Role of Physical Activity in the Prevention and Treatment of Influenza: A Review.

BACKGROUND: Many concerns regarding respiratory diseases, including influenza, emerged during the epidemic of COVID-19. There were relevant research findings and suggestions for influenza prevention and treatment through physical activity, but little report about the total efficiency. So, this review was to summarize the role of physical activity in influenza prevention and treatment. MAIN BODY: The databases Web of Science, Google Scholar, EBSCO, PubMed, CNKI, and Science Direct were used to search the related literatures. The first search ran from July to October, 2021, and the second search was conducted in September, 2023. Those publications that reported the effects of physical activity, exercise, and sport on influenza, flu, and cold were included. It found that long-term adherence to moderate physical activity is beneficial in enhancing the body's ability to resist influenza viruses. However, high-intensity endurance physical activity can cause an open window in the human immune system, which increases the risk of infection by influenza viruses. The patients with influenza infections can participate in moderate physical activity during the pre-onset period, but some of the researchers do not recommend physical activity for patients with influenza, avoiding the transmission of influenza viruses to others through human contact of physical activity. Moreover, animal studies have shown that physical activity may worsen influenza disease. While studies found that moderate physical activity is beneficial for preventing influenza, as most experimental studies were conducted on animals, the mechanisms in human with physical activity are still unclear. No study has yet suggested exercise prescriptions to prevent and control influenza, and there is currently no way to prevent or control influenza just through physical activity. The follow-up research is needed to increase human clinical experiments, elucidate the effect of physical activity on influenza, develop exercise prescriptions and gradually promote physical activity as a practical means for preventing and treating influenza. SHORT CONCLUSIONS: Overall, participating in moderate physical activity regularly should be beneficial in influenza prevention, alleviating the patients' symptoms and increasing the recovery efficiency, but this needs more testing in clinical human trials.

Cyanide-Bridged Rope-like Chains Based on Trigonal-Bipyramidal [Fe2Cu3] Subunits.

Extending a selected cyanometalate block into a higher dimensional framework continues to present intriguing challenges in the fields of chemistry and material science. Here, we prepared two rope-like chain compounds of {[(Tp*Me)Fe(CN)3]2Cu2X2(L)}·sol (1, X = Cl, L = (MeCN)0.5(H2O/MeOH)0.5, sol = 2MeCN·1.5H2O; 2, X = Br, L = MeOH, sol = 2MeCN·0.75H2O; Tp*Me = tris(3, 4, 5-trimethylpyrazole)borate) in which the cyanide-bridged trigonal-bipyramidal [Fe2Cu3] subunits were linked with the adjacent ones via two vertex Cu(II) centers, providing a new cyanometallate chain archetype. Direct current magnetic study revealed the presence of ferromagnetic couplings between Fe(III) and Cu(II) ions and uniaxial anisotropy due to a favorable alignment of the anisotropic tricyanoiron(III) units. Moreover, compound 1 exhibits single-chain magnet behavior with an appreciable energy barrier of 72 K, while 2 behaves as a metamagnet, likely caused by the subtle changes in the interchain interactions.

A Proton Conducting Cobalt(II) Spin Crossover Complex.

Spin crossover (SCO) complexes have been extensively explored as bistable materials and recently used as molecular modules for the development of new multifunctional molecular magnetic materials. Herein, we present the synthesis, crystal structure, magnetic, and electrical properties of a mononuclear cobalt complex constructed by a halogen-functionalized terpyridine derivative and organosulfonate. A complete and gradual spin transition with the T1/2 =200 K was observed for the Co2+ ions through both the magnetic measurement and dynamic crystallographic experiments. Interestingly, considerable room temperature proton conductivity of 6.9×10-5  S cm-1 under 98% relative humidity was evidenced because of the presence of sulfonate-assisted hydrogen-bonded proton hopping pathways. The forgoing results not only provide an unprecedented proton-conducting cobalt(II) SCO complex but also a promising way for the design and construction of bifunctional SCO molecular conductors via the incorporation of SCO transition and proton conduction.

Effects of Physical Activity on College Students' Subjective Well-Being During COVID-19.

BACKGROUND: The COVID-19 outbreak has caused widespread psychological distress to Chinese college students. To explore the beneficial psychological effects of physical activity, this study accessed the relationship of Physical Activity (PA) and Subjective Well-being (SWB) among Chinese college students during the pandemic. METHODS: A total of 1198 college students (aged between 17 and 40) from 8 universities in Wuhan, China, volunteered to finish the online questionnaire survey from February 17 to 20, 2020. General Well-Being Schedule (GWBS) was used to evaluate SWB, and Physical Activity Rating Scale-3 (PARS-3) was used to measure PA. The Mann-Whitney U test, χ2 test, t test, and analysis of variance were used to compare the differences between groups based on different data types. A multi-factor linear regression analysis was performed on the factors affecting college students' participation in physical activity during the pandemic. Differences were considered statistically significant when p < .05. RESULTS: It found that: (1) The quality of physical activity during COVID-19 significantly and positively predicted subjective well-being (B = 2.512, p < .001), indicating that physical activity can effectively alleviate adverse mental health effects caused by the pandemic. (2) The pandemic has had a greater impact on the mental health of specific groups (such as seniors and rural college students). Supporting and encouraging them to participate in a certain level of sports activities can improve their subjective well-being, which is helpful for countering the pandemic's adverse effects. (3) People should be encouraged to participate in sports at moderate or high levels. CONCLUSION: PA can effectively alleviate the negative psychological impact of the pandemic. In general, during major public health emergencies, people should be supported and encouraged to regularly participate in physical activities at moderate or higher levels, to improve their subjective well-being, and maintain positive anti-pandemic attitudes and behavior.

[AuI(CN)2]-Armed [FeIII2FeII2] Square Complex Showing Unusual Spin-Crossover Behavior Due to a Symmetry-Breaking Phase Transition.

The incorporation of two different cyanide building blocks of [(TpR)FeIII(CN)3]- and [AuI(CN)2]- into one molecule afforded a novel hexanuclear [FeIII2FeII2AuI2] complex (1·2Et2O), in which the cyanide-bridged [FeIII2FeII2] square was further grafted by two [AuI(CN)2]- fragments as long arms in syn orientations. Complex 1·2Et2O undergoes a gradual spin crossover (SCO) ffrom low-spin (LS) to high-spin (HS) state for the Fe(II) centers upon desolvation. Remarkably, its desolvated phase (1) exhibits a reversible but atypical two-step (sharp-gradual) SCO behavior with considerable hysteresis (21 K). Variable-temperature single-crystal X-ray structural studies reveal that the hysteretic spin transition takes place synchronously with the concerted displacive motions of the molecules, representing another rare example including multistep and hysteretic spin transitions due to the synergetic SCO and structural phase transition.

Manipulating the spin crossover behaviour in a series of cyanide-bridged {FeIII2FeII2} molecular squares through NCE- co-ligands.

Manipulating the transition temperature (T1/2) of spin-crossover (SCO) complexes capable of fulfilling practical criteria through different synthetic strategies is one of the main focuses in the field of molecular magnetism. The reaction of the tricyanometallate precursor [(Tp*)FeIII(CN)3]- and Fe(II) salt with the "facially" tridentate ligand tris(2-pyridyl)phosphine oxide (TPPO) and NCE- anions afforded three isostructural {FeIII2FeII2} square complexes {[(Tp*)FeIII(CN)3]2[FeII(TPPO)]2[NCE]2}·Sol (E = S, Sol = 2CH3OH·6H2O, 1; E = Se, Sol = 2MeCN·2CH2Cl2·2H2O, 2; E = BH3, Sol = 4CH3OH·2MeCN, 3). Detailed structural analysis, variable-temperature IR analysis, magnetic susceptibility measurements and DFT calculations revealed that all compounds exhibit complete and one-step SCO behaviour between the {FeIII,LS2FeII,HS2} and {FeIII,LS2FeII,LS2} electronic states. As the ligand field increases from NCS- to NCSe- to NCBH3-, T1/2 shifts dramatically from 214 to 250 to 288 K for 1, 2 and 3, respectively, demonstrating another effective way to tune the SCO properties of the [FeIII-CN-FeII] systems through the introduction of NCE- co-ligands.

Hydrogen-Bonded Framework of a Cobalt(II) Complex Showing Superior Stability and Field-Induced Slow Magnetic Relaxation.

A unique hydrogen-bonded organic-inorganic framework (HOIF) constructed from a mononuclear cobalt(II) complex, [Co(MCA)2·(H2O)2] (HMCA = 4-imidazolecarboxylic acid), via multiple hydrogen-bonding interactions was synthesized and structurally characterized. The Co(II) center in the HOIF features a highly distorted octahedral coordination environment. Remarkably, the CoII HOIF showed permanent porosity with superior stability as established by combined thermogravimetric analysis (TGA), variable-temperature infrared spectra (IR), variable-temperature powder X-ray diffraction data (PXRD), and a CO2 isotherm. Structural studies reveal that short multiple hydrogen bonds should be responsible for the superior thermal and chemical stability of a HIOF. Magnetic investigations reveal the large easy-plane magnetic anisotropy of the Co2+ ions with the fitted D values being 22.1 (magnetic susceptibility and magnetization data) and 29.1 cm-1 (reduced magnetization data). In addition, the HOIF exhibits field-induced slow magnetic relaxation at low temperature with an effective energy barrier of Ueff = 45.2 cm-1, indicative of a hydrogen-bonded framework single-ion magnet of the compound. The origin of the significant magnetic anisotropy of the complex was also understood from computational studies. In addition, BS-DFT calculations indicate that the superexchange interactions between the neighboring CoII ions are non-negligible antiferromagnetism with JCo-Co = -0.5 cm-1. The foregoing results provide not only a carboxylate-imidazole ligand approach toward a stable HOIF but also a promising way to build a robust single-ion magnet via hydrogen-bond interactions.

An azido-bridged [FeII4] grid-like molecule showing spin crossover behaviour.

The supramolecular self-assembly synthetic strategy provides a valid tool to obtain polynuclear Fe(II) complexes having effective communication between the metal centres and distinct spin crossover behaviour. Despite the great success in constructing various magnetic molecules, progress has not been made in SCO complexes based on azido bridges. In this article, the coordination-driven supramolecular assembly based on 3,6-substituted pyridazine and azide is presented to afford two Fe(II) grid-like complexes: [(L)4FeII4(N3)4][BPh4]4·sol (1, L = 3,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine and 2, L = 3,6-di(pyridin-2-yl)pyridazine). The substitution of pyridinyl groups in 2 instead of pyrazolyl ones in 1 led to the only example exhibiting spin-crossover behaviour (T1/2 = 230 K) among the azido-bridged complexes. In addition, a temperature-dependent photoluminescence study of 2 demonstrates a visible synergetic effect between the SCO event and the luminescence.

Spread of Coronavirus 2019 From Wuhan to Rural Villages in the Hubei Province.

BACKGROUND: This study aimed to describe the spread of coronavirus disease 2019 (COVID-19) from Wuhan to rural villages in the Hubei Province. METHODS: The analysis revealed the following: (1) COVID-19 spread from Wuhan to other cities and rural areas in Hubei, but the disease did not become widespread in rural villages because of strict prevention measures and urbanization; (2) according to the fluctuation in the number of confirmed cases reported in Hubei after January 23, 2020, we inferred that the infected patients on the same day will become ill during the next 20 days; (3) the advanced traffic system facilitates the direct spread of COVID-19 from Wuhan to counties, towns, and villages in the Hubei Province. RESULTS: There is a low possibility of COVID-19 spread from prefecture-level cities to rural areas. CONCLUSIONS: The findings imply that the government should limit the travelers from the cities to the rural areas, pay more attention to the prevention and control of severe acute respiratory syndrome coronavirus 2 in cities, and appropriately prolong the isolated observation period of travelers.