST, and NLR were positively associated with ALT (r = 0.215, 0.388, 0.195, 0.187, 0.184, 0.605, 0.819, and 0.189, respectively, all P < 0.05) while E2 was negatively associated with ALT (r = -0.278, P < 0.05). In addition, multiple linear regression revealed a significant, independent, and positive correlation between AST, FSH, and ALT (B =1.403 and 0.069, respectively, P < 0.05). Analysis revealed that the levels of ALT were significantly higher in POI patients. In addition, BMI, FSH, UA, AST, MONO, NLR, NEUT, and WBC were positively associated with ALT in POI patients. E2 was negatively associated with ALT. Multiple linear regression revealed an independent and positive correlation between AST, FSH, and ALT. In addition, there was also a risk of liver function damage in women with POI and subclinical POI. If patients were diagnosed with POI, early examination and corresponding intervention will be required to effectively prevent the further development of liver disease.
