RESUMEN
[Bischofit-based ointment was found to produce a stimulatory effect on the regeneration processes in wounds and the biomechanical properties of scar tissues in both infected and uninfected wounds]
Asunto(s)
Cicatriz/tratamiento farmacológico , Compuestos de Magnesio/farmacología , Minerales/farmacología , Infecciones Estafilocócicas/tratamiento farmacológico , Staphylococcus aureus , Infección de Heridas/tratamiento farmacológico , Heridas y Lesiones/tratamiento farmacológico , Animales , Cicatriz/microbiología , Cicatriz/fisiopatología , Masculino , Pomadas , Ratas , Piel/microbiología , Piel/fisiopatología , Infecciones Estafilocócicas/fisiopatología , Cicatrización de Heridas/efectos de los fármacos , Infección de Heridas/fisiopatología , Heridas y Lesiones/microbiología , Heridas y Lesiones/fisiopatologíaRESUMEN
We compared gastroprotective characteristics of synthetic prostaglandin E1 misoprostol and amino acid taurine on rat model of monochloramine injury to the gastric mucosa. Both substances exhibited a pronounced gastroprotective effect.
Asunto(s)
Cloraminas/toxicidad , Misoprostol/farmacología , Úlcera Gástrica/inducido químicamente , Úlcera Gástrica/prevención & control , Taurina/farmacología , Animales , Femenino , Masculino , RatasRESUMEN
This study was designed as a comparative experimental analysis of the gastroprotective effects of two H2-blocking agents--famotidine and benzimidazole compound 64--on the model rat stomach Helicobacter-like mucous lesions. Both substances demonstrated dose-dependent gastroprotective effects both on the macro- and microscopic levels. ED50 made up 21.8 mg/kg and 13.5 mg/kg, respectively.
Asunto(s)
Famotidina/uso terapéutico , Mucosa Gástrica/efectos de los fármacos , Infecciones por Helicobacter/complicaciones , Antagonistas de los Receptores H2 de la Histamina/uso terapéutico , Úlcera Gástrica/tratamiento farmacológico , Animales , Modelos Animales de Enfermedad , Femenino , Mucosa Gástrica/patología , Masculino , Necrosis , Ratas , Úlcera Gástrica/etiología , Úlcera Gástrica/patologíaRESUMEN
20 uteri, 80 placentas and the hearts of 66 normal fetuses from rheumatic mothers have been studied. Exacerbations of rheumatism were observed in some mothers during pregnancy. Sclerosis with enhanced synthesis of collagen type I, III, IV, V and fibronectin was observed in ECM when rheumatism during the pregnancy was not active. Activation of rheumatism during the pregnancy was followed by disturbances of synthesis of interstitial and membrane collagen types, alteration of stromal-parenchymatous relations and development of dyschronosis in the placenta and fetal heart. The study of the heart from children aged 3 months-14 years showed a long-term effect of maternal rheumatism.
Asunto(s)
Matriz Extracelular/inmunología , Miocardio/inmunología , Placenta/inmunología , Efectos Tardíos de la Exposición Prenatal , Enfermedades Reumáticas/inmunología , Útero/inmunología , Adolescente , Adulto , Niño , Preescolar , Colágeno/inmunología , Matriz Extracelular/patología , Femenino , Fibronectinas/inmunología , Corazón/embriología , Humanos , Inmunohistoquímica , Lactante , Miocardio/patología , Placenta/patología , Embarazo , Enfermedades Reumáticas/congénito , Enfermedades Reumáticas/patología , Útero/patologíaRESUMEN
38 adenomatous polyps, 42 villous polyps with varying degree of proliferation and epithelial dysplasia, 34 polyps with preinvasive cancer components and 44 polyps containing invasive cancer elements were examined microspectrophotometrically. The analysis established an increased level of epithelial cells with ploidy varying 3c-5c to be a characteristic feature of the initial stages of malignant transformation of rectal polyps. The invasive cancer had similar peculiarities.