A multifunctional sensor for real-time monitoring and pro-healing of frostbite wounds.

Flexible epidermal sensors based on conductive hydrogels hold great promise for various applications, such as wearable electronics and personal healthcare monitoring. However, the integration of conductive hydrogel epidermal sensors into multiple applications remains challenging. In this study, a multifunctional PAAm/PEG/hydrolyzed keratin (Hereinafter referred to as HK)/MXene conductive hydrogel (PPHM hydrogel) was designed as a high-performance therapeutic all-in-one epidermal sensor. This sensor not only accelerates wound healing but also provides wearable human-computer interaction. The developed sensor possesses highly sensitive sensing properties (Gauge Factor = 4.82 at high strain), strong mechanical tensile properties (capable of achieving a maximum elongation at break of 600 %), rapid self-healing capability, stable self-adhesive capability, biocompatibility, freeze resistance at -20 °C, and adjustable photo-thermal conversion capability. This therapeutic all-in-one sensor can sensitively monitor human movements, enabling the detection of small electrophysiological signals for diagnosing relevant activities and diseases. Furthermore, using a rat frostbite model, we demonstrated that the composite hydrogel sensor can serve as an effective wound dressing to accelerate the healing process. This study serves as a valuable reference for the development of multifunctional flexible epidermal sensors for personal smart health monitoring. STATEMENT OF SIGNIFICANCE: Accelerated wound healing reduces the risk of wound infection, and conductive hydrogel-based sensors can monitor physiological signals. The multifunctional application of conductive hydrogel sensors combined with wound diagnostic and therapeutic capabilities can meet personalized medical requirements for wound healing and sensor monitoring. The aim of this study is to develop a multifunctional hydrogel patch. The multifunctional hydrogel can be assembled into a flexible wearable high-performance diagnostic and therapeutic integrated sensor that can effectively accelerate the healing of frostbite wounds and satisfy the real-time monitoring of multi-application scenarios. We expect that this study will inform efforts to integrate wound therapy and sensor monitoring.

Attractiveness Evaluation and Identity of Self-face: The Effect of Sexual Dimorphism.

The present study aims to explore the influence of masculine/feminine changes on the attractiveness evaluation of one's own face, and examine the relationship of this attractiveness evaluation and the similarities between masculine/feminine faces and original faces. A picture was taken from each participant and considered as his or her original self-face, and a male or female face with an average attractiveness score was adopted as the original other face. Masculinized and feminized transformations of the original faces (self-face, male other face, and female other face) into 100% masculine and feminine faces were produced with morphing software stepping by 2%. Thirty female participants and 30 male participants were asked to complete three tasks, i.e., to "like" or "not like" the original face judgment of a given face compared to the original face, to choose the most attractive face from a morphed facial clip, and to subjectively evaluate the attractiveness and similarity of morphed faces. The results revealed that the acceptable range of masculine/feminine transformation for self-faces was narrower than that for other faces. Furthermore, the attractiveness ratings for masculinized or femininized self-faces were correlated with the similarity scores of the faces with the original self-faces. These findings suggested that attractiveness enhancement of self-face through masculinity/femininity must be within reasonable extent and take into account the similarity between the modified faces and the original self-face.