[Capital management of public health as the most important priority of regional socio-demographic policy].

The health of the population is the highest value, therefore, an effectively functioning system of protecting the health of citizens is the most important priority of regional socio-demographic policy and national security. The purpose of the study is to consider the most important priority of socio-demographic policy - capital management of public health in the regions of the Russian Federation. The relevance of the research topic is due to the fact that currently the conditions of the domestic health care system are extremely complex. Health capital management is a key socio-demographic task on a global scale, which ensures well-being both from the perspective of current socio-economic development, which is measured by the efficiency of the use of human capital, and from the point of view of the long-term effect of improving people's lives.

[The trends and perspectives of development of medical tourism].

The article demonstrates that over the past few years medical tourism market goes through significant changes . This especially relates to regional economy and its aspects in the field of tourism. The article presents an important conclusion that nowadays the top-priority factor in the development of medical tourism is a number of crisis points in provision of health tourism services both in the regions of Russia and in the capital region that are related to pandemic and its consequences. The article considers complex of factors related just to epidemiological crisis and its consequences? including economic and social factors related to health-preserving technologies of medical tourism industry. The actual condition of tourism industry, as a branch of the Russian economy,demonstrates that it was among the first ones hit by the pandemic. The article emphasizes that due to emerging problematic trends during epidemics and their aftermaths the possibilities of providing medical tourism services and their concentration in the country, costs and conditions are changing that undoubtedly impact the economic component and health ecology aspects. The conclusion is made that among main conditions of adjustment of medical tourism industry to the new economic conditions are to be truly multidimensional and structured directions and tools that can be applied to look for way out of difficult situations when sales of medical services have fallen to zero, and companies are forced to work out on solutions emerging problems and to make plans of operational way out of existing crisis.

Tumor-Infiltrating Lymphocytes in Breast Cancer. Association with Clinical and Pathological Parameters.

In patients with primary resectable breast cancer, a positive correlation between the age and the count of CD16+ lymphocytes and a negative correlation of this parameter with the number of regulatory CD4+CD25+CD127- cells and proliferative activity of Ki-67 tumor cells were revealed. Higher level of Ki-67 was associated with reduced number of effector lymphocytes (CD8+ and CD16+) and elevated content of regulatory CD8+CD11b-CD28- T cells. The absence of expression of estrogen receptors was associated with reduced cytotoxic potential of CD8+ T cell in comparison with ER+ breast cancer. The percentage of CD8+ lymphocytes (CD3+CD8+ and CD8+CD11b+CD28+) among lymphocytes infiltrating the tumor was higher in PR+ breast cancer than in PR- tumors. With increasing the tumor load, the number of lymphocytes expressing CD16 marker and their cytotoxic potential decreased.

[Current approaches to laboratory diagnosis of syphilis].

The efficiency of chemiluminescence immunoassay (CIA) used as a treponemal test in the serological diagnosis of syphilis was evaluated, by applying the serum samples of 219 patients screened for syphilitic infection. The efficiency of CIA was evaluated in two steps: (1) comparison of the results of tests using the IMMULITE 2000 Syphilis Screen and LIAISON Syphilis screen reagent kits; (2) that of the results of tests applying the IMMULITE 2000 Syphilis Screen and Recombi Best antipallidum-summary antibodies kits. A 100% correlation was found when comparing the results of tests employing the IMMULITE 2000 Syphilis Screen and DiaSorin LIAISON Syphilis Screen kits (n=66). Comparison of CIA using the IMMULITE 2000 Syphilis Screen kits versus that applying the Recombi Best antipallidum-summary antibodies kits (n=153) revealed 3 discordant samples, which amounted to 1.96% of the number of results. Evaluation of the impact of related microorganisms on the detection of T. pallidum antibodies (n= 140) with the IMMULITE 2000 Syphilis Screen kit indicated no interference or cross-reactivity.