Epidemiological characteristics and risk factors of syphilis among blood donors in Huzhou.

OBJECTIVE: To investigate the epidemiological characteristics and risk factors for syphilis in Huzhou City, and to provide data to support the design of more effective health counselling and screening measures for blood donors. METHODS: A retrospective study was conducted to analyse the demographic characteristics and seropositivity of syphilis among blood donors from 2019 to 2021. The differences in the serological status of syphilis among different populations under different demographic factors were compared, and conditional logistic regression analysis was used to identify the risk factors for syphilis. RESULTS: The seropositivity rate of syphilis among blood donors in Huzhou City was 133/100,000, which decreased year by year. There were significant differences in the syphilis seropositivity rate among different groups in terms of age, education level, occupation, household registration, marital status and blood donation history (P < 0.05). The multivariate logistic regression model showed that all six factors, including age, education level, occupation, household registration, marital status and blood donation history, had significant effects on syphilis infection (P < 0.01), with OR values and 95% CIs of 2. 387 (1.381-4.127), 3.607 (1.609-8.086), 2.784 (1.657-4.679), 5.074 (1.865-13.804), 11.177 (3.481-35.888), and 11.244 (3.940-32.091), respectively. CONCLUSION: There is room for improvement in pre-donation health counselling and screening of high-risk populations. Timely monitoring and updating of demographic data for specific high-risk populations is essential.

Blood inventory early warning system: the application in inventory management / 中国输血杂志

【Objective】 To conduct accurate analysis of blood inventory, so as to provide basis for taking targeted measures. 【Methods】 Taking the suspended red blood cells(RBCs) as an example, mathematical formulas were set by online Excel table, and the inventory of each blood group of RBCs in a certain day can be predicted accurately by inputting daily inventory and units distributed, and estimated daily units collected.Preventive measures such as enhancing recruitment or limiting collection could be taken as soon as possible to keep the blood inventory at a reasonable level. 【Results】 Blood inventory had been moderate during the six months of practice, and neither blood shortage nor collected blood expiring occurred. 【Conclusion】 The early warning system based on the online form, which is highly practical and easy to operate, is suitable for inventory management of blood components.

Application of Tencent collectiontable in satisfaction survey of blood donors / 中国输血杂志

【Objective】 To explore a new approach to realize the informatization of blood donor satisfaction survey without cost input. 【Methods】 A new collection table i. e. satisfaction questionnaire, was created using Tencent Document, and the QuickMark(QR) code corresponding to the collection table was scanned by the respondents through WeChat to fill in the items on line after authorized login. Classification, summary and statistics of the survey results was conducted through background formula. 【Results】 The satisfaction survey in December 2020 showed that the satisfaction rate of blood donors in that month was 98.16%, with service attitude, appearance and blood donation publicity in top 3 rated at 98.26%(4 859/4 945), 98.14%(4 853/4 945) and 90.08%(4 850/4 945), respectively, and blood donation environment the lowest, rated at 97.82%(4 837/4 945). The survey does not involve personal privacy other than WeChat network name, and the reliability and security of the results are relatively high. 【Conclusion】 This online approach using Tencent Document is cost free, applicable and convenient, therefore worthes popularization.

Analysis of glycosylated hemoglobin in apheresis platelet donors / 中国输血杂志

【Objective】 To investigate the level of glycosylated hemoglobin (HbA1c) in apheresis platelet donors, so as to further ensure the safety of apheresis platelet donors and provide guidance for the recruitment strategy. 【Methods】 Apheresis platelet donors from July 2018 to December 2020 were selected and venous blood was drawn. The glycosylated hemoglobin detection was conducted for donors who had never did this before or did this 3 months ago, and glycosylated hemoglobin >6.0% was regarded as abnormal. 【Results】 A total of 986 blood donors were detected, among which 32 donors with abnormal glycosylated hemoglobin were found, rated at 3.25%. With the increase of age and BMI(height and body mass index), the proportion of abnormal glycosylated hemoglobin increased, but the 51~60 age group and BMI > 28.0 group were not the highest, which may be related to the source of samples.The rate of abnormal glycosylated hemoglobin was highest in 40~50 years old group (5.43%, 15 / 276) and BMI ranged of 24.0~27.9 (4.04%, 9 / 223), and lowest (0.85%, 1 / 118) in 18~25 years old group and BMI >28.0(none). 【Conclusion】 The abnormal glycosylated hemoglobin is closely related to age and BMI. Therefore, we should give priority to young and underweight donors when recruiting blood donors, which can improve efficiency and maximize the safety of blood donors.

Application of continuous renal replacement therapy in coronavirus disease 2019 / 中华危重病急救医学

Continuous renal replacement therapy (CRRT) has become an effective multiple organ support therapy instead of single renal replacement as initially expected, and it is widely used in intensive care unit (ICU). After the outbreak of coronavirus disease 2019 (COVID-19), a series of expert recommendation or consensus have been developed to diagnose and treat the disease, including CRRT in acute kidney injury (AKI) and hyper inflammatory response. However, CRRT in COVID-19 is extraordinarily different from regular one due to different pathophysiology and infectious clinical scenarios. Accordingly, the paper aims to elaborate the similarities and differences between CRRT in COVID-19 and routine treatment in terms of safety and accessibility, indications and timing, clinical operation, anticoagulation, fluid management, prevention and control of infectious diseases, etc.

Inhibitory effects of atractylenolide 3 on platelet and its mechanism / 国际药学研究杂志

Objective To study the effects of atractylenolide 3 on human platelet in vitro and explore the underlying mecha?nism. Methods The effects of atractylenolide 3 on human platelet aggregation induced by thrombus alkane analogues(U46619)was tested by turbidimetry in vitro. ATP secretion weas detected by luciferase detection,and the phosphorylation levels of Erk and Akt were detected by Western blotting. Results Atractylenolide 3 diminished U46619-induced human platelet aggregation in concentra?tion dependence. Compared with DMSO control group,the inhibitory rate were significant increased in each experiment group(P<0.01). Atractylenolide 3 inhibited adenosine triphosphate(ATP)secreted by human platclet in concentration dependence. Compared with the DMSO control group,the inhibitory rate were significant increased in each experiment group(P<0.01),and the levels of phospho-Akt(Ser473)and phospho-Erk1/2 were significant downregulated in the presence of atractylenolide 3 in each experiment group(P<0.01). Conclusion Atractylenolide 3 exhibits a concentration-dependent inhibitory effect on human platelet aggregation and secretion induced by U46619. Also,it regulated the MAPK and PI3K-Akt signaling pathways. These results show that atractyleno?lide 3 is an effective antiplatelet compound,may serve as new antithrombotic drugs.

A CYTOTOXIC METABOLITE OF STREPTOMYCES SP. SC120 / 微生物学通报

During the course of the investigation of the antifungal metabolites against Peronophythora litchii from the fermentation broth of Streptomyces sp SC120, an antibiotics that exhibited the cytotoxicity to CNE 2 was isolated By spectral (UV, IR, HRMS, 1H NMR, 13 C NMR, 1H 1H COSY, HMQC and HMBC) analyses, its structure was identified as pimprinine The cytotoxicity of pimprinine to CNE 2 was reported for the first time