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2.
Head Neck Pathol ; 16(2): 567-572, 2022 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-34255277

RESUMEN

Secretory carcinoma (SC) of salivary gland, previously known as mammary analogue secretory carcinoma, is a rare low-grade malignancy harboring a diagnostic ETV6-NTRK3 gene fusion. SC of salivary gland shares histopathological, immunohistochemical and genetic characteristics with SC of the breast. There are several previous cytomorphological characterizations of SC of salivary gland reported in the literature. The most commonly reported patterns are of epithelial clusters with papillary architectural features, or of single dispersed epithelial cells on a background of abundant histiocytes. Tumor cells exhibit vacuolated eosinophilic cytoplasm and round to oval nuclei with regular nuclear contours and inconspicuous or small nucleoli. The cytomorphology of SC may closely mimic that of acinic cell carcinoma or low-grade mucoepidermoid carcinoma. Moreover, when cohesive epithelial clusters do not appear on the smears, it may be very difficult to distinguish dispersed tumor cells from histiocytes. In this article, we review the literature pertaining to SC cytomorphology and we report a fine needle aspiration biopsy case of SC in salivary gland showing well-defined intracytoplasmic hyaline globules, a feature that has not been previously reported. This novel cytomorphological feature may be helpful in distinguishing the tumor cells of SC from histiocytes and from other low-grade salivary gland tumors.


Asunto(s)
Carcinoma , Carcinoma Secretor Análogo al Mamario , Neoplasias de las Glándulas Salivales , Biomarcadores de Tumor , Biopsia con Aguja Fina , Neoplasias de la Mama , Carcinoma/patología , Humanos , Carcinoma Secretor Análogo al Mamario/diagnóstico , Carcinoma Secretor Análogo al Mamario/genética , Proteínas de Fusión Oncogénica/genética , Neoplasias de las Glándulas Salivales/patología , Glándulas Salivales/patología
3.
Diagn Cytopathol ; 40 Suppl 2: E144-8, 2012 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-21548124

RESUMEN

Cytological diagnosis of low grade sarcomas can be a daunting task, owing to the varied cytomorphological appearances possible. We report a case of acral myxoinflammatory fibroblastic sarcoma (AMIFS) in a woman who presented with a longstanding mass on the dorsum of her left foot. The diagnosis was suggested by fine needle aspiration cytology and established by wide excision. Microscopic examination showed that fine needle aspirate smears of this lesion contained the characteristic features seen in the surgical excision of this AMIFS: myxoid material, spindled to epithelioid cells with variably prominent nucleoli, nuclear pseudoinclusions, bipolar cytoplasmic extensions, globules of extracellular material, and bizarre virocyte or ganglion-like giant cells.


Asunto(s)
Fibroma/patología , Fibrosarcoma/patología , Pie/patología , Inflamación/patología , Adulto , Biopsia con Aguja Fina , Femenino , Humanos
4.
J Mol Diagn ; 13(2): 160-6, 2011 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-21354050

RESUMEN

Testing for high-risk (HR) human papillomavirus (HPV) is a key component of current recommendations for cervical cancer screening. Herein is described our clinical experience using Cervista HPV HR, a testing platform recently approved by the US Food and Drug Administration for clinical use. Using data from a high-volume commercial laboratory, a retrospective analysis of cytologic and Cervista HPV HR test results from 56,501 samples was performed, and an indirect comparison was made with previous experience with 53,008 samples tested using the Hybrid Capture 2 platform. Of samples analyzed using Cervista HPV HR, 1.5% were of insufficient volume for testing and 1.1% yielded an insufficient signal from the internal control to be reported. In samples with a cytological interpretation of atypical squamous cells of undetermined significance, 48.5% (95% confidence interval [CI], 47.5 to 49.5) tested positive using Cervista HPV HR, compared with 59.4% (95% CI, 58.3 to 60.5) of samples using Hybrid Capture 2. Of samples from women aged 30 years or older with a negative cytological interpretation, 5.8% (95% CI, 5.6 to 6.1) tested positive using Cervista HPV HR, compared with 5.5% (95% CI, 5.3 to 5.7) of samples using Hybrid Capture 2. When stratified by five-year age groups between 30 and 65 years, positivity rates for high-risk human papillomavirus were similar in the Cervista HPV HR and Hybrid Capture 2 populations, and were consistent with expectations established by the literature.


Asunto(s)
Técnicas Citológicas , Papillomaviridae/aislamiento & purificación , Infecciones por Papillomavirus/diagnóstico , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Cuello del Útero/citología , Cuello del Útero/patología , Cuello del Útero/virología , Niño , Detección Precoz del Cáncer , Femenino , Humanos , Persona de Mediana Edad , Papillomaviridae/genética , Infecciones por Papillomavirus/virología , Estudios Retrospectivos , Neoplasias del Cuello Uterino/diagnóstico , Neoplasias del Cuello Uterino/patología , Neoplasias del Cuello Uterino/virología , Adulto Joven
5.
Diagn Cytopathol ; 39(3): 204-9, 2011 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-20607745

RESUMEN

Thyroid carcinoma showing thymus-like differentiation (CASTLE) is a rare tumor of the thyroid gland or adjacent soft tissues of the neck. Given the comparatively good prognosis of CASTLE, it is crucial to distinguish this neoplasm from other more aggressive thyroid neoplasms that can have similar or overlapping cytomorphological features. However, there is little information about the cytomorphology of CASTLE available in the literature. Here we report the cytomorphology and histology of thyroid CASTLE in a 52-year-old woman and present a review of the literature.


Asunto(s)
Diferenciación Celular , Técnicas Citológicas/métodos , Timo/patología , Neoplasias de la Tiroides/patología , Agregación Celular , Cromatina/patología , Femenino , Humanos , Inmunohistoquímica , Persona de Mediana Edad
6.
Mod Pathol ; 23(1): 134-43, 2010 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-19838160

RESUMEN

Cell surface expression of glucose-regulated protein 78 (GRP78) occurs in several types of cancer; however, its role in the behavior of primary cutaneous melanoma is not well studied. The association of cell surface GRP78 with other proteins such as MTJ1 stimulates cell proliferation. In this study, we characterized the pattern of expression of GRP78 and MTJ1 in invasive primary cutaneous melanomas and analyzed the relationships between the pattern of expression and various clinicopathological parameters. We found two patterns of GRP78 expression in invasive primary cutaneous melanoma. One pattern showed a gradual fading of protein expression from superficial to deeper levels within the same tumor. The second pattern of expression showed a similar fading with an abrupt regaining of expression at the deep invasive edge of the melanoma. These two distinct patterns of GRP78 expression correlated with both patient survival and depth of tumor invasion. A moderate MTJ1 expression was found to be associated with decreased patient survival; however, no significant associations were observed between patterns of GRP78 and MTJ1 expression. Our study (1) describes two distinct patterns of GRP78 in invasive primary cutaneous melanoma, (2) inversely correlates regain of GRP78 expression with patient survival, and (3) suggests a modifying effect of MTJ1 on GRP78 in enhancing tumor aggressiveness.


Asunto(s)
Biomarcadores de Tumor/análisis , Proteínas del Choque Térmico HSP40/biosíntesis , Proteínas de Choque Térmico/biosíntesis , Melanoma/metabolismo , Proteínas de la Membrana/biosíntesis , Neoplasias Cutáneas/metabolismo , Adulto , Anciano , Chaperón BiP del Retículo Endoplásmico , Femenino , Humanos , Inmunohistoquímica , Estimación de Kaplan-Meier , Masculino , Melanoma/mortalidad , Melanoma/patología , Persona de Mediana Edad , Estadificación de Neoplasias , Pronóstico , Neoplasias Cutáneas/mortalidad , Neoplasias Cutáneas/patología
7.
Arch Pathol Lab Med ; 132(10): 1683-7, 2008 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-18834231

RESUMEN

Extranodal follicular dendritic cell sarcoma is a rare tumor of follicular dendritic cells that can occur in a wide variety of sites. Although fairly well characterized histologically, with a distinct immunophenotype, it remains under-recognized, with as many as one third of cases initially misdiagnosed. This is often due to a failure to consider the entity. Patients with this tumor may have a worse prognosis than originally described. Prompted by a recent case at our institution, we briefly review the clinical features, etiology, histologic, and cytologic appearance of the tumor, as well as the ancillary studies useful in resolving diagnostic issues, primarily in an attempt to increase recognition of this rare neoplasm.


Asunto(s)
Sarcoma de Células Dendríticas Foliculares/diagnóstico , Sarcoma de Células Dendríticas Foliculares/patología , Sarcoma de Células Dendríticas Foliculares/terapia , Diagnóstico Diferencial , Humanos , Pronóstico
8.
Orbit ; 27(3): 223-5, 2008.
Artículo en Inglés | MEDLINE | ID: mdl-18569835

RESUMEN

PURPOSE: To report a case of an unusual orbital tumor with histologic features of both neurofibroma and schwannoma. METHODS: Clinical and pathological findings are presented in a patient with an orbital tumor. RESULTS: Orbital magnetic resonance imaging in a 51-year-old female revealed a heterogeneously enhancing right orbital mass. An anterior orbitotomy was performed, and pathological evaluation revealed a tumor with discrete areas of both neurofibroma and schwannoma. CONCLUSIONS: Hybrid neurofibroma-schwannomas may arise within the orbit.


Asunto(s)
Neurilemoma/patología , Neurofibroma/patología , Órbita/cirugía , Neoplasias Orbitales/patología , Biopsia con Aguja , Femenino , Estudios de Seguimiento , Humanos , Inmunohistoquímica , Imagen por Resonancia Magnética , Persona de Mediana Edad , Neurilemoma/cirugía , Neurofibroma/cirugía , Procedimientos Quirúrgicos Oftalmológicos/métodos , Neoplasias Orbitales/cirugía , Medición de Riesgo , Resultado del Tratamiento
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