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1.
Am J Mens Health ; 18(1): 15579883231223366, 2024.
Artículo en Inglés | MEDLINE | ID: mdl-38293721

RESUMEN

Numerous case reports exist on penile strangulation injuries and extrication methods; however, the care and long-term consequences of penile strangulation injuries have been under-reported. Our aim is to investigate the long-term outcomes and sequalae following penile strangulation injuries. The PubMed Medline database was searched using the keyword string "penile strangulation," "penis strangulation," and "constriction" for all studies reporting outcomes of published penile strangulation injuries. Articles were evaluated for follow-up after strangulation injury, strangulating agent, extricating agent, and sequelae of injury. Fifty-six studies resulted with reports of 100 cases of penile strangulation and extrication from January 2000 to December 2019. The mean patient age was 41 (range: 3-86) years. Twenty-four (24/100) cases reported sequalae following extrication. Follow-up ranged from 2 weeks to 7 years with median follow-up time in the 7- to 12-month grouping. Metal rings comprised 36% (36/100) of strangulation agents and 50% of reported incidents were attributed to sexual activity. To our knowledge, this is the only study focusing on long-term outcomes after penile strangulation. This review provides a summary of 56 studies that document penile strangulation injuries over the last 20 years. Although a wide array of penile strangulation injuries have been documented in the literature, reports lack secondary management and long-term outcomes after removal of the strangulation device. We recommend that providers report long-term penile strangulation outcomes for future urologic evaluations after extrication.


Asunto(s)
Enfermedades del Pene , Pene , Masculino , Humanos , Preescolar , Niño , Adolescente , Adulto Joven , Adulto , Persona de Mediana Edad , Anciano , Anciano de 80 o más Años , Estudios de Seguimiento , Pene/cirugía , Enfermedades del Pene/etiología , Enfermedades del Pene/cirugía , Conducta Sexual , Constricción Patológica/etiología
2.
BMC Surg ; 23(1): 22, 2023 Jan 27.
Artículo en Inglés | MEDLINE | ID: mdl-36707832

RESUMEN

BACKGROUND: The kidney is the most frequently injured component of the genitourinary system, accounting for 5% of all trauma cases. Several guidelines by different societies address the management of urological trauma. However, unanswered questions remain regarding optimal use of angioembolization in hemodynamically stable patients, indications for operative exploration of stable retroperitoneal hematomas and renal salvage techniques in the setting of hemodynamic instability, and imaging practices for patients undergoing non-operative management. We performed a systematic review, meta-analysis, and developed evidence-based recommendations to answer these questions in both blunt and penetrating renal trauma. METHODS: The working group formulated four population, intervention, comparator, outcome (PICO) questions regarding the following topics: (1) angioembolization (AE) usage in hemodynamically stable patients with evidence of ongoing bleeding; (2) surgical approach to stable zone II hematomas (exploration vs. no exploration) in hemodynamically unstable patients and (3) surgical technique (nephrectomy vs. kidney preservation) for expanding zone II hematomas in hemodynamically unstable patients; (4) frequency of repeat imaging (routine or symptom based) in high-grade traumatic renal injuries. A systematic review and meta-analysis of currently available evidence was performed. RevMan 5 (Cochran Collaboration) and GRADEpro (Grade Working Group) software were used. Recommendations were voted on by working group members and concurrence was obtained for each final recommendation. RESULTS: A total of 20 articles were identified and analyzed. Two prospective studies were encountered; the majority were retrospective, single-institution studies. Not all outcomes projected by PICO questions were reported in all studies. Meta-analysis was performed for all PICO questions except PICO 3 secondary to the discrepant patient populations included in those studies. PICO 1 had the greatest number of articles included in the meta-analysis with nine studies; yet, due to differences in study design, no critical outcomes emerged; similar differences among a smaller set of articles prevented observation of critical outcomes for PICO 4. Analyses of PICOs 2 and 3 favored a non-invasive or minimally invasive approach in-line with current international practice trends. CONCLUSION: In hemodynamically stable adult patients with clinical or radiographic evidence of ongoing bleeding, no recommendation could be made regarding the role of AE vs. observation. In hemodynamically unstable adult patients, we conditionally recommend no renal exploration vs. renal exploration in stable zone II hematomas. In hemodynamically unstable adult patients, we conditionally recommend kidney preserving techniques vs. nephrectomy in expanding zone II hematomas. No recommendation could be made for the optimal timing of repeat imaging in high grade renal injury. LEVEL OF EVIDENCE: Guideline; systematic review, level III.


Asunto(s)
Heridas no Penetrantes , Heridas Penetrantes , Humanos , Adulto , Estudios Retrospectivos , Estudios Prospectivos , Heridas no Penetrantes/complicaciones , Riñón/diagnóstico por imagen , Riñón/cirugía , Heridas Penetrantes/cirugía , Hemorragia , Hematoma/etiología , Hematoma/cirugía
3.
Sex Med ; 9(1): 100273, 2021 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-33307340

RESUMEN

A 36-year-old African American man presented to the emergency department with 2 days of left-sided perineal pain after sexual activity. He was found to have induration in the left perineum overlying the proximal left corporal body. Clinical picture was suspicious for traumatic corporal rupture; however, advanced imaging showed a proximal segmental thrombosis of the left corpus cavernosum. The patient underwent perineal exploration with evacuation of an intracorporal penile hematoma. In spite of disrupting a fibrous membrane in the proximal corpora and drainage of the corpora, we observed repeat tumescence during the procedure because of an observed arterial high-flow state in the corpora cavernosum. This was resolved with administration of phenylephrine into the cavernosum. The patient had return of normal erectile function 2 days after the procedure with resolution of pain at the site. Singh D, Larson T, Campbell K, et al. Surgical Management of Idiopathic Partial Thrombosis of the Corpus Cavernosum. Sex Med 2021;9:100273.

4.
J Endourol Case Rep ; 6(4): 409-412, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33457687

RESUMEN

Background: Chyluria is a rare diagnosis classically associated with milky-appearing urine. It involves the leakage of chyle into the urinary tract. Although the most common cause of chyluria worldwide is infectious in nature, other noninfectious etiologies have been described. Classically chyluria resolves spontaneously or with conservative management. Surgical treatments have been described but are not often required. We present a case of iatrogenic pyelolymphatic fistula after robot-assisted laparoscopic dismembered pyeloplasty that was treated with endoscopic electrocautery of the fistulous tract. Case Presentation: A 50-year-old Caucasian man underwent a robot-assisted laparoscopic dismembered pyeloplasty with stent insertion for radiographically demonstrated left ureteropelvic junction obstruction. His postoperative course was uneventful until 4-week follow-up at which time he began to notice intermittent passage of milky-appearing urine. Urinalysis was notable for large protein and elevated urine triglycerides. He was initially managed conservatively dietary modifications without success. He then underwent endoscopic management with cystoscopy and ureteroscopy with fulguration of suspected pyelolymphatic fistula. He was maintained on a low-fat medium-chain triglyceride diet and octreotide injections while inpatient for 1 week postoperatively. His postoperative course was unremarkable and no return of chyluria was observed. His chyluria remained resolved at 9 months postoperatively. Conclusion: Pyelolymphatic fistula after robot-assisted laparoscopic pyeloplasty is a theoretical complication of perirenal dissection and has not been previously described in the literature. It should be considered as a rare iatrogenic cause of chyluria. Endoscopic management with fulguration is technically feasible and may obviate the need for more invasive surgical management.

5.
J Endourol Case Rep ; 6(4): 505-508, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-33457714

RESUMEN

Background: Periureteral venous rings are a rare congenital anomaly involving the inferior vena cava (IVC) and the right ureter, where the ureter courses through a venous ring made by the duplication of the IVC during embryogenesis. This anatomic anomaly is also referred to as a transcaval ureter. Although most patients are asymptomatic and radiographic findings are incidental, some patients can be symptomatic. We present the first reported case of asymptomatic obstructive ureterolithiasis at the level of a periureteral venous ring that was effectively treated with endoscopic management. Case Presentation: A 47-year-old woman was found to have right hydroureteronephrosis on MRI. Further CT imaging showed an obstructing ureteral stone at the level of a periureteral venous ring. After initial decompression with ureteral stenting, she underwent ureteroscopy that revealed the ureteral stone at the level of the venous anomaly. The stone was fragmented and removed with laser lithotripsy and stone basket manipulation. After a period of ureteral stenting and removal, she had improved hydroureteronephrosis, no symptoms of ureteral obstruction, and stable renal function. Given these findings, she elected for surveillance with imaging in lieu of any reconstructive procedure to transpose the ureter around the venous anomaly. Conclusions: We present the first reported case of obstructive ureterolithiasis at the level of a periureteral venous ring. Our experience suggests that, with preoperative ureteral stenting, obstructing ureteral stones in the setting of an IVC anomaly can be managed with retrograde flexible ureteroscopy. Conservative laser settings and minimal torqueing of the ureteroscope are advised given adjacent vascular anomaly. Cases wherein the affected ureteral segment is too constricted or tortuous to allow for stone passage or for ureteroscopy may require management by percutaneous antegrade intervention. Surgical reconstruction of the ureter should also be considered.

6.
Neurourol Urodyn ; 38(8): 2051-2059, 2019 11.
Artículo en Inglés | MEDLINE | ID: mdl-31429982

RESUMEN

AIMS: First, to evaluate the efficacy of adjustable balloon devices or adjustable continence therapy (ProACT) in the treatment for male stress urinary incontinence (SUI). Second, to investigate the safety profile and rates of adverse events associated with the implantation of adjustable balloon devices. METHOD: A review of the literature was performed by searching the PubMed database with the most applicable search terms. We narrowed included studies with adult male patients with SUI; outcomes included pads or pad weight per day and quality of life (QOL) questionnaires, as well as safety outcomes. RESULTS: In total, 19 studies were included with a total of 1264 patients and 4517 patient-years of follow-up data (mean follow-up time 3.6 years). ProACT implantation resulted in an incontinence QOL improvement of 30.8 points from baseline. At baseline, patients on average were using 4.0 pads per day (PPD) (95% confidence interval [CI]: 2.6-5.4), which was reduced to an average of 1.1 PPD (95% CI: 0.5-1.7) after ProACT implantation. The number of patients that were considered "dry" was 60.2% (95% CI: 54.2%-65.9%) and the number of patients who were found to be either "dry" or improved greater than 50% was 81.9% (95% CI: 74%-87.8%). CONCLUSIONS: Implantation of adjustable balloon devices is efficacious and safe for the treatment of male SUI. Given the minimal invasiveness of the therapy, adjustable balloon devices may be a serious option as a first-line treatment in nonirradiated patients with SUI who are not ideal candidates for the artificial urinary sphincter.


Asunto(s)
Prostatectomía/efectos adversos , Incontinencia Urinaria de Esfuerzo/cirugía , Esfínter Urinario Artificial , Humanos , Masculino , Calidad de Vida , Encuestas y Cuestionarios , Resultado del Tratamiento , Incontinencia Urinaria de Esfuerzo/etiología
7.
Urol Case Rep ; 24: 100867, 2019 May.
Artículo en Inglés | MEDLINE | ID: mdl-31211077

RESUMEN

Non-Hodgkin lymphoma of the prostate is uncommon. Prostate specific antigen and transrectal ultrasound do not aid in diagnosis. Survival and treatment options are ultimately based on immune-histologic subtype and stage. Lower urinary tract symptoms attributed to lymphoma of the prostate can be refractory to systemic treatments as well as transurethral resection. This case provides the first description of the longitudinal clinical course of treatment-refractory localized Non-Hodgkin lymphoma of the prostate.

8.
J Trauma Acute Care Surg ; 86(2): 326-336, 2019 02.
Artículo en Inglés | MEDLINE | ID: mdl-30489505

RESUMEN

BACKGROUND: The diagnostic evaluation and clinical management of bladder injuries caused by blunt force trauma are variable. We aim to formulate a practice management guideline using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology. METHODS: The working group, patient, intervention, comparator, outcome (PICO), formulated four questions regarding the following topics: (1) diagnostic evaluation based on patient baseline risk of bladder injury (computed tomography cystography vs. no imaging); (2) management of intraperitoneal bladder injuries (operative versus nonoperative); (3) management of extraperitoneal bladder injuries based on complexity of injury (operative vs. nonoperative); and (4) diagnostic follow-up of bladder injuries based on complexity of repair (cystography vs. no cystography). A systematic review of the MEDLINE database for English language articles with adult patients was undertaken. RevMan 5 (Review Manager (RevMan) [Computer program]. Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014) and GRADEpro (GRADEpro GDT: GRADEpro Guideline Development Tool [Software]. McMaster University, 2015) software were used. Recommendations were voted on by working group members. Consensus was obtained for each recommendation. RESULTS: Three hundred ninety-three articles were screened, resulting in a full-text review of 64 articles. Seventeen articles were used to formulate the recommendations of this guideline. Several recommendations are made. The need for initial computed tomography cystography after trauma depends on characteristics of the trauma itself, but it is not recommended in patients without gross hematuria. In general, patients with intraperitoneal bladder ruptures should undergo operative repair. This is not routinely necessary in those with extraperitoneal ruptures unless the injury is complex. The need for follow-up cystography after bladder repair depends on the risk of urine leak. Those with low risk of urine leak do not require a follow-up study. CONCLUSION: Using the GRADE process, the panel made nine recommendations based on four PICO questions concerning the evaluation and management of blunt force bladder injuries.


Asunto(s)
Traumatismos Abdominales , Vejiga Urinaria/lesiones , Heridas no Penetrantes , Traumatismos Abdominales/diagnóstico , Traumatismos Abdominales/terapia , Estudios de Seguimiento , Humanos , Guías de Práctica Clínica como Asunto , Vejiga Urinaria/diagnóstico por imagen , Heridas no Penetrantes/complicaciones , Heridas no Penetrantes/diagnóstico , Heridas no Penetrantes/terapia
10.
Urol Case Rep ; 10: 60-62, 2017 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-27981037

RESUMEN

Urethroplasty may involve the use of tissue substitution including buccal mucosa graft (BMG), penile fasciocutaneous flaps, or skin grafts. Stricture recurrence and fistula formation are some uncommon complications that can result from surgery. The development of squamous cell carcinoma (SCC) after BMG substitution urethroplasty is a new complication that we encountered that has not been described in the literature. We present the first reported case of a patient who developed SCC of the buccal mucosa graft used to reconstruct the urethra.

11.
Adv Urol ; 2015: 281969, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-26576148

RESUMEN

Objective. To evaluate the recurrence rate of bulbar urethral strictures managed with cold knife direct vision internal urethrotomy and high dose corticosteroid injection. Methods. 28 patients with bulbar urethral strictures underwent direct vision internal urethrotomy with high dose triamcinolone injection into the periurethral tissue and were followed up for recurrence. Results. Our cohort had a mean age of 60 years and average stricture length of 1.85 cm, and 71% underwent multiple previous urethral stricture procedures with an average of 5.7 procedures each. Our technique modification of high dose corticosteroid injection had a recurrence rate of 29% at a mean follow-up of 20 months with a low rate of urinary tract infections. In patients who failed treatment, mean time to stricture recurrence was 7 months. Patients who were successfully treated had significantly better International Prostate Symptom Scores at 6, 9, and 12 months. There was no significant difference in maximum flow velocity on Uroflowmetry at last follow-up but there was significant difference in length of follow-up (p = 0.02). Conclusions. High dose corticosteroid injection at the time of direct vision internal urethrotomy is a safe and effective procedure to delay anatomical and symptomatic recurrence of bulbar urethral strictures, particularly in those who are poor candidates for urethroplasty.

12.
EMBO Rep ; 16(5): 654-69, 2015 May.
Artículo en Inglés | MEDLINE | ID: mdl-25802403

RESUMEN

The ETS factor ETV2 (aka ER71) is essential for the generation of the blood and vascular system, as ETV2 deficiency leads to a complete block in blood and endothelial cell formation and embryonic lethality in the mouse. However, the ETV2-mediated gene regulatory network and signaling governing hematopoietic and endothelial cell development are poorly understood. Here, we map ETV2 global binding sites and carry out in vitro differentiation of embryonic stem cells, and germ line and conditional knockout mouse studies to uncover mechanisms involved in the hemangiogenic fate commitment from mesoderm. We show that ETV2 binds to enhancers that specify hematopoietic and endothelial cell lineages. We find that the hemangiogenic progenitor population in the developing embryo can be identified as FLK1(high)PDGFRα(-). Notably, these hemangiogenic progenitors are exclusively sensitive to ETV2-dependent FLK1 signaling. Importantly, ETV2 turns on other Ets genes, thereby establishing an ETS hierarchy. Consequently, the hematopoietic and endothelial cell program initiated by ETV2 is maintained partly by other ETS factors through an ETS switching mechanism. These findings highlight the critical role that transient ETV2 expression plays in the regulation of hematopoietic and endothelial cell lineage specification and stability.


Asunto(s)
Células Sanguíneas/citología , Células Sanguíneas/metabolismo , Diferenciación Celular , Células Endoteliales/citología , Células Endoteliales/metabolismo , Factores de Transcripción/metabolismo , Animales , Sitios de Unión , Diferenciación Celular/genética , Linaje de la Célula/genética , Inmunoprecipitación de Cromatina , Femenino , Regulación del Desarrollo de la Expresión Génica , Redes Reguladoras de Genes , Células Madre Hematopoyéticas/citología , Células Madre Hematopoyéticas/metabolismo , Secuenciación de Nucleótidos de Alto Rendimiento , Inmunofenotipificación , Masculino , Ratones , Ratones Noqueados , Motivos de Nucleótidos , Especificidad de Órganos/genética , Posición Específica de Matrices de Puntuación , Unión Proteica , Receptores de Factores de Crecimiento Endotelial Vascular/metabolismo , Transducción de Señal , Factores de Transcripción/genética , Receptor 2 de Factores de Crecimiento Endotelial Vascular/metabolismo , Factores de Crecimiento Endotelial Vascular/metabolismo
13.
J Urol ; 193(4): 1153-8, 2015 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-25451831

RESUMEN

PURPOSE: Clinical practice guidelines are increasingly being used by leading organizations to promote high quality evidence-based patient care. However, the methodological quality of clinical practice guidelines developed by different organizations varies considerably. We assessed published clinical practice guidelines on the treatment of localized prostate cancer to evaluate the rigor, applicability and transparency of their recommendations. MATERIALS AND METHODS: We searched for English based clinical practice guidelines on treatment of localized prostate cancer from leading organizations in the 15-year period from 1999 to 2014. Clinical practice guidelines limited to early detection, screening, staging and/or diagnosis of prostate cancer were excluded from analysis. Four independent reviewers used the validated AGREE II instrument to assess the quality of clinical practice guidelines in 6 domains, including 1) scope and purpose, 2) stakeholder involvement, 3) rigor of development, 4) clarity of presentation, 5) applicability and 6) editorial independence. RESULTS: A total of 13 clinical practice guidelines met inclusion criteria. Overall the highest median scores were in the AGREE II domains of clarity of presentation, editorial independence, and scope and purpose. The lowest median score was for applicability (28.1%). Although the median score of editorial independence was high (85.4%), variability was also substantial (IQR 12.5-100). NICE and AUA clinical practice guidelines consistently scored well in most domains. CONCLUSIONS: Clinical practice guidelines from different organizations on treatment of localized prostate cancer are of variable quality and fall short of current standards in certain areas, especially in applicability and stakeholder involvement. Improvements in these key domains can enhance the impact and implementation of clinical practice guidelines.


Asunto(s)
Guías de Práctica Clínica como Asunto , Neoplasias de la Próstata/terapia , Humanos , Masculino
14.
Urology ; 82(2): 471-5, 2013 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-23896103

RESUMEN

OBJECTIVE: To survey urologic reconstruction experts to determine practice and surveillance patterns used after urethroplasty. METHODS: We conducted an international survey of the members of the Society of Genitourinary Reconstructive Surgeons between July 23 and October 13, 2010 through email. Participants were surveyed regarding the nomenclature used to define strictures, urethroplasty practice patterns, follow-up practice patterns, and methods used to screen for stricture recurrence. RESULTS: The response rate was 48.9% (n = 90). Urethroplasty failure was commonly defined as the need for a secondary urethral procedure (60.0%), significant narrowing on imaging (14.4%), urethral narrowing preventing passage of 16F cystoscope (12.2%) or poor uroflow, or American Urological Association Symptom Score (7.8%). Only one-third of responders followed up their patients >3 years after surgery. To screen for stricture recurrence, 85% used uroflowmetry, 56% used postvoid residual, 19% used flexible cystoscopy, and 17% used retrograde urethrography. Nearly half (48%) of the surgeons did not use validated instruments to evaluate the quality of life after urethroplasty. For those who used validated questionnaires, the ones most often used were the American Urological Association Symptom Score (41%) and Sexual Health Inventory for Men (19%). CONCLUSION: There is no consensus regarding follow-up practices after urethroplasty. Most experts define urethroplasty failure as "need for a secondary procedure," do not follow-up patients for a long-term, and do not use validated questionnaires. A standardized definition for stricture recurrence and a standardized follow-up protocol are desperately needed to allow for effective comparison of results between studies.


Asunto(s)
Pautas de la Práctica en Medicina , Estrechez Uretral/diagnóstico , Estrechez Uretral/cirugía , Adulto , Anciano , Humanos , Persona de Mediana Edad , Vigilancia de la Población , Calidad de Vida , Recurrencia , Reoperación , Encuestas y Cuestionarios , Terminología como Asunto , Insuficiencia del Tratamiento , Estrechez Uretral/fisiopatología , Catéteres Urinarios , Urodinámica
15.
Case Rep Urol ; 2013: 789039, 2013.
Artículo en Inglés | MEDLINE | ID: mdl-23533933

RESUMEN

Primary bladder cancer is the fifth most common malignancy but secondary malignancies of the bladder are rare. Distinguishing primary adenocarcinomas of the bladder from secondary adenocarcinomas is difficult and relies on immunohistochemical staining. Prostate, colorectal, breast, and lung all can produce metastatic adenocarcinomas to the bladder. Further management of the malignancy varies depending on the source, thus making proper diagnosis critical. We present only the fifth documented case of metastatic adenocarcinoma of the lung to bladder and performed a review of the literature.

16.
J Surg Educ ; 70(1): 138-43, 2013.
Artículo en Inglés | MEDLINE | ID: mdl-23337683

RESUMEN

OBJECTIVES: In selecting a medical student for a urology residency, a set of preconceived criteria as to what will predict a successful resident are generally applied. To determine what factors predict an "excellent" clinical resident and a successful in-service test taker, we analyzed 10 years of urology resident files. PARTICIPANTS AND STUDY DESIGN: Retrospective chart review of 29 urology residents at Washington University graduating from July 2000 to July 2009. Medical student applications and interview evaluations were compared with future performance as a general surgical intern and then as a urology resident, in terms of clinical performance and in-service examination scores. RESULTS: Of 29 residents, based on clinical evaluations over 4 years of urology residency, 12 were "excellent," 17 "average and needing improvement." "Excellent" residents had higher applicant rank submitted to the "match" (7.2 vs. 12.1, p = 0.04) and better letters of recommendation (3.0 vs. 2.5, 0.018). "Excellent" residents also had better evaluations as an intern (3.9 vs 2.7, p < 0.001). "Good" urology in-service examination test takers compared with "below average" test takers noted higher rank on the match list (7.8 vs 12.1, p = 0.04), better quality med school (2.6 vs 2.0; p = 0.002), higher USMLE scores (92.5 vs 86.6% tile, p = 0.02), American Board of Surgery in-training examination (ABSITE) score (58.6 vs 37.2% tile, p = 0.04), and were more likely to pass the board examination (100% vs 76.9%, p = 0.03). Residents with higher clinical evaluations were also more likely to go into fellowships (83.3% vs 16.2%, OR = 23.3) and academic careers (41.6 vs 11.1%, OR = 5.71). CONCLUSIONS: Performance as a surgery intern predicts future performance as a GU Resident. "Good" test takers as medical students and as interns continue to test well as GU residents. Early identification, intervention, and mentoring while still an intern are essential. Selection criteria we currently use to select GU residents are surprisingly predictive.


Asunto(s)
Competencia Clínica , Educación de Postgrado en Medicina/métodos , Evaluación Educacional/métodos , Internado y Residencia , Urología/educación , Distribución de Chi-Cuadrado , Humanos , Missouri , Estudios Retrospectivos , Criterios de Admisión Escolar
17.
J Urol ; 189(1): 136-40, 2013 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-23164373

RESUMEN

PURPOSE: We defined the relevant skin flora during genitourinary prosthetic surgery, evaluated the safety of chlorhexidine-alcohol for use on the male genitalia and compared chlorhexidine-alcohol to povidone-iodine in decreasing the rate of positive bacterial skin cultures at the surgical skin site before prosthetic device implantation. MATERIALS AND METHODS: In this single institution, prospective, randomized, controlled study we evaluated 100 consecutive patients undergoing initial genitourinary prosthetic implantation. Patients were randomized to a standard skin preparation with povidone-iodine or chlorhexidine-alcohol. Skin cultures were obtained from the surgical site before and after skin preparation. RESULTS: A total of 100 patients were randomized, with 50 in each arm. Pre-preparation cultures were positive in 79% of the patients. Post-preparation cultures were positive in 8% in the chlorhexidine-alcohol group compared to 32% in the povidone-iodine group (p = 0.0091). Coagulase-negative staphylococci were the most commonly isolated organisms in post-preparation cultures in the povidone-iodine group (13 of 16 patients) as opposed to propionibacterium in the chlorhexidine-alcohol group (3 of 4 patients). Clinical complications requiring additional operations or device removal occurred in 6 patients (6%) with no significant difference between the 2 groups. No urethral or genital skin complications occurred in either group. CONCLUSIONS: Chlorhexidine-alcohol was superior to povidone-iodine in eradicating skin flora at the surgical skin site before genitourinary prosthetic implantation. There does not appear to be any increased risk of urethral or genital skin irritation with the use of chlorhexidine compared to povidone-iodine. Chlorhexidine-alcohol appears to be the optimal agent for skin preparation before genitourinary prosthetic procedures.


Asunto(s)
Antiinfecciosos Locales/uso terapéutico , Clorhexidina/uso terapéutico , Etanol/uso terapéutico , Povidona Yodada/uso terapéutico , Cuidados Preoperatorios , Implantación de Prótesis , Piel/microbiología , Anciano , Humanos , Masculino , Persona de Mediana Edad , Prótesis de Pene , Estudios Prospectivos , Cabestrillo Suburetral , Esfínter Urinario Artificial
18.
Urol Oncol ; 31(5): 693-6, 2013 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-23158262

RESUMEN

OBJECTIVES: The management of patients with penile cancer who have high-risk features for micrometastasis with clinically negative inguinal lymph nodes is controversial. We describe the history of the sentinel lymph node biopsy and how it has evolved to become a useful adjunct in the management of penile cancer. MATERIALS AND METHODS: Using a PubMed search, we identified the evidence relating to the management of the inguinal lymph nodes in penile cancer between 1977 and 2010. RESULTS: The concept of the sentinel lymph node (SLN) was first described in 1977 for penile carcinoma where lymphangiograms were performed via the dorsal lymphatics of the penis to locate the primary lymphatic drainage zone of the penis situated near the saphenofemoral junction. Then, in 1992, the lymphatic mapping concept was further advanced by performing intradermal injections of blue dye to directly visualize the lymphatic channels and SLN in the treatment of melanoma. In 1994, investigators from The Netherlands pioneered the use of dynamic sentinel lymph node biopsies (DSLNB) for penile cancer by combining the use of peri-lesional blue dye injection, lymphoscintigraphy, and other future modifications of the technique to achieve low false negative biopsy rates (4.8%) as well as much lower morbidity (5.7%), compared with the 30%-50% morbidity associated with a full inguinal node dissection. CONCLUSION: DSLNB significantly decreases the morbidity associated with performing a standard or even modified inguinal lymph node dissection in patients with clinically negative inguinal lymph nodes. Performing DSLNB requires a multidisciplinary team of urologists, nuclear medicine radiologists, and pathologists working in cohesion to attain the best SLN detection rates with the lowest possible false-negative rates.


Asunto(s)
Metástasis Linfática/diagnóstico , Neoplasias del Pene/patología , Pene/patología , Biopsia del Ganglio Linfático Centinela/métodos , Humanos , Escisión del Ganglio Linfático/métodos , Masculino , Reproducibilidad de los Resultados , Sensibilidad y Especificidad
19.
J Trauma Acute Care Surg ; 72(1): 68-75; discussion 75-7, 2012 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-22310118

RESUMEN

BACKGROUND: The purpose of this study was to evaluate the contemporary practice patterns of urologists (UR) and trauma surgeons (TS) regarding controversial topics in the management of renal trauma (RT). METHODS: We conducted a national survey of all Society of Genitourinary Reconstructive Surgeons members and a random sampling of American Association for the Surgery of Trauma members between October and November 2010 via email, regarding management routines for various stages of blunt and penetrating RT. RESULTS: Response rate was 33%. In all, 21% of TS and 3% of UR (p = 0.005) do not use any tests to confirm the presence of another kidney before exploring an expanding retroperitoneal hematoma, despite lack of preoperative imaging. To confirm the presence of another kidney, UR prefer the "one-shot" intravenous pyelogram (82%), whereas TS prefer palpation (61%; p < 0.001). TS do not obtain primary renal vascular control before opening the retroperitoneal, whereas UR do (21% vs. 71%; p < 0.001). TS utilize early angiography for the control of intravascular contrast extravasation more commonly than UR (88% vs. 55%; p < 0.001). TS overutilize ureteral stenting (50% vs. 24%; p < 0.001) for isolated collecting system injuries compared with UR. Differences in practice patterns between TS and UR tend to follow differences in published guidelines. CONCLUSION: There is an apparent lack of communication and differing treatment methods for RT. That there are two camps with differing "community standards of practice" indicates that there is a desperate need for reeducation and for large-scale, multi-institutional prospective studies on RT to "standardize" management.


Asunto(s)
Riñón/lesiones , Traumatología/normas , Urología/estadística & datos numéricos , Adulto , Niño , Recolección de Datos , Humanos , Guías de Práctica Clínica como Asunto , Pautas de la Práctica en Medicina , Estados Unidos , Heridas no Penetrantes/cirugía , Heridas Penetrantes/cirugía
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