Neoadjuvant Immune Checkpoint Inhibitors in hepatocellular carcinoma: a meta-analysis and systematic review.

Background: Neoadjuvant immunotherapy has demonstrated beneficial outcomes in various cancer types; however, standardized protocols for neoadjuvant immunotherapy in hepatocellular carcinoma (HCC) are currently lacking. This systematic review and meta-analysis aims to investigate the reliability of neoadjuvant immunotherapy's efficacy and safety in the context of HCC. Methods: A systematic search was conducted across PubMed (MEDLINE), EMBASE, the Web of Science, the Cochrane Library, and conference proceedings to identify clinical trials involving resectable HCC and neoadjuvant immunotherapy. Single-arm meta-analyses were employed to compute odds ratios and 95% confidence intervals (CIs). Heterogeneity analysis, data quality assessment, and subgroup analyses based on the type of immunotherapy drugs and combination therapies were performed. This meta-analysis is registered in PROSPERO (identifier CRD42023474276). Results: This meta-analysis included 255 patients from 11 studies. Among resectable HCC patients, neoadjuvant immunotherapy exhibited an overall major pathological response (MPR) rate of 0.47 (95% CI 0.31-0.70) and a pathological complete response (pCR) rate of 0.22 (95% CI 0.14-0.36). The overall objective response rate (ORR) was 0.37 (95% CI 0.20-0.69), with a grade 3-4 treatment-related adverse event (TRAE) incidence rate of 0.35 (95% CI 0.24-0.51). Furthermore, the combined surgical resection rate was 3.08 (95% CI 1.66-5.72). Subgroup analysis shows no significant differences in the efficacy and safety of different single-agent immunotherapies; the efficacy of dual ICIs (Immune Checkpoint Inhibitors) combination therapy is superior to targeted combined immunotherapy and monotherapy, while the reverse is observed in terms of safety. Discussion: Neoadjuvant immunotherapy presents beneficial outcomes in the treatment of resectable HCC. However, large-scale, high-quality experiments are warranted in the future to provide robust data support.

Revealing the room temperature superplasticity in bulk recrystallized molybdenum.

Body-centered cubic refractory metallic materials exhibit excellent high-temperature strength, but often suffer from brittle intergranular fracture due to the recrystallization-induced enrichment of trace elements at grain boundaries (GBs). Here, we report a fully-recrystallized pure molybdenum (Mo) material with room temperature (RT) superplasticity, fabricated by a facile method of powder metallurgy, Y-type hot rolling and annealing. By engineering the ultralow concentration of O at GBs, the inherent GB brittleness of Mo can be largely eliminated, which, in conjunction with high fractions of soft texture and low angle GBs, enables a significant development of ordered dislocation networks and the effective dislocation transmission across low angle GBs. Synergy of these factors greatly suppress the brittle intergranular fracture of Mo, contributing to an enhanced deformability of 108.7% at RT. These findings should have general implication for fabricating a broad class of refractory metals and alloys toward harsh applications.

Exploring the pathogenesis of colorectal carcinoma complicated with hepatocellular carcinoma via microarray data analysis.

Background: Despite the increasing number of research endeavors dedicated to investigating the relationship between colorectal carcinoma (CRC) and hepatocellular carcinoma (HCC), the underlying pathogenic mechanism remains largely elusive. The aim of this study is to shed light on the molecular mechanism involved in the development of this comorbidity. Methods: The gene expression profiles of CRC (GSE90627) and HCC (GSE45267) were downloaded from the Gene Expression Omnibus (GEO) database. After identifying the common differentially expressed genes (DEGs) of psoriasis and atherosclerosis, three kinds of analyses were performed, namely, functional annotation, protein-protein interaction (PPI) network and module construction, and hub gene identification, survival analysis and co-expression analysis. Results: A total of 150 common downregulated differentially expressed genes and 148 upregulated differentially expressed genes were selected for subsequent analyses. The significance of chemokines and cytokines in the pathogenesis of these two ailments is underscored by functional analysis. Seven gene modules that were closely connected were identified. Moreover, the lipopolysaccharide-mediated signaling pathway is intricately linked to the development of both diseases. Finally, 10 important hub genes were identified using cytoHubba, including CDK1, KIF11, CDC20, CCNA2, TOP2A, CCNB1, NUSAP1, BUB1B, ASPM, and MAD2L1. Conclusion: Our study reveals the common pathogenesis of colorectal carcinoma and hepatocellular carcinoma. These common pathways and hub genes may provide new ideas for further mechanism research.

Improving the HCHO Sensing Selectivity on Ag-Doped Graphene by Oxygen Functionalization: A First-Principles Study.

Graphene-based sensors typically fail in the selectivity of target gas detection when exposed to complex and multicompound atmospheres. We have thoroughly compared the adsorptions of various interfering gases (CO, NH3, CH4, C2H2, C2H4, CH3OH, and CH3Cl) with target HCHO on AgG and AgOG by first-principles simulations. The results demonstrate that AgG shows a poor selectivity for HCHO detection and an oxygen functionalized one can improve the selectivity by enhancing the adsorption strength of HCHO and weakening those of other gas molecules. Moreover, the sensing properties of the AgOG sensors are evaluated by the NEGF method, and the predicted HCHO sensing responses are 76 and 32% along the armchair and zigzag directions, respectively. The present work helps shed some light on designing graphene-based sensing materials with high selectivity.

Tunable formaldehyde sensing properties of palladium cluster decorated graphene.

The ability to tune the adsorption strength of the targeted gas on sensing materials is crucial for sensing applications. By employing first-principles calculations the adsorption and sensing properties of HCHO on small Pd n (n = 1-6) cluster decorated graphene have been systematically investigated. The adsorption energy is found to depend on the size of the Pd n cluster and can be tuned in a wide range from -0.68 eV on Pd(111) to -1.98 eV on the Pd3/graphene system. We also find that the Pd n /graphene (n = 5 and 6) systems have an appropriate adsorption energy for HCHO gas sensing. The current-voltage curves are calculated by the non-equilibrium Green's function method for the two-probe nano-sensor devices along both the armchair and zigzag directions. The devices constructed with Pd n /graphene (n = 5 and 6), having the highest absolute response over 20% at small voltages, should be applicable for HCHO detection. This work provides a theoretical basis for exploring potential applications of metal cluster decorated graphene for gas sensing.

Synthesis, electronic structures, and photoluminescence properties of an efficient and thermally stable red-emitting phosphor Ca3ZrSi2O9:Eu3+,Bi3+ for deep UV-LEDs.

A series of red-emitting Ca3ZrSi2O9:Eu3+,xBi3+ phosphors was synthesized using a conventional high temperature solid-state reaction method, for the purpose of promoting the emission efficiency of Eu3+ in a Ca3ZrSi2O9 host. The site preference of Bi3+ and Eu3+ in the Ca3ZrSi2O9 host was evaluated by formation energy. The effects of Bi3+ on electronic structure, luminescent properties, and related mechanisms were investigated. The inner quantum yield of the optimized sample increased to 72.9% (x = 0.08) from 34.6% (x = 0) at 300 nm ultraviolet light excitation. The optimized sample (x = 0.08) also showed excellent thermal stability, and typically, 84.2% of the initial emission intensity was maintained when the temperature increased to 150 °C from 25 °C, which is much higher than that without Bi3+ doping (70.1%). The mechanisms of emission properties and thermal stability enhancement, as well as the redshift of the charge transfer band (CTB) induced by Bi3+ doping in the Ca3ZrSi2O9:Eu3+ phosphor, were discussed. This study elucidates the photoluminescence properties of Bi3+-doped Ca3ZrSi2O9:Eu3+ phosphor, and indicates that it is a promising luminescent material that can be used in ultraviolet light-emitting diodes.