The Quartet Data Portal: integration of community-wide resources for multiomics quality control.

The Quartet Data Portal facilitates community access to well-characterized reference materials, reference datasets, and related resources established based on a family of four individuals with identical twins from the Quartet Project. Users can request DNA, RNA, protein, and metabolite reference materials, as well as datasets generated across omics, platforms, labs, protocols, and batches. Reproducible analysis tools allow for objective performance assessment of user-submitted data, while interactive visualization tools support rapid exploration of reference datasets. A closed-loop "distribution-collection-evaluation-integration" workflow enables updates and integration of community-contributed multiomics data. Ultimately, this portal helps promote the advancement of reference datasets and multiomics quality control.

Intrarenal small artery thrombosis in a transplant recipient patient infected with Covid-19 after kidney transplantation: A rare case report.

Currently, renal arteriovenous thrombosis induced by Covid-19 infection in patients after renal transplantation is very rare. We present a recent kidney transplant recipient who developed Covid-19 infection and later developed intrarenal small artery thrombosis. Finally, the patient's respiratory tract infection symptoms gradually disappeared after treatment. However, hemodialysis replacement therapy has to be continued due to the injury of the transplanted kidney function. In this case, we first reported that Covid-19 infection may induce intrarenal small artery thrombosis after kidney transplantation, which caused local ischemic necrosis of the transplanted kidney. We found that patients are at a high risk of Covid-19 infection at the early stage after kidney transplantation, and their clinical symptoms may be severe. In addition, even with anticoagulant therapy, Covid-19 infection may still increase the risk of thrombosis to some extent for patients who have undergone kidney transplantation, and we need to be alert to this rare complication in the future clinical work.

No detected toxic concentrations in in situ algal growth inhibition tests--a convenient approach to aquatic ecotoxicology.

A newly proposed three-dimensional model for the effects of heavy metals on the growth of batch cultures of algae that allows the estimation of the no detected toxic effect concentration (NDEC) is presented. Two batch assays with exposure to copper were investigated in situ. As an endpoint in the in situ studies of ecotoxicology, the carrying capacity, a parameter of the logistic growth model, possesses higher sensitivity and reliability than the routine ecotoxicological endpoints in terms of the analysis based on the theoretical arguments and experimental results. Using the carrying capacity (B(f)) as the ecotoxicological endpoint, the NDEC from the proposed model is compared to the NOEC and EC(05) on the basis of field derived data. The results indicate that the NDEC is a promising possible alternative parameter to the NOEC.