Strain-invariant stretchable radio-frequency electronics.

Wireless modules that provide telecommunications and power-harvesting capabilities enabled by radio-frequency (RF) electronics are vital components of skin-interfaced stretchable electronics1-7. However, recent studies on stretchable RF components have demonstrated that substantial changes in electrical properties, such as a shift in the antenna resonance frequency, occur even under relatively low elastic strains8-15. Such changes lead directly to greatly reduced wireless signal strength or power-transfer efficiency in stretchable systems, particularly in physically dynamic environments such as the surface of the skin. Here we present strain-invariant stretchable RF electronics capable of completely maintaining the original RF properties under various elastic strains using a 'dielectro-elastic' material as the substrate. Dielectro-elastic materials have physically tunable dielectric properties that effectively avert frequency shifts arising in interfacing RF electronics. Compared with conventional stretchable substrate materials, our material has superior electrical, mechanical and thermal properties that are suitable for high-performance stretchable RF electronics. In this paper, we describe the materials, fabrication and design strategies that serve as the foundation for enabling the strain-invariant behaviour of key RF components based on experimental and computational studies. Finally, we present a set of skin-interfaced wireless healthcare monitors based on strain-invariant stretchable RF electronics with a wireless operational distance of up to 30 m under strain.

MATLAB-based innovative 3D finite element method simulator for optimized real-time hyperthermia analysis.

BACKGROUND AND OBJECTIVE: Owing to the significant role of hyperthermia in enhancing the efficacy of chemotherapy or radiotherapy for treating malignant tissues, this study introduces a real-time hyperthermia simulator (RTHS) based on the three-dimensional finite element method (FEM) developed using the MATLAB App Designer. METHODS: The simulator consisted of operator-defined homogeneous and heterogeneous phantom models surrounded by an annular phased array (APA) of eight dipole antennas designed at 915 MHz. Electromagnetic and thermal analyses were conducted using the RTHS. To locally raise the target temperature according to the tumor's location, a convex optimization algorithm (COA) was employed to excite the antennas using optimal values of the phases to maximize the electric field at the tumor and amplitudes to achieve the required temperature at the target position. The performance of the proposed RTHS was validated by comparing it with similar hyperthermia setups in the FEM-based COMSOL software and finite-difference time-domain (FDTD)-based Sim4Life software. RESULTS: The simulation results obtained using the RTHS were consistent, both for the homogeneous and heterogeneous models, with those obtained using commercially available tools, demonstrating the reliability of the proposed hyperthermia simulator. The effectiveness of the simulator was illustrated for target positions in five different regions for both homogeneous and heterogeneous phantom models. In addition, the RTHS was cost-effective and consumed less computational time than the available software. The proposed method achieved 94% and 96% accuracy for element sizes of λ/26 and λ/36, respectively, for the homogeneous model. For the heterogeneous model, the method demonstrated 93% and 95% accuracy for element sizes of λ/26 and λ/36, respectively. The accuracy can be further improved by using a more refined mesh at the cost of a higher computational time. CONCLUSIONS: The proposed hyperthermia simulator demonstrated reliability, cost-effectiveness, and reduced computational time compared to commercial software, making it a potential tool for optimizing hyperthermia treatment.

Conversion of the bronchial tree into a conforming electrode to ablate the lung nodule in a porcine model.

BACKGROUND: Radiofrequency ablation (RFA) is one of the treatment options for lung nodules. However, the need for exact delivery of the rigid metal electrode into the center of the target mass often leads to complications or suboptimal results. To overcome these limitations, a concept of conforming electrodes using a flexible material has been tested in this study. METHODS: A bronchoscopy-guided RFA (CAROL) under a temperature-controlled mode was tested in in-vivo and ex-vivo porcine lungs. Gallium-based liquid metal was used for turning the bronchial tree into temporary RF electrodes. A customized bronchoscopy-guided balloon-tipped guiding catheter (CAROL catheter) was used to make the procedure feasible under fluoroscopy imaging guidance. The computer simulation was also performed to gain further insight into the ablation results. Safety was also assessed including the liquid metal remaining in the body. RESULTS: The bronchial electrode injected from the CAROL catheter was able to turn the target site bronchial air pipe into a temporally multi-tined RF electrode. The mean volume of Gallium for each effective CAROL was 0.46 ± 0.47 ml. The ablation results showed highly efficacious and consistent results, especially in the peripheral lung. Most bronchial electrodes were also retrieved by either bronchoscopic suction immediately after the procedure or by natural expectoration thereafter. The liquid metal used in these experiments did not have any significant safety issues. Computer simulation also supports these results. CONCLUSION: The CAROL ablation was very effective and safe in porcine lungs showing encouraging potential to overcome the conventional approaches.

Lung cancer can be treated by inserting a metal device into the lung via the throat and using this to send radio waves into the cancer. However, using a rigid metal device can cause damage to other areas of the lung and can only treat small cancers. Here, we describe an alternative method to treat lung cancers in which liquid metal is used to fill the spaces within the lung closest to the cancer. We demonstrate that this method can be used to treat cancer in a swine model of lung cancer. Given the positive results we obtained, we think this approach should be tested in a clinical trial in human patients with lung cancer, as it might improve cancer treatment.

Wireless, Battery-Free, and Fully Implantable Micro-Coil System for 7 T Brain MRI.

An elegant solution for the concurrent transmission of data and power is essential for implantable wireless magnetic resonance imaging (MRI). This paper presents a self-tuned open interior microcoil (MC) antenna with three useful operating bands of 300 (7 T), 400, and 920 MHz, for blood vessel imaging, data telemetry, and efficient wireless transmission of power, respectively. The proposed open interior MC antenna contains two mirrorlike arms with diameters and lengths of 2.4 mm and 9.8 mm, respectively, to avoid blood flow blockage. To wirelessly show LED glow on a saline based phantom, the MC was fabricated on a flexible polyimide material and combined with a miniaturized rectifier and a micro-LED. Using a path gain, the power transfer efficiency (PTE) of the MC rotation was also analyzed. Additionally, the PTE was calculated for a range of distances between 25 and 60 mm, and a -27.1 dB PTE attained at a distance of of 30 mm. Based on the recommendations of the International Commission on Non-Ionizing Radiation Protection for human brain safety when exposed to radio-frequencies from external transmitter, a specific absorption rate analysis was analyzed. Measurements of the s-parameters were noted using a saline solution and blood vessel model to imitate a realistic human head. They were found to correlate reasonably with the simulated results.

Development of 60-GHz millimeter wave, electromagnetic bandgap ground planes for multiple-input multiple-output antenna applications.

For 60-GHz band communications, both the mutual coupling and transmission distance restrict the performance of a multiple-input multiple-output (MIMO) antenna array. Several studies presented different types of meta-materials and electromagnetic bandgap (EBG) structures to improve the performance of a MIMO antenna array at the 60-GHz band. In this paper, we presented the four-element MIMO patch antenna with different types of EBG structures for the millimeter wave (mmW)communications at the 60-GHz unlicensed industrial, scientific, and medical band. The single element of the MIMO antenna array covered the mmW band from 57 GHz to 63 GHz having the dimensions of 1.3 mm × 1.8 mm × 0.1 mm. We developed a set of square-shaped, cross-shaped, and complex-slotted EBG ground planes between the antenna elements for the performance improvement. All the three EBG ground planes provided significant coupling reduction between the mmW MIMO antenna elements. The proposed EBG structures exhibited wide bandgap characteristics and improved scattering parameters in the desired frequency band. In contrast with the cross- and complex-slotted, the square-shaped EBG structure substantially improved the overall gain of MIMO antenna array. In addition, the square-shaped EBG reformed the maximum beam and enhanced the far-field gain pattern in the desired direction. Experimental results conducted with the fabricated prototypes showed a good agreement with the simulation results and adequately covered the 60-GHz band. The low-profile and salient features of the proposed MIMO antenna array shows the potential for on-chip applications at 60 GHz.

Soft Materials, Stretchable Mechanics, and Optimized Designs for Body-Wearable Compliant Antennas.

Among the various methods to develop flexible wearable antennas, a serpentine, mesh structure has been a great interest because of its mechanical reliability upon applied strain. However, there is still a significant lack of design guidelines for the open-mesh concept that account for both material and electromagnetic (EM) properties of antennas. In this work, we introduce a comprehensive study of materials, mechanics, fabrication, and system integration for the development of stretchable dipole and patch antennas that have networks of two-dimensional serpentine patterns. A set of computational modeling and experimental validation of open-mesh structures provides the key design guidelines to offer the maximum mechanical stretchability and minimum effective moduli of wearable antennas. Integration of the thin-film antenna traces with various substrates captures the versatility of the deterministic fabrication and material transfer printing methods. The influence of antenna stretching on the EM properties, including return loss, electric and magnetic fields, and far-field radiation patterns, is investigated. EM characterization with mechanical stretching results in different properties of fabricated antennas. The simulation study of specific absorption rates shows a potential for safe applications of dipole and patch stretchable antennas on the human skin.

Fully Printed, Wireless, Stretchable Implantable Biosystem toward Batteryless, Real-Time Monitoring of Cerebral Aneurysm Hemodynamics.

This study introduces a high-throughput, large-scale manufacturing method that uses aerosol jet 3D printing for a fully printed stretchable, wireless electronics. A comprehensive study of nanoink preparation and parameter optimization enables a low-profile, multilayer printing of a high-performance, capacitance flow sensor. The core printing process involves direct, microstructured patterning of biocompatible silver nanoparticles and polyimide. The optimized fabrication approach allows for transfer of highly conductive, patterned silver nanoparticle films to a soft elastomeric substrate. Stretchable mechanics modeling and seamless integration with an implantable stent display a highly stretchable and flexible sensor, deployable by a catheter for extremely low-profile, conformal insertion in a blood vessel. Optimization of a transient, wireless inductive coupling method allows for wireless detection of biomimetic cerebral aneurysm hemodynamics with the maximum readout distance of 6 cm through meat. In vitro demonstrations include wireless monitoring of flow rates (0.05-1 m s-1) in highly contoured and narrow human neurovascular models. Collectively, this work shows the potential of the printed biosystem to offer a high throughput, additive manufacturing of stretchable electronics with advances toward batteryless, real-time wireless monitoring of cerebral aneurysm hemodynamics.

Adaptive Matching Transmitter With Dual-Band Antenna for Intraoral Tongue Drive System.

The intraoral Tongue Drive System (iTDS) is a wireless assistive technology that detects users' voluntary tongue gestures, and converts them to user-defined commands, enabling them to access computers and navigate powered wheelchairs. In this paper, we presented a transmitter (Tx) with adaptive matching and three bands (27, 433, and 915 MHz) to create a robust wireless link between iTDS and an external receiver (Rx) by addressing the effects of external RF interference and impedance variations of the Tx antenna in the dynamic mouth environment. The upper two Tx bands share a dual-band antenna, while the lower band drives a coil. The Tx antenna is simulated in a simplified human mouth model in HFSS as well as a real human head model. The adaptive triple-band Tx chip was fabricated in a 0.35-µm 4P2M standard CMOS process. The Tx chip and antenna have been characterized in a human subject as part of an iTDS prototype under open-and closed-mouth scenarios, which present the peak gain of -24.4 and -15.63 dBi at 433 and 915 MHz, respectively. Two adaptive matching networks for these bands compensate variations of the Tx antenna impedance via a feedback mechanism. The measured S11 tuning range of the proposed network can cover up to 60 and 75 jΩ at 433 and 915 MHz, respectively.

Stepped impedance resonators for high-field magnetic resonance imaging.

Multi-element volume radio-frequency (RF) coils are an integral aspect of the growing field of high-field magnetic resonance imaging. In these systems, a popular volume coil of choice has become the transverse electromagnetic (TEM) transceiver coil consisting of microstrip resonators. In this paper, to further advance this design approach, a new microstrip resonator strategy in which the transmission line is segmented into alternating impedance sections, referred to as stepped impedance resonators (SIRs), is investigated. Single-element simulation results in free space and in a phantom at 7 T (298 MHz) demonstrate the rationale and feasibility of the SIR design strategy. Simulation and image results at 7 T in a phantom and human head illustrate the improvements in a transmit magnetic field, as well as RF efficiency (transmit magnetic field versus specific absorption rate) when two different SIR designs are incorporated in 8-element volume coil configurations and compared to a volume coil consisting of microstrip elements.

A method to localize RF B1 field in high-field magnetic resonance imaging systems.

In high-field magnetic resonance imaging (MRI) systems, B0 fields of 7 and 9.4 T, the RF field shows greater inhomogeneity compared to clinical MRI systems with B0 fields of 1.5 and 3.0 T. In multichannel RF coils, the magnitude and phase of the input to each coil element can be controlled independently to reduce the nonuniformity of the RF field. The convex optimization technique has been used to obtain the optimum excitation parameters with iterative solutions for homogeneity in a selected region of interest. The pseudoinverse method has also been used to find a solution. The simulation results for 9.4- and 7-T MRI systems are discussed in detail for the head model. Variation of the simulation results in a 9.4-T system with the number of RF coil elements for different positions of the regions of interest in a spherical phantom are also discussed. Experimental results were obtained in a phantom in the 9.4-T system and are compared to the simulation results and the specific absorption rate has been evaluated.

Pseudoinverse method for modal solutions of open dielectric waveguides.

The vector finite-element method in the interior and the boundary integral equation of the exterior domain are investigated in order to analyze open dielectric waveguides. Boundary conditions are obtained by applying the continuity of the magnetic and electric fields at the surface of the waveguide. Since both the finite-element method and boundary integral equations have the final matrices of the form Ax=lambdaBx, the pseudoinverse method with a penalty factor is used. This new method provides the simultaneous solutions of propagating modes at the operating frequency, and it shows good agreement with previously published results for the analysis of the rectangular waveguide.

Analysis of open dielectric waveguides using the finite-element penalty method.

This paper analyzes open dielectric waveguides using the vector finite-element method and boundary integral equations derived from the second Green's theorem. This finite-element formulation, together with the boundary operator, is solved using a penalty function method. Comparison with previously published results shows good agreement for the analysis of the rectangular dielectric waveguide.