RESUMEN
BACKGROUND: Neurofibromas are benign tumors of a neurogenic origin. If these tumors occur without any other signs of neurofibromatosis, they are classified as isolated neurofibromas. Neurofibromas in the oral cavity mostly occur within soft tissues, indicating that solitary intraosseous neurofibromas in the mandible are rare. Due to the absence of specific clinical manifestations, early diagnosis and treatment of these tumors are difficult to achieve. CASE SUMMARY: A 37-year-old female patient visited our hospital due to numbness and swelling of the gums in the right lower molar area that had persisted for half a month. The patient's overall condition and intraoral examination revealed no significant abnormalities. She was initially diagnosed with a cystic lesion in the right mandible. However, after a more thorough examination, the final pathological diagnosis was confirmed to be neurofibroma. Complete tumor resection and partial removal of the right inferior alveolar nerve were performed. As of writing this report, there have been no signs of tumor recurrence for nine months following the surgery. CONCLUSION: This case report discusses the key features that are useful for differentiating solitary intraosseous neurofibromas from other cystic lesions.
RESUMEN
The occurrence and prognosis of head and neck squamous cell cancer (HNSC) is closely associated with human papillomavirus (HPV) infection. Transmembrane channel-like 8 (TMC8) is a key gene affecting the susceptibility of HPV and that plays an important role in T cell regulation. However, the mechanism by which TMC8 affects T cells and whether it further affects the prognosis of patients with HNSC remains unclear. In the present study, oral cancer cell lines and independent tumor specimens were used to detect TMC8 expression in HNSC. Differential expression of TMC8, methylation status, function and associated signaling pathways were further analyzed. Then, multiple databases were cross-analyzed for the relationship of TMC8 with immune cell infiltration and its impact on the prognosis of numerous types of cancer. The results showed that TMC8 was upregulated in HNSC and high expression was predictive of an improved prognosis. Furthermore, TMC8 was concentrated in multiple immune-associated signaling pathways and the expression of TMC8 was associated with the infiltration of CD4+ T cells and their subsets, including CD8+ T cells, B cells and macrophages, suggesting that TMC8 may play an anti-HPV role by regulating CD4+ T cells. Thus, TMC8 plays an anti-HPV role by regulating the infiltration level of CD4+ T cells, and could therefore be used as a potential prognostic marker for patients with HNSC.
RESUMEN
PURPOSE: To evaluate the clinical effect of continuous curvilinear buccal-cervical incision in combined radical resection of buccal cancer. METHODS: From January 2015 to December 2018, a total of 87 patients with buccal cancer were collected, of whom 42 underwent continuous curvilinear buccal-cervical incision (experimental group) and 45 underwent conventional cervical T shaped incision combined with a buccal incision (control group). Exposure of surgical filed in two groups was evaluated. The length of incision, duration of radical resection, and the incidence of postoperative complications were compared between two groups. The patients were followed-up for 7-43 months. Modified vancouver scar scale (VSS) and University of Washington Quality of Life (UW-QOL) were used to evaluate the postoperative scar and quality of life in both groups. Statistical analysis was performed on the data using SPSS 22.0 software package. RESULTS: The length of the incision in the experimental group was (36.40±5.08) cm, which was shorter than that of the control group (39.93±5.22) cm. Duration of combined radical resection in the experimental group was shorter than that of the control group. The incidence of neck complications in the experimental group was lower than that of the control group. The postoperative scar assessment and quality of life of the experimental group were better than that of the control group. The difference was statistically significant (P<0.05). There was no significant difference between the two groups in terms of the exposure of the surgical field, postoperative recurrence and metastasis rate. CONCLUSIONS: Continuous curvilinear buccal-cervical incision has good exposure of the surgical field and shorter duration of radical resection, which ensures en bloc resection of tumor and cervical lymph nodes. It limits the formation of skin cicatrix, reduces the occurrence of postoperative complications and results in a good aesthetic and functional effect, therefore it is a recommended incision for clinical practice.
