Analyzing the effect of blue-blocking lenses on color vision tests using the chromaticity coordinate method.

Significance: Blue light with wavelengths of 380-445 nm can harm the retina, leading to the development of blue-blocking lenses (BBLs). Understanding whether BBLs affect color vision test outcomes and color discrimination ability is crucial for people in color-associated jobs. Aim: This study aimed to evaluate the effect of BBLs on color vision tests and analyze color discrimination using mathematical models of color spaces. Approach: Six pseudoisochromatic (PIC) tests and two Farnsworth-Munsell (FM) tests were conducted to assess participants' color vision. Friedman signed rank test was used to compare the outcomes of the Farnsworth-Munsell 100-Hue Tests (FM 100-Hue Tests) between the BBLs and ordinary lenses groups. The CIE color difference formula and a spectral illuminometer were employed to evaluate the color differences with and without BBLs. Results: All subjects showed normal outcomes in all PIC tests and Farnsworth-Munsell Dichotomous D-15 Tests (FM D-15 Tests). There were no significant differences between ordinary lenses group and BBLs groups in FM 100-Hue Tests. In the color space, the effect of BBLs on each color light was equivalent to a translation on the CIE 1931 chromaticity diagram with minor distortion. Since BBLs do not disrupt the continuity of the chromaticity diagram, or cause different colors to appear the same, they do not lead to color confusion. However, colors with short wavelengths exhibited more changes in color difference when wearing BBLs. Conclusions: BBLs do not impair the wearer's ability to discriminate colors or perform color vision tests accurately. However, BBLs can cause color differences especially in the recognition of blue hues.

Metasurface-based optical system for miniaturization of atomic magnetometers.

Recent research has focused on miniaturizing atomic devices like magnetometers and gyroscopes for quantum precision measurements, leading to energy savings and broader application. This paper presents the design and validation of metasurface-based optical elements for atomic magnetometers' optical paths. These include highly efficient half-wave plates, polarizers, circular polarization generators, polarization-preserving reflectors, and polarizing beam splitters. These components, compatible with semiconductor manufacturing, offer a promising solution for creating ultra-thin, compact atomic devices.

Mosaic Patterned Surfaces toward Generating Hardly-Volatile Capsular Droplet Arrays for High-Precision Droplet-Based Storage and Detection.

Precise detection involving droplets based on functional surfaces is promising for the parallelization and miniaturization of platforms and is significant in epidemic investigation, analyte recognition, environmental simulation, combinatorial chemistry, etc. However, a challenging and considerable task is obtaining mutually independent droplet arrays without cross-contamination and simultaneously avoiding droplet evaporation-caused quick reagent loss, inaccuracy, and failure. Herein, a strategy to generate mutually independent and hardly-volatile capsular droplet arrays using innovative mosaic patterned surfaces is developed. The evaporation suppression of the capsular droplet arrays is 1712 times higher than the naked droplet. The high evaporation suppression of the capsular droplet arrays on the surfaces is attributed to synergistic blocking of the upper oil and bottom mosaic gasproof layer. The scale-up of the capsular droplet arrays, the flexibility in shape, size, component (including aqueous, colloidal, acid, and alkali solutions), liquid volume, and the high-precision hazardous substance testing proves the concept's high compatibility and practicability. The mutually independent capsular droplet arrays with amazingly high evaporation suppression are essential for the new generation of high-performance open-surface microfluidic chips used in COVID-19 diagnosis and investigation, primary screening, in vitro enzyme reactions, environmental monitoring, nanomaterial synthesis, etc.

A hybrid magnetometer towards femtotesla sensitivity under ambient conditions.

Detecting magnetic field is of great importance for many applications, such as magnetoencephalography and underground prospecting. There have been many magnetometers being widely used since the age of Hall magnetometer. One of the magnetometers, the superconducting quantum interference device, is capable of measuring femtotesla magnetic fields at cryogenic temperature. However, a solid-state magnetometer with femtotesla sensitivity under ambient conditions remains elusive. Here we present a hybrid magnetometer based on the ensemble nitrogen-vacancy centers in diamond with the sensitivity of (195±60)fT/Hz1/2 under ambient conditions, which can be further advanced to 11fT/Hz1/2 at 100 Hz with cutting-edge fabrication technologies. Our method will find potential applications in biomagnetism and geomagnetism.

Chinese herbal medicine Xinji pill protects the heart from ischemia/reperfusion injury through the Akt/Nrf2 pathway.

The cardioprotective drugs used for treatment against ischemia/reperfusion (MI/R) injury have been well evaluated and are considered inadequate. The Chinese herbal medicine formula, Xinji pill (XJP) has been used traditionally for the prevention and treatment of ischemic heart diseases for decades. In the present study, the cardioprotective effects of XJP against MI/R injury were assessed in vivo and its possible mechanism was examined. Male Sprague­Dawley rats were selected for establishing an MI/R model, which was induced by ischemia for 30 min followed by 24 h reperfusion. Drugs and saline were administered intragastrically from day 14 prior to MI/R. Blood samples were collected for biochemical detection. The rats were then sacrificed and cardiac muscle tissues were harvested. The mRNA expression levels of antioxidant genes were measured by reverse transcription­quantitative polymerase chain reaction and the protein levels were measured by western blotting. Pretreatment with XJP for 14 days protected the heart against I/R­induced myocardial function disorder, protected against heart injury, as demonstrated by normalized serum levels of lactate dehydrogenase and creatine kinase, and suppressed oxidative stress. XJP markedly upregulated the expression of antioxidant genes, including superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase, and promoted the protein expression of heme oxygenase­1 and NFE2­related factor 2 (Nrf2) in the heart tissues. Furthermore, Akt kinase was confirmed to be upstream of Nrf2 in the XJP treatment. LY294002, a specific inhibitor of Akt, significantly eliminated the cardioprotective effects of XJP. In conclusion, these results demonstrated that XJP exhibited notable cardioprotective properties, in which the Akt/Nrf2 signaling pathway may be involved.