RESUMEN
Synergistic therapy with nanocarriers is a promising strategy for effective cancer treatment. Here, we synthesized an amphiphilic rhomboidal metallacycle M, in which a glucose-modified pyridine ligand was used to improve water-solubility and an organoplatinum(II) receptor acted as a platinum-based anticancer agent. Moreover, because of the amphiphilic properties, M self-assembled into micelles or nanobelts at different concentrations, and a drug delivery system (DDS) was developed by encapsulating the anticancer drug doxorubicin (DOX) into the micelles. The morphology, cell uptake, cytotoxicity, internalization, and antitumor effect of the DDS were investigated. Under low intracellular pH conditions, the DDS disassembled to release the loaded DOX in situ. The designed DDS exhibited good biocompatibility, synergistic antitumor efficacy, and negligible adverse effects in a U87 tumor-bearing mice model.
RESUMEN
Supramolecular polymers have received considerable attention during the last few decades due to their scientific value in polymer chemistry and profound implications for future developments of advanced materials. Discrete supramolecular coordination complexes (SCCs) with well-defined size, shape, and geometry have been widely employed to construct hierarchical systems by coordination-driven self-assembly with the spontaneous formation of metal-ligand bonds, which results in the formation of well-defined two-dimensional (2D) metallacycles or three-dimensional (3D) metallacages with high functionalities. The incorporation of discrete SCCs into supramolecular polymers by the orthogonal combination of metal-ligand coordination and other noncovalent interactions or covalent bonding could further facilitate the construction of novel supramolecular polymers with hierarchical architectures and multiple functions including controllable uptake and release of guest molecules, providing a flexible platform for the development of smart materials. In this review, the recent progress in metallacycle/metallacage-cored supramolecular polymers that were constructed by the combination of metal-ligand interactions and other orthogonal interactions (including hydrophobic or hydrophilic interactions, hydrogen bonding, van der Waals forces, π-π stacking, electrostatic interactions, host-guest interactions and covalent bonding) has been discussed. In addition, the potential applications of metallacycle/metallacage-cored supramolecular polymers in the areas of light emitting, sensing, bio-imaging, delivery and release, etc., are also presented.
