Transthoracic Ultrasound Improves Cardiac Function in Mice.

Cardiac dysfunction is a severe complication that is associated with an increased risk of mortality in multiple diseases. Cardioprotection solution that has been researched is the electrical stimulation of the vagus nerve to exert cardio protection. This method has been shown to reduce the systemic inflammatory response and maintain the immune homeostasis of the heart. However, the invasive procedure of electrode implantation poses a risk of nerve or fiber damage. Here, we propose transthoracic ultrasound stimulation (US) of the vagus nerve to alleviate cardiac dysfunction caused by lipopolysaccharide (LPS). We developed a noninvasive transthoracic US system and exposed anesthetized mice to ultrasound protocol or sham stimulation 24 h after LPS treatment. Results showed that daily heart targeting US for 4 days significantly increased left ventricular systolic function ( p = 0.01) and improved ejection fraction ( p = 0.03) and shortening fraction ( p = 0.04). Furthermore, US significantly reduced inflammation cytokines, including IL-6 ( p = 0.03) and IL- 1ß ( p = 0.04). In addition, cervical vagotomy abrogated the effect of US, suggesting the involvement of the vagus nerve's anti-inflammatory effect. Finally, the same ultrasound treatment but for a longer period (14 days) also significantly increased cardiac function in naturally aged mice. Collectively, these findings suggest the potential of transthoracic US as a possible novel noninvasive approach in the context of cardiac dysfunction with reduced systolic function and provide new targets for rehabilitation of peripheral organ function.

Functions of metal-phenolic networks and polyphenol derivatives in photo(electro)catalysis.

Phenolic compounds are ubiquitous in nature because of their unique physical and chemical properties and wide applications, which have received extensive research attention. Phenolic compounds represented by tannic acid (TA) play an important role at the nanoscale. TA with a polyphenol hydroxyl structure can chemically react with organic or inorganic materials, among which metal-phenolic networks (MPNs) formed by coordination with metal ions and polyphenol derivatives formed by interactions with organic matter, exhibit specific properties and functions, and play key roles in photo(electro)catalysis. In this paper, we first introduce the fundamental properties of TA, then summarize the factors influencing the properties of MPNs and structural transformation of polyphenol-derived materials. Subsequently, the functions of MPNs and polyphenol derivatives in photo(electro)catalysis reactions are summarized, encompassing improving interfacial charge carrier separation, accelerating surface reaction kinetics, and enhancing light absorption. Finally, this article provides a comprehensive overview of the challenges and outlook associated with MPNs. Additionally, it presents novel insights into their stability, mechanistic analysis, synthesis, and applications in photo(electro)catalysis.

Recent Advances in the Preparation and Application of Two-Dimensional Nanomaterials.

Two-dimensional nanomaterials (2D NMs), consisting of atoms or a near-atomic thickness with infinite transverse dimensions, possess unique structures, excellent physical properties, and tunable surface chemistry. They exhibit significant potential for development in the fields of sensing, renewable energy, and catalysis. This paper presents a comprehensive overview of the latest research findings on the preparation and application of 2D NMs. First, the article introduces the common synthesis methods of 2D NMs from both "top-down" and "bottom-up" perspectives, including mechanical exfoliation, ultrasonic-assisted liquid-phase exfoliation, ion intercalation, chemical vapor deposition, and hydrothermal techniques. In terms of the applications of 2D NMs, this study focuses on their potential in gas sensing, lithium-ion batteries, photodetection, electromagnetic wave absorption, photocatalysis, and electrocatalysis. Additionally, based on existing research, the article looks forward to the future development trends and possible challenges of 2D NMs. The significance of this work lies in its systematic summary of the recent advancements in the preparation methods and applications of 2D NMs.

[Regularity of meridian-acupoint reactions of foot three yin meridians in primary dysmenorrhea and secondary dysmenorrhea patients].

OBJECTIVE: To observe the meridian-acupoint reactions of foot three yin meridians in primary dysmenorrhea(PD) and secondary dysmenorrhea(SD) patients, so as to summarize the rules of meridian-acupoint reaction and acupoints selection. METHODS: Thirty-five patients with PD (PD group), 34 patients with SD (SD group) and 35 healthy subjects (healthy group) were recruited. The compression method was used to examine the lower leg segment of the foot three yin meridians. Positive reactions(palpable skin changes, including cords, nodules, depressions) and tenderness of meridians and acupoints were recorded. The visual analogue scale (VAS) was used to evaluate the tenderness severity of acupoints. RESULTS: Compared with the healthy group, the probability of positive reactions and tenderness in foot three yin meridians were higher in PD and SD groups (P<0.01,P<0.05). Compared with the PD group, the probability of positive reactions in Spleen and Liver Meridians were higher in the SD group, with higher probability of tenderness in Liver Meridian(P<0.05). The probability of positive reactions and tenderness in the Spleen Meridian of PD and SD groups was significantly higher than that in the Kidney Meridian (P<0.01), while the probability of tenderness in the Spleen Meridian of the PD group was significantly higher than that in the Liver Meridian (P<0.05). Positive reactions and tenderness were concentrated at Yinlingquan (SP9), Diji (SP8) and Sanyinjiao (SP6) of Spleen Meridian and Xiguan (LR7) and Ligou (LR5) in Liver Meridian of PD and SD groups. In comparison with the PD group, the probability of positive reactions, tenderness and VAS score of SP8 and LR5 of the SD group were higher (P<0.05, P<0.01). CONCLUSION: The positive reaction occurs most frequently in the Spleen Meridian, followed by the Liver Meridian, and least frequently in the Kidney Meridian. The acupoints with positive reaction are different between PD and SD, which suggests that the Spleen Meridian acupoints should be the main acupoints when treating the two kinds of dysmenorrhea, and acupoints should also be selected according to the meridian and acupoint examination results.

A highly sensitive TiO2-based molecularly imprinted photoelectrochemical sensor with regulation of imprinted sites by Photo-deposition.

Molecularly imprinted photoelectrochemical sensors (MIPES) have gained significant attention in the detection field due to their high selectivity and accuracy. However, their sensitivity still needs improvement. Here we developed a TiO2-based MIPES (TiO2 NRs/NiOOH/rMIP) to detect ciprofloxacin (CIP). We identified the photoactive sites of TiO2 by NiOOH photo-deposition and anchored the imprinted sites on the photoactive sites by complexation between CIP and NiOOH. By regulating the imprinted sites, the photocurrent difference before and after the addition of CIP increases and the detection sensitivity of CIP is improved. Moreover, a PN heterojunction is formed between TiO2 and NiOOH, which enables rapid transfer of photoexcited holes and electrons to different semiconductors under the built-in electric field. This leads to improved photoactivity of TiO2 and further increases the sensitivity of MIPES. Compared with sensors prepared by the traditional electro-polymerization CIP and Molecularly imprinted polymers (TiO2 NRs/NiOOH/eMIP), TiO2 NRs/NiOOH/rMIP as constructed in this work displays higher sensitivity, wider linear detection range, and lower limit of detection (LOD). Additionally, TiO2 NRs/NiOOH/rMIP shows good selectivity, stability, and recovery rate, and has a promising application prospect in the actual detection of antibiotics.

Novel trifunctional electrocatalyst of nickel foam supported Co2P/NiMoO4 heterostructures for overall water splitting and urea oxidation.

The process of electrocatalytic water splitting for hydrogen generation is significantly limited by sluggish kinetics of the anodic oxygen evolution reaction (OER). The efficiency of H2 electrocatalytic generation can be improved by reducing the anode potential or substituting urea oxidation reaction (UOR) for oxygen evolution process. Here, we report a robust catalyst based on Co2P/NiMoO4 heterojunction arrays supported on nickel foam (NF) for water splitting and urea oxidation. In the hydrogen evolution reaction in alkaline media, the optimized catalyst Co2P/NiMoO4/NF displayed a lower overpotential (169 mV) at a large current density (150 mA cm-2) compared to 20 wt% Pt/C/NF (295 mV@150 mA cm-2). In the OER and UOR, the potentials were as low as 1.45 and 1.34 V. These values surpass (for OER), or compare favorably to (for UOR), the most advanced commercial catalyst RuO2/NF (at 10 mA cm-2). This outstanding performance was attributed to the addition of Co2P, which has a significant effect on the chemical environment and electron structure of NiMoO4, while increasing the number of active sites and promoting charge transfer across the Co2P/NiMoO4 interface. This work proposes a high-performance and cost-effective electrocatalyst for water splitting and urea oxidation.

Highly stable lithium sulfur batteries enhanced by flocculation and solidification of soluble polysulfides in routine ether electrolyte.

Lithium-sulfur batteries (LSBs) are among the most promising next-generation high energy density energy-storage systems. However, practical application has been hindered by fundamental problems, especially shuttling by the higher-order polysulfides (PSs) and slow redox kinetics. Herein, a novel electrolyte-based strategy is proposed by adding an ultrasmall amount of the low-cost and commercially available cationic antistatic agent octadecyl dimethyl hydroxyethyl quaternary ammonium nitrate (SN) into a routine ether electrolyte. Due to the strong cation-anion interaction and bridge-bonding with SN, rapid flocculation of the soluble polysulfide intermediates into solid-state polysulfide-SN sediments is found, which significantly inhibited the adverse shuttling effect. Moreover, a catalytic effect was also demonstrated for conversion of the polysulfide-SN intermediates, which enhanced the redox kinetics of Li-S batteries. Encouragingly, for cells with only 0.1 % added SN, an initial specific capacity of 783.6 mAh/g and a retained specific capacity of 565.7 mAh/g were found at 2C after 200 cycles, which corresponded to an ultralow capacity decay rate of only 0.014 % per cycle. This work may provide a simple and promising regulation strategy for preparing highly stable Li-S batteries.

Al-Incorporated Cobalt-Layered Double Hydroxides for Enhanced Oxygen Evolution through Morphology and Electronic Structure Regulation.

Layered double hydroxides (LDHs) are promising electrocatalytic materials for the oxygen evolution reaction (OER) due to their tunable composition and low cost. Here, we construct ultrathin Al-incorporated Co LDH nanosheets on carbon cloth (CC) by a facile hydrothermal strategy. Compared to Co LDH/CC, the optimized Co2Al1 LDH/CC displays significantly improved OER performance, characterized by low overpotentials of only 171 and 200 mV to reach current densities of 10 mA cm-2 in alkaline and neutral media, respectively, as well as good stability over an extended period. The introduced Al3+ and CC support play a synergistic role in steering the morphology of Co2Al1 LDH/CC while also increasing the electrochemical active sites. X-ray absorption fine spectra (XAFS) analyses uncover the critical role of Al in regulating the coordination environment of Co atoms, with evidence affording highly active Co oxidation states. Moreover, density functional theory (DFT) calculations confirmed that the Al3+ incorporated into Co LDH/CC can efficaciously modulate the electronic density of states of the d-band center of Co atoms, optimize the Gibbs free energies of intermediates toward OER, and thus accelerate the O2 evolution rate.

Structural Engineering of BiVO4 /CoFe MOF Heterostructures Boosting Charge Transfer for Efficient Photoelectrochemical Water Splitting.

Boosting charge separation and transfer of photoanodes is crucial for providing high viability of photoelectrochemical hydrogen (H2 ) generation. Here, a structural engineering strategy is designed and synthesized for uniformly coating an ultrathin CoFe bimetal-organic framework (CoFe MOF) layer over a BiVO4 photoanode for boosted charge separation and transfer. The photocurrent density of the optimized BiVO4 /CoFe MOF(NA) photoanode reaches a value of 3.92 mA cm-2 at 1.23 V versus reversible hydrogen electrode (RHE), up to 6.03 times that of pristine BiVO4 , due to the greatly increased efficiency of charge transfer and separation. In addition, this photoanode records one onset potential that is considerably shifted negatively when compared to BiVO4 . Transient absorption spectroscopy reveals that the CoFe MOF(NA) prolongs charge recombination lifetime by blocking the hole-transfer pathway from the BiVO4 to its surface trap states. This work sheds light on boosting charge separation and transfer through structural engineering to enhance the photocurrent of photoanodes for solar H2 production.

Highly Selective Colorimetric Detection of Cu2+ Using EDTA-Complexed Chlorophyll-Copper/ZnO Nanorods with Cavities Specific to Cu2+ as a Light-Activated Nanozyme.

In this study, chlorophyll-copper (ChlCu)-modified ZnO nanorods (ChlCu/ZnO) were prepared, and then sodium ethylenediamine tetraacetate (EDTA) was used to remove part of Cu2+ in ChlCu, leaving cavities with specific adsorption activity for Cu2+ in E-ChlCu/ZnO. Appropriate EDTA treatment improved the photoactivity of ChlCu/ZnO and the adsorption selectivity to Cu2+. However, excessive EDTA treatment might lead to the collapse of the ChlCu structure, resulting in a decrease in photoactivity. The E-ChlCu/ZnO sample with 8 h of ChlCu treatment and 2 h of EDTA treatment showed optimal photoactivity. The as-prepared E-ChlCu/ZnO exhibited activity as a light-activated nanozyme, which could oxidize 3,3',5,5'-tetramethylbenzidine (TMB) to blue under illumination, but when Cu2+ was present in the solution, this colorimetric reaction was inhibited; therefore, E-ChlCu/ZnO could be used for colorimetric detection of Cu2+. Because of the existence of specific cavities, E-ChlCu/ZnO showed excellent detection selectivity, a wide linear detection range (0-1 and 1-15 µM), and a low detection limit (0.024 µM) in the colorimetric detection of Cu2+.

Constructing Direct Z-Scheme Heterostructure by Enwrapping ZnIn2 S4 on CdS Hollow Cube for Efficient Photocatalytic H2 Generation.

Rational design hybrid nanostructure photocatalysts with efficient charge separation and transfer, and good solar light harvesting ability have critical significance for achieving high solar-to-chemical conversion efficiency. Here a highly active and stable composite photocatalyst is reported by integrating ultrathin ZnIn2 S4 nanosheets on surface of hollow CdS cube to form the cube-in-cube structure. Experimental results combined with density functional theory calculations confirm that the Z-scheme ZnIn2 S4 /CdS heterojunction is formed, which highly boosts the charge separation and transfer under the local-electric-field at semiconductor/semiconductor interface, and thus prolongs their lifetimes. Moreover, such a structure affords the highly enhanced light-harvesting property. The optimized ZnIn2 S4 /CdS nanohybrids exhibit superior H2 generation rate under visible-light irradiation (λ ≥ 420 nm) with excellent photochemical stability during 20 h continuous operation.

Ultrasound Stimulation of Prefrontal Cortex Improves Lipopolysaccharide-Induced Depressive-Like Behaviors in Mice.

Increasing evidence indicates that inflammatory responses may influence brain neurochemical pathways, inducing depressive-like behaviors. Ultrasound stimulation (US) is a promising non-invasive treatment for neuropsychiatric diseases. We investigated whether US can suppress inflammation and improve depressive-like behaviors. Mice were intraperitoneally injected with lipopolysaccharide to induce depressive-like behaviors. Ultrasound wave was delivered into the prefrontal cortex (PFC) for 30 min. Depressive- and anxiety-like behaviors were evaluated through the forced swimming test (FST), tail suspension test (TST), and elevated plus maze (EPM). Biochemical analyses were performed to assess the expression of inflammatory cytokines in the PFC and serum. The results indicated that US of the PFC significantly improved depressive-like behaviors in the TST (p < 0.05) and FST (p < 0.05). Anxiety-like behaviors also improved in the EPM (p < 0.05). Furthermore, the lipopolysaccharide-mediated upregulation of IL-6, IL-1ß, and TNF-α in the PFC was significantly reduced (p < 0.05) by US. In addition, no tissue damage was observed. Overall, US of PFC can effectively improve lipopolysaccharide-induced depressive-like behaviors, possibly through the downregulation of inflammatory cytokines in the PFC. US may be a safe and promising tool for improvement of depression.

Non-Cavitation Targeted Microbubble-Mediated Single-Cell Sonoporation.

Sonoporation employs ultrasound accompanied by microbubble (MB) cavitation to induce the reversible disruption of cell membranes and has been exploited as a promising intracellular macromolecular delivery strategy. Due to the damage to cells resulting from strong cavitation, it is difficult to balance efficient delivery and high survival rates. In this paper, a traveling surface acoustic wave (TSAW) device, consisting of a TSAW chip and a polydimethylsiloxane (PDMS) channel, was designed to explore single-cell sonoporation using targeted microbubbles (TMBs) in a non-cavitation regime. A TSAW was applied to precisely manipulate the movement of the TMBs attached to MDA-MB-231 cells, leading to sonoporation at a single-cell level. The impact of input voltage and the number of TMBs on cell sonoporation was investigated. In addition, the physical mechanisms of bubble cavitation or the acoustic radiation force (ARF) for cell sonoporation were analyzed. The TMBs excited by an ARF directly propelled cell membrane deformation, leading to reversible perforation in the cell membrane. When two TMBs adhered to the cell surface and the input voltage was 350 mVpp, the cell sonoporation efficiency went up to 83%.

Enhanced triethylamine-sensing properties of hierarchical molybdenum trioxide nanostructures derived by oxidizing molybdenum disulfide nanosheets.

A 3D α-MoO3 nanostructure for high-performance triethylamine (TEA) detection was synthesized via the facial oxidation of MoS2 nanoflowers (NFs) obtained by a hydrothermal process. The influence of the time of hydrothermal process in growing MoS2 on the morphologies of the final MoO3 obtained after calcination was investigated. As-obtained MoO3 and their precursors were systematically characterized by various techniques, such as X-ray diffraction, Raman, scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy, and N2 adsorption-desorption isotherms. Results showed that MoO3 with a hierarchical layered nanostructure was successfully obtained. After hydrothermal treatment of the MoS2 precursor for 20 h, the typical MoO3-based sensor (called M20) exhibited a high response of 2.42 at a very low TEA concentration of only 0.1 ppm at 240 °C. The M20 sensor response to 50 ppm TEA was as high as 125 with a fast response/recovery time of 14/22 s. Moreover, the sensor had a high stability and reproducibility as well as a high selectivity against other interfering VOCs or gases. Due to the tendency of TEA to adsorb to active oxygen sites of MoO3, the enhanced sensing properties of MoO3 can be ascribed to the remarkable hierarchical structure and large surface area. MoO3 obtained after calcination of hydrothermally grown MoS2 is thus a promising sensing material for enhanced TEA gas detection.

Acoustofluidic dynamic interfacial tensiometry.

The interfacial tension (IFT) of fluids plays an essential role in industrial, biomedical, and synthetic chemistry applications; however, measuring IFT at ultralow volumes is challenging. Here, we report a novel method for sessile drop tensiometry using surface acoustic waves (SAWs). The IFT of the fluids was determined by acquiring the silhouette of an axisymmetric sessile drop and applying iterative fitting using Taylor's deformation equation. Owing to physiochemical differences, upon interacting with acoustic waves, each microfluid has a different streaming velocity. This streaming velocity dictates any subsequent changes in droplet shape (i.e., height and width). We demonstrate the effectiveness of the proposed SAW-based tensiometry technique using blood plasma to screen for high leptin levels. The proposed device can measure the IFT of microscale liquid volumes (up to 1 µL) with an error margin of only ±5% (at 25 °C), which deviates from previous reported results. As such, this method provides pathologists with a solution for the pre-diagnosis of various blood-related diseases.

Neuroprotective Effect of Ultrasound Neuromodulation on Kainic Acid- Induced Epilepsy in Mice.

Preliminary evidence suggests that low-intensity pulsed ultrasound (LIPUS) has neuroprotective effects on ischemic stroke, depression, and other conditions leading to neuronal cell death (e.g., Parkinson's disease). The purpose of this study was to investigate the neuroprotective effects of LIPUS in epileptic mice. Mice were made epileptic through kainic acid (KA) administration and then stimulated with LIPUS. The neuroprotective effect of ultrasound was evaluated by observing the latency, anxiety-like behavior, and levels of proteins related to inflammation, apoptosis, or signaling pathways. The safety of LIPUS was assessed by hematoxylin and eosin (H&E) and Nissl stainings. LIPUS prolonged the latency (Sham: 6.00 ± 0.26 days; 1-kHz pulse repetition frequency (PRF): 7.00 ± 0.31 days), improved the anxiety-like behavior, and inhibited the expression of inflammatory factors and apoptosis-related proteins. In addition, H&E and Nissl staining results confirmed that LIPUS did not damage the brain. These findings suggest that LIPUS has neuroprotective effects in mice with KA-induced epilepsy. LIPUS may offer a new therapeutic approach to epilepsy.

High temperature induced S vacancies in natural molybdenite for robust electrocatalytic nitrogen reduction.

Defect engineering is an important strategy to regulate electronic structure of electrocatalysts for electrochemical N2 fixation, aiming at improving the electron state density and enhancing the adsorption and activation of inert N2. In this paper, a high-temperature strategy to anneal the natural molybdenite under Ar atmosphere was developed, and the as-obtained molybdenite with S vacancies boosted a high activity for N2 reduction reaction. In 0.1 M HCl, the catalyst annealed at 800 °C exhibits a high Faradic efficiency of 17.9% and a NH3 yield of 23.38 µg h-1 mg-1cat. at -0.35 V versus reversible hydrogen electrode, two times higher than that of the pristine molybdenite. The facile one-step annealing method introduces the defects (e.g., S vacancies) in the surface of the natural molybdenite particles to prepare catalysts for generating ammonia by reducing nitrogen at room temperature under ordinary pressure, promoting the development of low-carbon economic prospect.

Microwave-assisted synthesis of hierarchically porous Co3O4/rGO nanocomposite for low-temperature acetone detection.

Acetone sensors with high response and excellent selectivity are of enormous demand for monitoring the diabetes. This paper has reported a novel porous 3D hierarchical Co3O4/rGO nanocomposite synthesized by a microwave-assisted method, by which Co3O4 nanoparticles are rapidly and uniformly anchored on rGO nanosheets. The phase composition, surface morphology of the Co3O4/rGO composites and the effect of rGO on their acetone-sensing performance were systematically investigated. The results show that the sample with an optimized content of rGO (Co3O4/rGO-1) achieves the highest stability and response to acetone (0.5 ~ 200 ppm) at a relatively low temperature (~160 °C). Also, the Co3O4/rGO-1 exhibits a high acetone-sensing selectivity against the gases (or vapors) of H2S, H2, CH4, HCHO, CH3OH, C3H8O and C2H5OH. The enhanced acetone-sensing performance of the Co3O4/rGO composite can be attributed to the Co3O4/rGO p-p heterojunction and the Co3+-C coupling effect between Co3O4 and rGO, improving transport of carriers. In addition, the unique 3D hierarchically porous structure and large surface areas are favorable to adsorption and desorption of gas molecules. This facile microwave-assisted method provides a charming strategy to develop smart rGO-based nanomaterials for real-time detection of harmful gases and rapid medical diagnosis.

Transcranial Ultrasound Stimulation of the Anterior Cingulate Cortex Reduces Neuropathic Pain in Mice.

Focused ultrasound (FUS) is a potential tool for treating chronic pain by modulating the central nervous system. Herein, we aimed to determine whether transcranial FUS stimulation of the anterior cingulate cortex (ACC) effectively improved chronic pain in the chronic compress injury mice model at different stages of neuropathic pain. The mechanical threshold of pain was recorded in the nociceptive tests. We found FUS stimulation elevated the mechanical threshold of pain in both short-term (p < 0.01) and long-term (p < 0.05) experiments. Furthermore, we determined protein expression differences in ACC between the control group, the intervention group, and the Sham group to analyze the underlying mechanism of FUS stimulation in improving neuropathic pain. Additionally, the results showed FUS stimulation led to alterations in differential proteins in long-term experiments, including cellular processes, cellular signaling, and information storage and processing. Our findings indicate FUS may effectively alleviate mechanical neuropathic pain via the ACC's stimulation, especially in the chronic state.

Microsized Red Luminescent MgAl2O4:Mn4+ Single-Crystal Phosphor Grown in Molten Salt for White LEDs.

A single-crystalline defect-less phosphor is desired for efficient luminescence of the therein doped optical activators. In this paper, microsized MgAl2O4:Mn4+ single-crystal phosphors with bright red luminescence were grown in molten LiCl salt at 950 °C, for application in blue LED pumped white lighting. By comparing the phosphor formation from various Mg2+- and Al3+-bearing sources, both the template-formation and the dissolution-diffusion processes were evidenced to account for the formation of the microsized MgAl2O4:Mn4+ crystallites. Using nano γ-Al2O3 as the Al3+-bearing precursor, the uniform MgAl2O4:Mn4+ microcrystallites with a {111} planes-exposed tetragonal bipyramid morphology were obtained. The photoluminescence property was studied at various temperatures, and Mg ↔ Al anti-site disorder induced luminescence broadening was discussed. The Mn4+ 2Eg → 4A2g transition in MgAl2O4 shows a quite short luminescence wavelength peaking at 651 nm and ultrabroadband emission extending to 850 nm. The luminescence is relatively robust against thermal effect with relatively high thermal quenching temperature of 400 K and activation energy of 0.23 eV. Employing the red-emitting MgAl2O4:Mn4+ crystallites, blue LED pumped white lighting prototypes were fabricated which simulate the solar-like spectrum and show neutral to warm white.