Investigating the interplay of chronotypes, neuropsychiatric dimensions, demographic and clinical characteristics and disability in migraine patients: A cross-sectional assessment.

The study investigated associations between chronotypes (Morning [M], Neither [N], Evening [E]), sociodemographic characteristics, body mass index (BMI), smoking habits, years with migraines, sleep quality (PSQI), anxiety (HADS-A), depression (HADS-D), migraine disability (MIDAS), headache frequency, and pain intensity (VAS) in 80 individuals with migraine. Significant age differences emerged (p < 0.001), with M-types being the oldest. BMI also varied, with M-types presenting the highest median BMI (p = 0.005). While migraine duration and headache frequency showed no significant variance, sleep quality did, with E-types reporting the poorest sleep (p = 0.030). Anxiety and depression were significantly worse in E-types (HADS-A: p = 0.002; HADS-D: p = 0.010). Differences in MIDAS levels were notable (p = 0.038); however, differences in MIDAS scores were not significant (p = 0.115). Pain intensity varied, with E-types experiencing the most severe pain (p = 0.009). Post-hoc analysis showed higher MIDAS scores in E-types compared to N-types (χ2 = 6.56, p = 0.038, ε2 = 0.0831). The findings highlight the need for thorough patient evaluations and tailored care, considering the complex interplay of factors affecting migraine severity, particularly among different chronotypes.

Thalamic nuclei volume differences in schizophrenia patients and healthy controls using probabilistic mapping: A comparative analysis.

AIM: We aimed to investigate potential discrepancies in the volume of thalamic nuclei between individuals with schizophrenia and healthy controls. METHODS: The imaging data for this study were obtained from the MCICShare data repository within SchizConnect. We employed probabilistic mapping technique developed by Iglesias et al. (2018). The analytical component entailed volumetric segmentation of the thalamus using the FreeSurfer image analysis suite. Our analysis focused on evaluating the differences in the volumes of various thalamic nuclei groups within the thalami, specifically the anterior, intralaminar, medial, posterior, lateral, and ventral groups in both the right and left thalami, between schizophrenia patients and healthy controls. We employed MANCOVA to analyse these dependent variables (volumes of 12 distinct thalamic nuclei groups), with diagnosis (SCZ vs. HCs) as the main explanatory variable, while controlling for covariates such as eTIV and age. RESULTS: The assumptions of MANCOVA, including the homogeneity of covariance matrices, were met. Specific univariate tests for the right thalamus revealed significant differences in the medial (F[1, 200] = 26.360, p < 0.001), and the ventral groups (F[1, 200] = 4.793, p = 0.030). For the left thalamus, the medial (F[1, 200] = 22.527, p < 0.001); posterior (F[1, 200] = 8.227, p = 0.005), lateral (F[1, 200] = 7.004, p = 0.009), and ventral groups (F[1, 200] = 9.309, p = 0.003) showed significant differences. CONCLUSION: These findings suggest that particular thalamic nuclei groups in both the right and left thalami may be most affected in schizophrenia, with more pronounced differences observed in the left thalamic nuclei. FUNDINGS: The authors received no financial support for the research.

The Relationship Between Chronotype and Impulsivity, Attention-Deficit Disorder, Internet, Social Media, and Smartphone Addiction.

Background: The aim of our study is to investigate the relationship between chronotypes and impulsivity, attention-deficit disorder and smartphone, social media, and internet addiction in a sample of university students. Method: The study was conducted at our university from May to July 2021. A total of 255 subjects were recruited in the study among the students from the medical faculty and the faculty of health sciences (departments of nutrition and dietetics, nursing, and physiotherapy and rehabilitation) of our university who received face-to-face education in 2020-2021. Sociodemographic data form, the Adult Attention-Deficit/Hyperactivity Disorder Self-Report Scale, Morningness-Eveningness Questionnaire, Barratt Impulsiveness Scale-11 Short Form, Young's Internet Addiction Scale, Social Media Addiction Scale-Adult Form, and Smartphone Addiction Scale-Short Version were administered by the study investigators through face-to-face interviews. Results: Among the students, the intermediate type was most common (n = 157) and the evening type was least common (n = 44). The chronotypes differed in terms of the time spent daily on smartphone and internet (P = .001 and P < .001). The evening types showed significantly higher mean scores on the Adult Attention-Deficit/Hyperactivity Disorder Self-Report Scale, Morningness-Eveningness Questionnaire, Barratt Impulsiveness Scale-11 Short Form, Young's Internet Addiction Scale, Social Media Addiction Scale-Adult Form, and Smartphone Addiction Scale-Short Version when compared with other chronotypes. Female and male students showed comparable scores on all scales. Chronotypes were not different between genders. Conclusions: The results of our study showed a greater frequency of smartphone, internet, and social media addiction among the evening types than in the other chronotypes. Greater impulsivity and attention problems as observed in the evening types may be predisposing these individuals to develop addiction to smartphone, internet, and social media.

Could Modafinil Be an Option in the Treatment of Sexual Dysfunctions Due to Antidepressant Use in Women? Two Case Reports. / Kadinlarda Antidepresan Kullanimina Bagli Gelisen Cinsel Islev Bozukluklarinin Tedavisinde Modafinil Bir Seçenek Olabilir mi? Iki Olgu Sunumu.

Antidepressants are known to cause sexual dysfunctions. Sexual side effects due to antidepressants negatively affect compliance with treatment. Modafinil is a stimulant drug used for narcolepsy and some other sleep disorders. It is also used in treatment of resistant depression, chronic fatigue syndrome, attention deficit hyperactivity disorder, and cocaine addiction syndrome. In this article, two female patients whose depressive complaints improved with antidepressant treatment, but who applied to the psychiatry outpatient clinic with complaints of sexual dysfunction and daytime sleepiness, will be presented. Both patients had loss of sexual desire, arousal and orgasm difficulties. The sexual histories obtained from the patients suggested that there was no sexual dysfunction in the period before they started using antidepressants. Both patients stated that they did not want to change the current antidepressant treatment. Modafinil 100 mg/day was prescribed to the patients for daytime sleepiness. One month after the initiation of modafinil 100 mg/day in the 39-yearold patient, there was a marked decrease in the complaints of loss of sexual desire, decreased sexual arousal and orgasm difficulties. In the other patient, 43 years old, a slight improvement in sexual functions was observed after the initiation of modafinil. In this case, after the modafinil dose was increased to 200 mg/day, there was a significant improvement in sexual dysfunctions. In both cases, the improvement in sexual dysfunctions and possible mechanisms as a result of the addition of modafinil to the treatment will be discussed. Keywords: Antidepressant, woman, sexual dysfunction, modafinil.

The relationship of chronotypes with food addiction, impulsivity, and attention deficit hyperactivity disorder symptoms in a sample of undergraduate university students.

The primary aim of the current study was to examine the frequency of food addiction in a group of university students and whether it differed among chronotypes. The second aim was to investigate the relationship of chronotypes with impulsivity, poor sleep quality and attention deficit/ hyperactivity disorder (ADHD) symptoms and to evaluate how this relationship affects food addiction. 328 university students were included in the study. Adult Attention Deficit/Hyperactivity Disorder Self-Report Scale (ASRS), Morningness-Eveningness Questionnaire (MEQ), Barratt Impulsiveness Scale-11 Short Form (BIS-11-SF), Yale Food Addiction Scale (YFAS) and Pittsburgh Sleep Quality Index (PSQI) were administered. Evening types scored significantly higher on ASRS and BIS-11 SF (p < .001, p < .001 respectively). Based on YFAS scores, 12.5% (n = 41) of the participants met the criteria for food addiction. The number of participants fulfilling the criteria for food addiction was higher among the evening types compared to intermediate and morning types (p = .006, p = .004, respectively). The mean ASRS and BIS-11 SF scores of the students who met the criteria for food addiction were significantly greater than those who did not (p < .001, p < .001, respectively). 63.4% (n = 26) of the students meeting the criteria for food addiction scored 6 or higher on PSQI versus 32.0% (n = 92) of the students who did not (p < .001). Mediation analysis showed that the direct effect of MEQ scores on food addiction was not significant (ß = -0.009, p = .723). However, lower MEQ scores had an indirect effect on food addiction through higher ASRS scores (ß = -0.027; p < .05 bias corrected and accelerated 95% CI -0.052 to -0.011). The results of the present study suggest that higher prevalence of food addiction among evening types seems to be related to higher occurrence of ADHD symptoms in these chronotypes. Further population-based studies with a larger sample size are needed to confirm our findings.

Treatment of Depression with Vortioxetine in a Patient with Comorbid Major Depressive Disorder and Restless Legs Syndrome: A Case Report.

Many case reports have shown that the use of antidepressants can lead to restless legs syndrome (RLS). Vortioxetine is a new generation antidepressant with a multimodal mechanism of action on serotonin receptors. In this case report, partial improvement in RLS symptoms after treatment with vortioxetine in a patient with a co-diagnosis of major depressive disorder and restless legs syndrome will be discussed. A 59-year-old female patient was admitted to the psychiatry outpatient clinic due to depressive complaints for three months. In the control examination, it was learned that the patient had complaints of RLS that had been going on for about 20 years. RLS symptoms were increased with selective serotonin reuptake inhibitors (SSRI) used by the patient. In the follow-up examination in the first month after vortioxetine treatment, clinically significant improvement was observed in the patient's depressive complaints, while a partial reduction in RLS symptoms was observed.

Restless Legs Syndrome Due to the Use of Trazodone: A Case Report. / Trazodon Kullanimina Bagli Huzursuz Bacak Sendromu: Bir Olgu Sunumu.

Many case reports have demonstrated that using antidepressants and especially the selective serotonin reuptake inhibitors (SSRIs), and the noradrenergic and specific serotonergic antidepresants mirtazapine and mianserin can lead to restless legs syndrome (RLS). However, there are disagreements in the results of the limited number of investigations on the relationship of RLS with antidepressants. Trazodone is a frequently used antidepressant with complex agonistic/antagonistic effects on the serotonergic system and moderate blockage on the histamine receptor. This report dicusses the case of a 39-year old female patient who developed RLS after using trazodone (100mg/day) prescribed by her pscyhiatrist for treating her insomnia complaints. We have learned from the patient's statement that she felt burning, tingling and restlessness in her legs, that started from the first night of the treatment and caused an urge to move her legs. The effects were attributed to trazodone and the treatment was discontinued. The patient reported at her control examination the disappearance of RLS symptoms one day after discontinuing trazodone use and the complete improvement of her insomnia complaints.

Restless Legs Syndrome: Associated with Major Depressive Disorder and Anxiety Disorder But Not with Antidepressant Use.

Background: The current study primarily aimed to investigate whether the prevalence of restless legs syndrome differs in patients diagnosed with major depressive disorder or anxiety disorder without antidepressant use compared to control group. Secondly, the study sought to examine whether there was a difference in restless legs syndrome prevalence among patients on antidepressant treatment compared to control subjects. Methods: Five hundred patients who were diagnosed with anxiety disorder or major depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)-5 criteria without a history of antidepressant treatment were included in the study (group 1). Group 2 consisted of 500 patients diagnosed with anxiety disorder or major depressive disorder and on antidepressant treatment who were identified as being in complete or partial remission via psychiatric interview based on DSM-5 criteria. Five hundred age- and sex-matched subjects without any mental illness were included in control group (Group 3). Results: Among all participants, restless legs syndrome was diagnosed in 101 (6.73%) individuals. There were no significant differences in age, gender, smoking status, marital status, and education level between those with or without a diagnosis of restless legs syndrome (P = .209, P = .519, P = .227, P = .508, P = .676, respectively). Restless legs syndrome was diagnosed in 65/500 (13.0%) group 1 patients, 16/500 (3.2%) group 2 patients, and 20/500 (4.0%) control subjects, with a significant difference among the groups (P < .001). The prevalence of RLS diagnosis did not significantly differ among patients receiving different antidepressant drugs (P = .965). Conclusion: Antidepressant use was not found to be a risk factor for restless legs syndrome. Our study presents important data on the close association of anxiety disorder, especially major depressive disorder with restless legs syndrome.