Ni3 S2 -Ni Hybrid Nanospheres with Intra-Core Void Structure Encapsulated in N-Doped Carbon Shells for Efficient and Stable K-ion Storage.

Iron group metals chalcogenides, especially NiS, are promising candidates for K-ion battery anodes due to their high theoretical specific capacity and abundant reserves. However, the practical application of NiS-based anodes is hindered by slow electrochemical kinetics and unstable structure. Herein, a novel structure of Ni3 S2 -Ni hybrid nanosphere with intra-core voids encapsulated by N-doped carbon shells (Ni3 S2 -Ni@NC-AE) is constructed, based on the first electrodeposited NiS nanosphere particles, dopamine coating outer layer, oxygen-free annealing treatment to form Ni3 S2 -Ni core and N-doped carbon shell, and selective etching of the Ni phase to form intra-core void. The electron/K+ transport and K+ storage reaction kinetics are enhanced due to shortened diffusion pathways, increased active sites, generation of built-in electric field, high K+ adsorption energies, and large electronic density of states at Fermi energy level, resulting from the multi-structures synergistic effect of Ni3 S2 -Ni@NC-AE. Simultaneously, the volume expansion is alleviated due to the sufficient buffer space and strong chemical bonding provided by intra-core void and yolk-shell structure. Consequently, the Ni3 S2 -Ni@NC-AE exhibits excellent specific capacity (438 mAh g-1 at 0.1 A g-1 up to 150 cycles), outstanding rate performances, and ultra-stable long-cycle performance (176.4 mAh g-1 at 1 A g-1 up to 5000 cycles) for K-ion storage.

LncRNA LOC285758 Induced Non-Small Cell Lung Cancer Development through Up-Regulating CDK6 by Sponge Adsorption of miRNA-204.

Background: Non-coding RNA played one pivotal role in NSCLC in terms of pathogenesis and progression. We aimed to determine the LncRNA, which can be one new potential target for NSCLC treatment and its possible mechanisms from Jan 2017 to Aug 2020. Methods: Gene LOC285758, which produced new cells in tumor cellular system, was knocked out. Its specific effects were tested in terms of cellular phenotype. LOC285758 was chosen to target for miRNA as well as downstream mRNA targeted by miRNA, which verified the combination predicted before. Specific impacts brought from miRNA on NSCLC cells were examined. At last, dynamic impacts produced through miRNA and LOC285758 on mRNA expression and NSCLC cellular phenotype were examined. Results: LOC285758 expression was up-regulated in tissues and cells from NSCLC. Knocking out gene LOC285758 could repress cellular survival and migration of A549 and H292 cells. miRNA-204 was repressed via LOC285758 targeting. miRNA-204 over-expressing repressed invasion ability of NSCLC cells and CDK6 targeted by miRNA-204. CDK6 knocking out suppressed survival and migration of NSCLC cells. The influence brought from gene LOC285758 knocking out could be reversed through suppressing miRNA-204, causing up-regulated CDK6 as well as LOC285758 expression in NSCLC tissues. miRNA-204 was negatively correlated with CDK6 as well as LOC285758, respectively. Nonetheless, CDK6 possessed the positive relationship with LOC285758. Conclusion: An axis of lncRNA LOC285758/miRNA-204/CDK6 can modulate NSCLC cells in terms of migration as well as survival.

Influences of pH and EDTA Additive on the Structure of Ni Films Electrodeposited by Using Bubble Templates as Electrocatalysts for Hydrogen Evolution Reaction.

The structure of Ni films is essential to their electrocatalytic performance for hydrogen evolution reaction (HER). The pH value and EDTA (ethylene diamine tetraacetic acid) additive are important factors for the structure control of electrodeposited metal films due to their adjustment of metal electrocrystallization and hydrogen evolution side reactions. The structures of Ni films from 3D (three-dimensional) porous to compact and flat structure are electrodeposited by adjusting solution pH values or adding EDTA. It is found that when pH value increases from 7.7 to 8.1, 3D porous films change to compact films with many protrusions. Further increasing the pH value or adding 0.1 M EDTA causes compact and flat films without protrusions to appear. When pH ≤ 7.7, hydrogen bubbles with large break-off diameter are easily adsorbed on film surface acting as porous structure templates, and the electroactive ion species, Ni2+ and Ni(NH3)n2+ complexes with low coordination number (n ≤ 3), possess high reduction overpotential, which is beneficial to forming protrusions and smaller particles. So, porous Ni films are electrodeposited. In solutions with pH ≥ 8.1 or 0.1 M EDTA, Ni(NH3)n2+ complexes with high coordination number (6 ≥ n ≥ 3) and hexadentate chelate are formed. Due to the improved wettability, bubbles with a small break-off diameter rapidly detach the film surface resulting in strong stirring. The reduction overpotential is reduced, leading to the formation of larger particles. Therefore, the solution leveling ability increases, and it is difficult to form protrusions, thus it forms a compact and flat film. The 3D porous film exhibits excellent catalytic performance for HER due to the large catalytic activity area.