Mechanism and tuning sensitivity of symmetry-protected resonances in high-contrast gratings.

We develop a theory of refractive index tuning for symmetry-protected optical bound states (SP-BICs) in high-contrast gratings (HCGs). A compact analytical formula for tuning sensitivity is derived and verified numerically. We also discover a new type of SP-BIC in HCGs that has an accidental nature with a spectral singularity, which is explained in terms of hybridization and strong coupling among the odd- and even-symmetric waveguide-array modes. Our work elucidates the physics of tuning SP-BICs in HCGs and significantly simplifies their design and optimization for dynamic applications in light modulation, tunable filtering, and sensing.

Characteristics of Optic Disc and Visual Field Changes in Patients with Thyroid-Associated Orbitopathy and Open-Angle Glaucoma.

This study aimed to characterize the changes in the visual field (VF) patterns and disc morphology of patients with thyroid-associated orbitopathy (TAO) and open-angle glaucoma (OAG). A retrospective review of the medical records at the Tri-Service General Hospital in Taiwan identified 396 eyes of 198 patients with thyroid-associated glaucoma. A final follow-up of VF examination in 140 eyes revealed 114 eyes with VF defects, indicating disease progression. The characteristics of and changes in disc morphology, optical coherence tomography findings, and VF defects were statistically analyzed. The most common VF defects at the initial diagnosis and the end of the follow-up period were inferior partial arcuate (17%) and paracentral (15%) defects, respectively. The most common VF defect in patients with unspecific disc signs was an unspecific scotoma (13%). The most common optic disc feature was disc cupping (51%), followed by parapapillary atrophy (48%). The most frequent location of nerve fiber layer thinning was the inferotemporal region (48%). VF defects showed a significantly more pronounced progression in the non-nerve fiber bundle group than in the nerve fiber bundle group (p < 0.001). This study details the characteristics and progression of disc morphology and VF defects in patients with TAO and OAG.

Dielectric Properties of BaTiO3-Epoxy Nanocomposites in the Microwave Regime.

We synthesized BaTiO3-epoxy nanocomposites (particle size < 100 nm) with volume fractions up to 25 vol. %, whose high-frequency complex permittivity was characterized from 8.2 to 12.5 GHz. The maximum dielectric constant approaches 9.499 with an acceptable loss tangent of 0.113. The dielectric loss gradually saturates when the particle concentration is higher than 15 vol. %. This special feature is an important key to realizing high-k and low-loss nanocomposites. By comparing the theoretical predictions and the experimental data, four applicable effective-medium models are suggested. The retrieved dielectric constant (loss tangent) of 100-nm BaTiO3 nanopowder is in the range of 50-90 (0.1-0.15) at 8.2-12.5 GHz, exhibiting weak frequency dispersion. Two multilayer microwave devices-total reflection and antireflection coatings-are designed based on the fabricated nanocomposites. Both devices show good performance and allow broadband operation.

Mechanism and sensitivity of Fano resonance tuning in high-contrast gratings.

We develop a theory for Fano resonance tuning in dual-mode high-contrast gratings (HCGs). Compact analytical formulas of tuning sensitivity are derived and verified numerically, and are in good agreement with reported experiments. We show that the resonance tuning in HCGs, containing cooperative contribution from two propagating modes, is fundamentally different from that in single-mode microresonators. Our theory reveals the important role of the higher-order mode, which can possess large modal dispersion, especially in the long-wavelength limit beyond the cutoff of slab waveguides, to enable large tuning sensitivity. Our findings will simplify the design and optimization of active and passive tuning in HCG resonators.

Nonlinear and self-consistent single-mode formulation for TM-mode gyrotrons.

This work develops a nonlinear and self-consistent framework for the single-mode simulation of TM-mode gyrotrons. Unlike TE modes, a nonlinear TM wave equation is derived by considering the additional axial modulation on the electron beam due to the interaction with the axial electric field. Together with the electrons' equations of motion, particle tracing simulation is conducted to model TM-mode oscillation. For a uniform structure, the electron-beam efficiency of the TM_{11}-mode gyrotron at the W band can achieve 30% over broad parameter space. Its beam-current, beam-voltage, and pitch-factor tuning properties are investigated under different magnetic fields. By optimizing the interaction structure of the proposed gyrotron backward-wave oscillator (gyro-BWO), the maximum interaction efficiency is higher than 30% with a frequency tuning range of more than 6 GHz at the pitch factor of 1.5. The peak efficiency can remain high of 32% at low beam voltage (10 kV) and low magnetic field (32.8 kG), indicating additional operating conditions. These special features may facilitate the development of low-cost and compact gyrotron systems and show great potential in the applications for TM-mode gyro-BWOs.

Fast, Nondestructive, and Broadband Dielectric Characterization for Polymer Sheets.

We propose a compact nearfield scheme for fast and broadband dielectric characterization in the microwave region. An open-type circular probe operated in the high-purity TE01 mode was developed, showing a strongly confined fringing field at the open end. This fringing field directly probed the freestanding sheet sample, and the overall reflection was measured. Without sample-loading processes, both of the system assembling time and the risk of sample damage can be significantly reduced. In addition, the nearfield measurement substantially simplifies the calibration and the retrieval theory, facilitating the development of easy-to-integrate and easy-to-calibrate dielectric characterization technique. The dielectric properties of more than ten polymers were characterized from 30 GHz to 40 GHz. We believe that this work fulfills the requirement of the fast diagnostic in the industrial manufactures and also provides valuable high-frequency dielectric information for the designs of 5G devices.

Hyperspectral Ophthalmoscope Images for the Diagnosis of Diabetic Retinopathy Stage.

A methodology that applies hyperspectral imaging (HSI) on ophthalmoscope images to identify diabetic retinopathy (DR) stage is demonstrated. First, an algorithm for HSI image analysis is applied to the average reflectance spectra of simulated arteries and veins in ophthalmoscope images. Second, the average simulated spectra are categorized by using a principal component analysis (PCA) score plot. Third, Beer-Lambert law is applied to calculate vessel oxygen saturation in the ophthalmoscope images, and oxygenation maps are obtained. The average reflectance spectra and PCA results indicate that average reflectance changes with the deterioration of DR. The G-channel gradually decreases because of vascular disease, whereas the R-channel gradually increases with oxygen saturation in the vessels. As DR deteriorates, the oxygen utilization of retinal tissues gradually decreases, and thus oxygen saturation in the veins gradually increases. The sensitivity of diagnosis is based on the severity of retinopathy due to diabetes. Normal, background DR (BDR), pre-proliferative DR (PPDR), and proliferative DR (PDR) are arranged in order of 90.00%, 81.13%, 87.75%, and 93.75%, respectively; the accuracy is 90%, 86%, 86%, 90%, respectively. The F1-scores are 90% (Normal), 83.49% (BDR), 86.86% (PPDR), and 91.83% (PDR), and the accuracy rates are 95%, 91.5%, 93.5%, and 96%, respectively.

Bright and Ultrafast Photoelectron Emission from Aligned Single-Wall Carbon Nanotubes through Multiphoton Exciton Resonance.

Ultrashort bunches of electrons, emitted from solid surfaces through excitation by ultrashort laser pulses, are an essential ingredient in advanced X-ray sources, and ultrafast electron diffraction and spectroscopy. Multiphoton photoemission using a noble metal as the photocathode material is typically used but more brightness is desired. Artificially structured metal photocathodes have been shown to enhance optical absorption via surface plasmon resonance but such an approach severely reduces the damage threshold in addition to requiring state-of-the-art facilities for photocathode fabrication. Here, we report ultrafast photoelectron emission from sidewalls of aligned single-wall carbon nanotubes. We utilized strong exciton resonances inherent in this prototypical one-dimensional material, and its excellent thermal conductivity and mechanical rigidity leading to a high damage threshold. We obtained unambiguous evidence for resonance-enhanced multiphoton photoemission processes with definite power-law behaviors. In addition, we observed strong polarization dependence and ultrashort photoelectron response time, both of which can be quantitatively explained by our model. These results firmly establish aligned single-wall carbon nanotube films as novel and promising ultrafast photocathode material.

Nitric oxide levels in the aqueous humor vary in different ocular hypertension experimental models.

This study investigated the relationships among intraocular pressure (IOP), nitric oxide (NO) levels, and aqueous flow rates in experimental ocular hypertension models. A total of 75 rabbits were used. One of four different materials [i.e., α-chymotrypsin, latex microspheres (Polybead), red blood cell ghosts, or sodium hyaluronate (Healon GV)] was injected into the eyes of the 15 animals in each experimental group; the remaining 15 rabbits were reserved for a control group. The IOP changes in the five groups were recorded on postinduction Days 1-3, Day 7, Day 14, Day 30, Day 60, Day 90, and Day 120. On postinduction Day 7, the dynamics and NO levels in the aqueous humor were recorded. Significant IOP elevations were induced by α-chymotrypsin (p < 0.01) and Polybead (p < 0.01) on each postinduction day. In the red blood cell ghosts model, significant elevations (p < 0.01) were found on postinduction Days 1-3; Healon GV significantly elevated IOP (p < 0.01) on postinduction Day 1 and Day 2. On postinduction Day 7, the aqueous humor NO levels increased significantly in the models of α-chymotrypsin, Polybead, and red blood cell ghosts (all p < 0.01), while the aqueous flow rates were significantly reduced in the models of α-chymotrypsin and Polybead (p < 0.005). Persistent ocular hypertension models were induced with α-chymotrypsin and Polybead in the rabbits. The Polybead model exhibited the characteristic of an increased aqueous humor NO level, similar to human eyes with acute angle-closure glaucoma and neovascular glaucoma.