[Effect of soil moisture on efficacy to eliminate dampness and relieve jaundice and flavonoid content of Sedum sarmentosum].

The growth environment of medicinal plants plays an important role in the formation of their medicinal quality. However, there is a lack of combined analysis studying the close relationship between the growth environment, chemical components, and related biological activities of medicinal plants. Therefore, this study investigated the effect of different soil moisture treatments on the efficacy to eliminate dampness and relieve jaundice and the flavonoid content of Sedum sarmentosum, and explored their correlation. The flavonoid content in the decoction of S. sarmentosum growing under field conditions with soil moisture levels of 35%-40%(T1), 55%-60%(T2), 75%-80%(T3), and 95%-100%(T4) was compared. The effects of these treatments on liver function parameters, liver inflammation, and oxidative damage in mice with dampness-heat jaundice were evaluated, and the correlation between pharmacological indicators and flavonoid content was analyzed. The results showed that the total flavonoid and total phenolic acid content in the decoction of S. sarmentosum were highest in the T1 treatment, followed by the T3 treatment. The content of quercetin, kaempferol, and isorhamnetin was highest in the T2, T1, and T3 treatments, respectively. Among the different moisture treatments, the T3 group of S. sarmentosum effectively reduced the levels of serum ALT, AKP, TBIL, DBIL, TBA, as well as hepatic TNF-α and IL-6 in mice with jaundice, followed by T2 treatment, especially in reducing AST level. The T4 treatment had the poorest effect. Correlation analysis showed a significant negative correlation between AST, ALT, AKP levels in mice and the total content of quercetin and the three flavonoids. MDA showed a significant negative correlation with the total flavonoid content and kaempferol. TNF-α exhibited a significant negative correlation with the content of isorhamnetin. In conclusion, S. sarmentosum growing under field conditions with a soil moisture level of 75%-80% exhibited the best efficacy to eliminate dampness and relieve jaundice. This study provides insights for optimizing the cultivation mode of medicinal plants guided by pharmacological experiments.

Association Between Glycosylated Hemoglobin Level and the Degree of Coronary Artery Disease in Patients With Stable Coronary Artery Disease and Type 2 Diabetes Mellitus / 中国循环杂志

Objectives: To explore the association between HbA1c level and the degree of coronary artery disease in patients with stable coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM). Methods: A total of 3 068 patients with stable coronary artery disease and T2DM treated with percutaneous coronary intervention (PCI) from 2014-07 to 2015-06 in Fuwai hospital were included in this retrospective study. Patients were divided into three groups according to SYNTAX score: mild lesions group (SYNTAX score: 0 to 22, n=2 661),moderate lesion group (SYNTAX score: 23 to 32, n=342), and severe lesion group (SYNTAX score > 32, n=65). The relationship between the level of HbA1c and the severity of coronary lesions in patients with T2DM was analyzed using ordered Logistic regression. Results: There were 65 (2.1%) patients with SYNTAX score> 32 and 407 (13.3%) patients with SYNTAX score >22. In SYNTAX score > 32 group, mostly patients had advanced age,longer duration of hyperlipidemia and coronary disease, higher percent of old myocardial infarction and family history of coronary artery disease. Blood glucose levels and HbA1c levels increased and left ventricular ejection fraction decreasedin proportion with increasing SYNTAX score. Patients with SYNTAX score between 23 and 32 had the highest percent of the left anterior descending coronary artery and right coronary artery lesion, followed by left circumflex artery and left main trunk lesion. However, in patients with SYNTAX score> 32, the right coronary artery was the most common culprit artery. The incidence of coronary chronic total occlusions, mean lesion number and the average number of stents increased in proportion with increasing SYNTAX score (P<0.001). Multiple regression analysis showed that HbA1c level (OR:3.51,95%CI:2.90-4.25,P<0.001), duration of CAD (OR:1.06,95%CI:1.01-1.10,P<0.01) and current smoking (OR:1.49, 95%CI: 1.27-1.89,P<0.05)were positively associated with the severity of coronary artery lesions. Conclusions: Diffuse and severe multiple coronary artery lesions are the characteristic changes of patients with stable CAD complicating T2DM.HbA1c level is an important risk factor affecting the complexity and severity of the coronary artery lesions in these patients.