Hepatocyte infusions improve the results of liver transplantation in rats.

BACKGROUND/AIMS: The results of liver transplantation were influenced by miscellaneous factors. The aim was the notion that hepatocyte infusions might improve results of liver transplantation in rats. METHODOLOGY: Survival, serum analytes, FasL production, and histologic degree of rejection of transplanted rats pretreated with hepatocyte infusions (Hepatocyte) was compared to that of rats pretreated with either bone marrow cell infusions (Marrow) or saline infusions (Control). RESULTS: Hepatocyte rats had longer median survivals, less biochemical evidence of liver damage, more albumin production, a lower degree of histologic rejection, and increased FasL production than did either Marrow or Control rats (p < 0.05 for each analysis), which did not differ from one another (p > 0.05 for each analysis). CONCLUSIONS: Hepatocyte infusions improve the results of liver transplantation in rats.

Hemodialysis-induced hyperglycemia after liver transplantation.

BACKGROUND/AIMS: One might hypothesize that hemodialysis, by cleansing the blood of metabolic waste, might elevate the patient's sensitivity to insulin. The results of this study show that hypothesis is untrue in the case of liver transplant patients. METHODOLOGY: Glucose levels of five liver transplant patients, whom underwent 24 hemodialysis sessions in total, were compared with that of five non-liver transplantation patients, whom had undergon 21 hemodyalisis sessions in total. RESULTS: For liver transplant patients, Glucose levels at two, four, six and eight hours but the ten hours were significantly higher compared with that at the onset of the sessions (p<0.05). In contrast, this phenomenon could not be found in non-liver transplant patients (p>0.05). CONCLUSIONS: The patients who have undergone liver transplantation are more likely to experience hyperglycemia during hemodyalisis than patients who have not undergone liver transplantation.