Suicide Probability Among Patients With Schizophrenia and Bipolar Disorder.

PURPOSE: To evaluate the possibility of suicide and related factors among individuals with schizophrenia and bipolar disorder (BD). METHOD: Data were collected for 270 individuals registered in a community mental health center using the Suicide Probability Scale (SPS). Subsequently, t test and multiple linear regression analyses were conducted on independent samples. RESULTS: There was no statistically significant difference found between mean SPS scores of participants with schizophrenia and BD. However, hostility subscale mean scores of participants with schizophrenia were higher than those of participants with BD, and the difference was statistically significant. Sex, family history of mental illness, need for help with medication, suicidal ideation in the past 10 days, and number of suicide attempts were important predictors of suicide probability. CONCLUSION: Individuals with schizophrenia and BD and in remission should be evaluated periodically for the possibility of suicide. [Journal of Psychosocial Nursing and Mental Health Services, xx(xx), xx-xx.].

Phenolic Content Analysis of Two Species Belonging to the Lamiaceae Family: Antioxidant, Anticholinergic, and Antibacterial Activities.

The Lamiaceae family are utilized as ornamental, medicinal, and food supplements throughout the world. The current study focuses on a comparative analysis of the phenolic compositions and bioactivities (including antioxidant, anticholinergic, and antibacterial activities) of ethanolic extracts derived from the aerial parts of the two species (Lavandula stoechas L. and Thymus sipyleus Boiss). The presence of phenolic compounds and phytochemicals in the plant extracts was identified using the LC-MS/MS technique. The LC-MS/MS analysis revealed that vanillic acid (125,596.66 µg/L) was the most abundant phytochemical in L. stoechas. Kaempferol (8550.52 µg/L) was the most abundant substance in Thymus sipyleus. The assessment of the antioxidant efficacy of the species extracts was conducted using the DPPH (2.2-diphenyl-1-picryl-hydrazyl-hydrate), ABTS (2.2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid)), Fe3+-Fe2+ reducing, and CUPRAC (Cu2+-Cu+ reducing) assays. The anticholinergic activity of the samples was determined using the acetylcholinesterase (AChE) inhibition assay. The results of antioxidant activity were higher in the T. sipyleus than in the L. stoechas ethanol extracts. The extracts of L. stoechas exhibited radical scavenging activity ranging from 15 to 18%, while T. sipyleus had activity effects ranging from 34% to 38%. The AChE inhibition potential for L. stoechas and T. sipyleus extracts as IC50 values were 0.221 ± 0.01 mg/mL and 0.067 ± 0.02 mg/mL, respectively. The antibacterial effects of the ethanolic extracts of these species against pathogenic bacteria isolates were determined using the MIC (minimal inhibitory concentration) method. These findings indicated that the extracts from L. stoechas and T. sipyleus possess the potential to be natural antioxidants in the realm of food preservation. Additionally, their antioxidant, anticholinergic, and antimicrobial properties suggest potential therapeutic utility in the management of certain diseases.

Nursing students' metaphorical perceptions of sexuality in older people: An example of metaphor analysis.

PURPOSE: This study aims to describe the metaphorical perceptions of nursing students towards sexuality in older people through metaphor. BACKGROUND: Age-related changes and health problems can adversely affect sexual functions. Sexuality is a basic physiological need that continues throughout life and it is important to eliminate the problems related to sexual life that occur in old age. Determining the knowledge and attitudes of nursing students, who will be health professionals of the future, towards sexuality in older people can make a significant contribution to providing holistic health care to older individuals. Therefore, it is important to determine the knowledge and attitudes of nursing students about the sexuality of older people to improve their professional competence. DESIGN: This study was conducted with metaphor analysis technique based on phenomenological method. METHOD: This study was conducted in a total of 222 nursing students. The study data were collected between January and February 2022 with a questionnaire form prepared by the researchers. In the first part of the questionnaire, questions about socio-demographic characteristics were included, and in the second part, the sentence "sexuality in older people is like., because." was included to determine the metaphors developed by the students about sexuality in older people. These handwritten writings of the students were used as the main data source in this study. Content analysis was used to evaluate the metaphors. RESULTS: In this study, students produced a total of 222 valid metaphors related to the concept of sexuality in older people. The metaphors revealing the students' perceptions of the concept of sexuality in older people were grouped under 5 categories; "Category related to slowing down and regression", "Category related to need or normal", "Category related to not possible", "Category related to the feeling of love, compassion and friendship" and "Unnecessary, unimportant or should not be category". In the study, it was determined that the category in which the most metaphors were generated was "related to slowing down and regression". CONCLUSION: In the study, nursing students provided metaphors containing both positive and negative concepts related to sexuality in older people. However, most the metaphors generated contain negative concepts. To support nursing students' positive attitudes towards sexuality in older people, to change their negative attitudes, and to increase their knowledge and awareness, it is proposed to incorporate courses on sexuality in older people into the nursing curriculum and to include sexuality in older people in courses on sexuality.

A General Review of Methodologies Used in the Determination of Cholesterol (C27H46O) Levels in Foods.

Cholesterol (C27H46O) is a lipid-derived substance found in lipoproteins and cell membranes. It is also one of the main sources for the production of bile acids, vitamin D, and steroid hormones. Today, foods are evaluated by consumers not only according to their taste and nutritional content but also according to their effects on consumer health. For example, many consumers choose foods according to their cholesterol level. The cholesterol in the food can directly affect the blood cholesterol level when consumed, which can lead to cardiovascular diseases. High levels of cholesterol can lead to diet-related human diseases such as cardiac arrest, paralysis, type II diabetes, and cerebral hemorrhage. In societies with high living standards, interest in and consumption of foods that lower or have low cholesterol levels have increased recently. Accordingly, efforts to increase the variety of foods with reduced cholesterol levels are on the rise. This has indirectly led to the accurate measurement of cholesterol levels in blood and food being of great importance. Classical chemical, enzymatic, colorimetric, polarographic, chromatographic, and spectrophotometric methods; enzymatic, nonenzymatic, and electrochemical sensors; and biosensors are used for the determination of cholesterol in foods. The purpose of this review is to reveal and explore current and future trends in cholesterol detection methods in foods. This review will summarize the most appropriate and standard methods for measuring cholesterol in biological components and foods.

Can circulating oxidative stress-related biomarkers be used as an early prognostic marker for COVID-19?

Background: Oxidative stress plays an important role in the pathogenesis of many diseases. This study aimed to investigate the relationship between nuclear factor kappa B (NF-κB) and oxidative stress and the severity of the disease in new COVID-19 patients, and, to compare the levels of NF-κB, oxidized LDL (oxLDL), and lectin-like oxidized-LDL receptor-1 (LOX-1) with oxygen saturation, which is an indicator of the severity parameters of the disease in COVID-19 patients. Methods: In this prospective study, 100 COVID-19 patients and 100 healthy subjects were selected. Results: LOX-1, NF-κB, and oxLDL were found to be higher in COVID-19 patients compared to the healthy subjects (p < 0.001 for all). According to the results of correlation analysis, it was found that there was no significant relationship between oxygen saturation and LOX-1, NF-κB and oxLDL parameters. There was significant relationship between oxLDL with LOX-1 and NF-κB in patients with COVID-19 disease. ROC analysis results of the highest discrimination power were oxLDL (AUC: 0.955, CI: 0.904-1.000; sensitivity: 77%, and specificity: 100%, for cutoff: 127.944 ng/l) indicating COVID-19. Conclusion: Oxidative stress plays an essential role in COVID-19. NF-κB, oxLDL, and LOX-1 seem to represent good markers in COVID-19. Our study also showed that oxLDL has the highest power in distinguishing patients with COVID-19 from the healthy subjects.

Spiritual Well-Being and Psychological Well-Being Among Hemodialysis Patients in Turkey: A Descriptive and Correlational Study.

This study aimed to determine the psychological and spiritual well-being of hemodialysis patients in Turkey. This descriptive and correlational study included 86 hemodialysis patients. Data were collected using the Spiritual Well-Being Scale and Psychological Well-Being Scale. There was a positive correlation between spiritual and psychological well-being (r = 0.315, p = 0.003). Psychological well-being and age explained 39% of total variance (F = 7.593, p = 0.001). In conclusion, there should be provided individualized spiritual care and counseling to improve the psychological well-being of hemodialysis patients.

Nutritional Supplementation of Yogurt with Jerusalem Artichoke Tubers: Organic Acid Profiles and Quality Parameters.

Jerusalem artichoke (Helianthus tuberosus L.), also called wild sunflower, belongs to the Asteraceae family and is cultivated widely across the temperate zone for its nutritious tuber, which is used as a root vegetable. In this study, the Jerusalem artichoke (JA) was used as a supplementary additive for producing a functional yogurt, with enhanced health benefits and improving the microbiological, rheological, and sensorial quality characteristics of the product. The effects of the three different concentrations (1%, 2%, and 3%, w/w) of JA on the physicochemical properties, bacterial counts, sensorial properties, and organic acid profiles of yogurts were determined after 1, 7, 14, and 21 days of storage at ±4 °C. The results obtained revealed that with the addition of different concentrations of JA the overall parameters were statistically significant (p < 0.01 and p < 0.05) except for apparent viscosity, Streptococcus thermophilus, yeast and mold count, pyruvic ratios, and scores of flavor. Similarly, some parameters (fat ratio, yeast and mold count, concentrations of propionic, acetic, pyruvic, orotic, and lactic acids, and scores of appearance, consistency, and odor) changed depending on the storage time, while some did not show any changes regarding storage time. There was a relationship found between the concentration of JA and organic acid ratio (except for pyruvic acid) concentration in the yogurt samples. In conclusion, the research revealed the effect of JA in yogurt production as a thickener, flavor enhancer, prebiotic agent, and source of organic acids and bioactive compounds. The results indicate that JA has a good potential for enhancing the nutritional and physicochemical properties of the studied yogurt.

Determination of Health Anxiety and Resilience Levels in Patients with Fibromyalgia Syndrome and Rheumatoid Arthritis During SARS-CoV-2 Pandemic: A Case-Control Study.

Background: Fibromyalgia Syndrome and Rheumatoid Arthritis are chronic diseases associated with pain. These diseases reduce the patient's quality of life and cause psychological problems. The study aimed to determine health anxiety and resilience levels in patients with fibromyalgia syndrome and rheumatoid arthritis during the severe acute respiratory syndrome coronavirus 2 pandemic. Methods: This case-control study conducted in Central Anatolia Region, Turkey, included 180 participants (60 patients with fibromyalgia syndrome, 60 patients with rheumatoid arthritis, and 60 healthy subjects). Data were collected using the Brief Resilience Scale and Health Anxiety Scale. Pain intensity was assessed using the Visual Analog Scale. Results: Resilience was significantly higher in healthy controls than in the fibromyalgia syndrome and rheumatoid arthritis groups (P < .001). Resilience was also higher in the rheumatoid arthritis group than fibromyalgia syndrome (P < .001) group. Hypersensitivity to somatic symptoms and anxiety, negative results of diseases, and total scores of Health Anxiety Scale were significantly higher in the fibromyalgia syndrome and rheumatoid arthritis groups than healthy controls (P < .001). Also, Health Anxiety Scale scores in the fibromyalgia syndrome group were higher than the rheumatoid arthritis group (P < .001). There was a very strong and negative correlation between the participants' resilience and health anxiety levels (r = -0.818, P < .001). The most important predictors of resilience were hypersensitivity to somatic symptoms and anxiety (r = -0.335, P < .001), the group (r = 0.302, P = .003), the pain intensity (r = -0.169, P = .043), and the negative consequences of the disease (r = -.149, P = .038). The hypersensitivity to somatic symptoms and anxiety, the Visual Analog Scale, and the negative consequences of the disease were negatively correlated with resilience. But there was a positive correlation between fibromyalgia syndrome and rheumatoid arthritis groups and resilience. Conclusions: Patients with fibromyalgia syndrome and rheumatoid arthritis have low resilience and high health anxiety. The interventions should be planned to increase resilience and decrease the health anxiety of patients with fibromyalgia syndrome and rheumatoid arthritis.

Evaluation of Photon Interaction Parameters of Some Antioxidants for Food Irradiation Applications.

This study aimed to investigate the interaction parameters of antioxidant molecules in some spices and vegetables with gamma radiation. At first, mass attenuation coefficients (MACs, cm2/g) of gingerol, rosmarinic acid, quercetin, curcumin, eugenol, piperine, allicin, and capsaicin molecules were determined at the photon energies (13-1332 keV) emitted from the radioactive isotopes Am-241, Ba-133, Co-60, and Cs-137 with the help of the EpiXS and WinXCOM programs. The smallest and largest MAC values were found as 1.20 and 8.48 cm2/g at 13 keV and 0.059 and 0.058 cm2/g at 1332 keV for eugenol and allicin, respectively. It was observed that both results support each other. Using the MAC values, the effective atomic number and electron density (Zeff and Neff) values of the molecules were derived. The Zeff values for gingerol and allicin were obtained in the range of 5.79-3.40 and 13.85-4.53, respectively. The variation of the buildup factors of antioxidants in the range of 0.015-15 MeV depending on the chemical composition and penetration depth were also examined. It was noticed that the photon accumulation was the lowest in allicin and the highest in gingerol and eugenol. The results obtained from this study will make an essential contribution to dose calculations in food irradiation studies.

Phenolic Profile and Antioxidant, Anticholinergic, and Antibacterial Properties of Corn Tassel.

Corn tassel (CT) is a waste part of the corn plant. It is a good co-product and rich in terms of bioactive compounds and phytochemicals. This research tried to show the phenolic profile, antioxidants, anticholinergic activities, and antibacterial properties of CT ethanol extract. The phenolic content analysis of the CT was determined quantitatively by LC-MS/MS, and the antioxidant capacity was measured using ABTS, DPPH, Cu2+-Cu+, and Fe3+-Fe2+ reducing methods. The anticholinergic measurements of CT were detected by inhibition of acetylcholinesterase (AChE). The antibacterial activity was determined by MIC and disc diffusion methods. Many phenolic compounds such as vanillic acid, caffeic acid, fumaric acid, acetohydroxamic acid, butein, myricetin, resveratrol, catechin hydrate, and 4-hydroxybenzoic acid were detected in ethanol extract of CT. The obtained plant ethanol extract had a 7.04% DPPH value, while it showed ABTS activity at 9.45%. Moreover, it had a 0.10 mg/mL inhibition effect on the AChE in terms of IC50 values. The ethanol extract of the CT had an antibacterial property on the investigated bacteria at different ratios. In conclusion, this research aims to consider CT as a source of phenolic compounds and to reveal its bioactive properties and its effects on the treatment of some diseases.

The effect of medication adherence on psychosocial adjustment to body weight, image, and self-esteem in patients with schizophrenia.

PURPOSE: The present study aimed to evaluate the effect of medication adherence on psychosocial adjustment to body weight, image, and self-esteem in patients with schizophrenia. DESIGN AND METHODS: This cross-sectional and correlational study consisted of 154 patients with schizophrenia registered in a Community Mental Health Center. FINDINGS: The patients had moderate psychosocial adjustment to body weight, image, and self-esteem, and 56.5% had poor medication adherence. There was a significant positive correlation between participants' medication adherence and psychosocial adjustment to body weight, image, and self-esteem. PRACTICE IMPLICATIONS: Psychiatric nurses should support patients regarding medication adherence, and psychosocial adjustment to body weight, image, and self-esteem.

The Relationship between Alexithymia, Psychological Well-Being and Religious Coping in Fibromyalgia Patients in Turkey.

This study aimed to investigate the relationship between alexithymia, psychological well-being, and religious coping in fibromyalgia patients. This study was planned as a descriptive and cross-sectional research design. The sample consisted of 175 fibromyalgia patients. Data were collected using the Toronto Alexithymia Scale-20, the Psychological Well-being Scale, and the Religious Coping Scale. Data were analyzed by Pearson's correlation test and Multiple Linear Regression analysis. A negative correlation was found between alexithymia and negative religious coping (r = - 0.377, p = 0.000). A positive correlation was found between psychological well-being and negative religious coping (r = 0.364, p = 0.000). The alexithymia was predicted by psychological well-being level (ß = - 0.629), positive (ß = 0.170) and negative (ß = - 0.216) religious coping levels (p < 0.05). Negative and positive religious coping strategies can affect psychological well-being and expressive thinking in patients with FMS.

The Effect of Mindfulness-Based Psychosocial Skills Training on Functioning and Insight Level in Patients with Schizophrenia.

This study aims to determine the effect of mindfulness-based psychosocial skills training (MBPST) on the functional recovery and insight level in patients with schizophrenia. In this study, 40 patients with schizophrenia registered in the Aksaray Community Mental Health Centre were divided into two groups: the intervention group (n = 20) and the non-intervention group (n = 20). The Functional Recovery Scale in Schizophrenia (FRSS) and the Beck Cognitive Insight Scale (BCIS) were measured at preintervention and postintervention. The posttest mean scores of FRSS and BCIS of the intervention group were statistically higher than the non-intervention group (p < 0.05). The MBPST program improved functional recovery and cognitive insight in schizophrenia. In line with these results, it has been recommended that MBPST program should be provided along with medical treatment in Community Mental Health Centres.

Phytochemicals Analysis and Some Bioactive Properties of Erica manipuliflora Salisb. (EMS); Antibacterial, Antiradical and Anti-lipid Peroxidation.

In the present study, the phenolic content by using LC MS/MS method, anticholinergic, antioxidant (metal reduction, radical and removal of lipid peroxidation), and antibacterial activities of Erica manipuliflora Salisb. (EMS) extract were determined. The amount of vanillic acid, fumaric acid, catechin hydrate, quercetin, and phloridzin dihydrate were found higher than other compounds. The ethanol extract of the EMS showed an inhibition effect on the Acetylcholinesterase (AChE) enzyme with IC50 value of 0.124 ± 0.008 mg mL-1. Also, this extract of the EMS indicated radical (DPPH and ABTS) scavenging activity (about 20%) and the reducing capacity for Cu(II) and Fe(III) close to trolox, and inhibited the oxidation of linoleic acid with 40.5% at 20 µg mL-1. Antibacterial activity of the extracts was investigated against Staphylococcus aureus, Escherichia coli, and Salmonella Typhimurium using agar disc diffusion and minimum inhibitory concentration (MIC) methods. The EMS extract was found to be effective when used at least 312 mg mL-1 concentration on the pathogenic microorganisms. Consequently, it has an important non-synthetic natural content that can be used in the treatment of many diseases due to its many bioactivities such as anticholinergic, antioxidant (radical removal, lipid peroxidation prevention, etc.) and antibacterial.

The effect of mindfulness-based therapy on psychiatric symptoms, psychological well-being, and pain beliefs in patients with lumbar disk herniation.

PURPOSE: This study was conducted to determine the impact of mindfulness-based therapy on psychiatric symptoms, psychological well-being, and pain beliefs in patients with lumbar disk hernia. DESIGN AND METHODS: The study was a nonrandomized pretest-posttest controlled quasi-experimental research and carried out in a total of 64 patients. A personal information form, the Depression Anxiety Stress Scale, the Psychological Well-Being Scale, and the Pain Beliefs Scale were used for data collection. FINDINGS: We observed a statistically significant difference between the intervention and control groups in terms of the posttest mean scores of the psychiatric symptoms, psychological well-being, and pain beliefs. PRACTICE IMPLICATIONS: The results revealed that mindfulness-based therapy has a positive impact on pain beliefs and psychological well-being.

State anxiety levels of nurses providing care to patients with COVID-19 in Turkey.

PURPOSE: This study investigates the state anxiety levels of nurses providing care to patients with coronavirus disease-2019 (COVID-19) in Turkey. DESIGN AND METHODS: This cross-sectional study is based on the COVID-19 pandemic situation. The State-Trait Anxiety Inventory was used to collect the study data. FINDINGS: Nurses' state anxiety levels were high (51.51 ± 9.94). Participants evaluated for state anxiety were female; who were married; worked in intensive care units; were service nurses, having more professional experiences; and experienced hand irritation (p < 0.05). PRACTICE IMPLICATIONS: The mental health of nurses providing primary care to patients with COVID-19 should be evaluated in the long term.

The effect of sociodemographic factors on anxiety, depression, and perceived social support in patients with internal medicine and surgical problems.

PURPOSE: This study aimed to determine the effect of sociodemographic factors on anxiety, depression, and perceived social support in patients with internal medicine and surgical problems. DESIGN AND METHODS: The study comprised 522 patients who were hospitalized at the internal medicine and surgical clinics of the training and research hospital of a university. FINDINGS: Of all the patients, 27% were at the risk of anxiety and 51.7% at the risk of depression. Sociodemographic characteristics, health-related issues, and disease characteristics, besides hospitalization-related matters, affected anxiety, depression, and social support levels of patients. PRACTICE IMPLICATIONS: It was determined that more than half of the patients were at the risk of depression. Perceived social support is essential to reduce the risk of anxiety and depression.

The effects of group mindfulness-based cognitive therapy in nursing students: A quasi-experimental study.

BACKGROUND: Academic and clinical stressors are experienced by most nursing students enrolled in a nursing education program. The students who cannot effectively deal with these stressors experience stress, anxiety and depression. OBJECTIVE: The aim of this study was to determine the effects of group mindfulness-based cognitive therapy on mindfulness, depression, anxiety, and stress levels in nursing students. DESIGN: This quasi-experimental study was carried out using a nonrandomized control group pre-test, post-test, and follow up design. SETTING: Department of Nursing, Faculty of Health Sciences, University of Aksaray, Turkey. PARTICIPANTS: Eighty-two second-year undergraduate university nursing students. METHODS: The group mindfulness-based cognitive therapy program was conducted with the experimental group. The Mindful Attention Awareness Scale (MAAS) and The Depression, Anxiety and Stress Scale (DASS) were measured at pre- and post- intervention, and at a 4-months follow-up. RESULTS: The post-test mean scores of MAAS of the experimental group were statistically higher than the control group (p = .006). When the mean scores obtained in the pre-test, post-test and follow-up measurements were compared, the mean scores of MAAS increased (p = .000) and stress scores decreased significantly in the experimental group (p = .004). CONCLUSION: A group mindfulness-based cognitive therapy program conducted with nursing students had an effect on students' mindful attention awareness and stress levels. These study results indicate that this program can be used to reduce the levels of stress in nursing students.