RESUMEN
Overconsumption of palatable food may initiate neuroadaptive responses in brain reward circuitry that may contribute to eating disorders. Here we report that high-fat diet (HFD) consumption impedes threat-cue-induced suppression of sucrose-seeking in mice. This compulsive sucrose-seeking was due to enhanced cue-triggered neuronal activity in the anterior paraventricular thalamus (aPVT) resulting from HFD-induced microglia activation. Thus, metabolic inflammation in the aPVT produces an adaptive response to threat cues, leading to compulsive food-seeking.
Asunto(s)
Núcleos Talámicos Anteriores , Sacarosa , Animales , Conducta Compulsiva , Señales (Psicología) , Dieta Alta en Grasa/efectos adversos , Inflamación/inducido químicamente , Ratones , Recompensa , Sacarosa/metabolismoRESUMEN
A new type of instrument that called the rapid determination of carbon dioxide combining power without mercury is proposed. The performance of the instrument in accordance to the requirements in ISO15189 of laboratory accreditation has been evaluated. The results showed that, this instrument is safe, pollution-free, accurate and practical.
