Giant Lipoma in the Fronto-Temporo-Parietal Region in an Adult Man: Case Report and Literature Review.

Lipoma belongs to a group of benign mesenchymal tumors. It is in the form of soft masses of adipose tissue encapsulated by a thin layer of fibrous tissue and usually localized subcutaneously. The tumor most often appears in the upper part of the body. Lipomas tend to grow slowly and are small (less than 5cm) lesions. Larger tumors are rare. In this article, we present the case of a patient with a giant head lipoma in the fronto-temporo-parietal region. Both tumor size and location are unique and no such case has been described in the literature so far.

Changes of cytotoxicity of Ti-6Al-4V alloy made by DMLS technology as effect of the shot peening.

OBJECTIVE: The aim the study was to investigate the impact of the shot peening process on the condition of the surface layer and biological properties of titanium alloy produced by means of the Direct Metal Laser Sintering (DMLS) method. MATERIAL AND METHODS: Specimens were prepared by the EOSINT M280 metal sintering laser system. The surfaces were subjected to the shot peening process using three different media, i.e. steel shot, nutshell granules and ceramic beads, after which they were subjected to profilometric analysis, scanning electron microscopic (SEM) observations and energy dispersive X-ray spectroscopy (EDS) tests, as well as to assessment of biological compatibility in terms of cytotoxicity (SH-SY5Y cell lines). RESULTS: The general results obtained from the tests indicate satisfactory biocompatibility of the examined surfaces and that the impact of the shot peening process on the titanium alloy cytotoxicity is acceptable. CONCLUSIONS: The lowest cytotoxicity was demonstrated by the surfaces modified by ceramic beads than the nutshells and the biggest steel shot correspondingly. Moreover, the shot peening process carried out by means of CrNi steel and ceramic shot caused the reduction of surface roughness when, for the surface processing by means of nutshell granules, the increase of surface roughness was observed compared with the unmodified surface of titanium alloy samples.

Effect of Shot Peening on the Mechanical Properties and Cytotoxicity Behaviour of Titanium Implants Produced by 3D Printing Technology.

Structural discontinuities characterize the implants produced directly from metal powders in 3D printing technology. Mainly, the surface defects should be subjected to procedures associated with surface layer modification (likewise shot peening) resulting in the increase of the implant service life maintaining optimal biocompatibility. Therefore, the purpose of the present study was to investigate the effect of type of shot used for the peening process on the Ti-6Al-4V implants functional properties as well as the biological properties. The components were produced by DMLS (direct metal laser sintering) additive technology. The surfaces of titanium specimens have been subjected to the shot peening process by means of three different shots, i.e., CrNi steel shot, crushed nut shells, and ceramic balls shot. Then, the specimens have been subjected to profilometric analysis, microhardness tests, and static strength testing as well as to the assessment of biocompatibility in respect of cytotoxicity using human BJ fibroblasts. The shot peening process causes the strengthening of surface layer and the increase of strength parameters. Furthermore, the test results indicate good biocompatibility of surfaces being tested, and the effect of shot peening process on the titanium alloy cytotoxicity is acceptable. At the same time, most favourable behaviour in respect of cytotoxicity has been found in the case of surfaces modified by means of ceramic balls > nut shells > CrNi steel shot correspondingly.

Occurrence of BK Virus and Human Papilloma Virus in colorectal cancer.

INTRODUCTION AND OBJECTIVE: Colorectal cancer is one of the most common cancers worldwide. In Poland, it is the second most common cancer, regardless of gender. The aim of study was to analyze the incidence of HPV and BKV in the tissue of colorectal cancer and to determine the relationship between the presence of these viruses and the development of this cancer. MATERIAL AND METHODS: The experiments were conducted using 50 colorectal cancer tissues collected from histological sections. The clinical material was embedded in paraffin blocks. Next, DNA extraction was performed. Isolates of colorectal cancer tissue were tested for the presence of HPV DNA. BKV DNA was detected by PCR using specific primers and then differentiated from JCV by digestion with BamHI enzyme. RESULTS: In clinical specimens taken from patients with colorectal cancer, HPV DNA was detected in 20% of cases. In 10% of cases the presence of HPV type 18 was confirmed, in the other 90% of the samples HPV type 16 was detected, while the presence of BKV was confirmed in 30% of cases. Coinfection with HPV and BKV was shown in 12% of patients. In one case, BK virus coexisted with HPV type 18, in the remaining 5 cases with HPV type 16. CONCLUSIONS: Developing colorectal cancer can show no symptoms, even for many years. This is why it is so important to become familiar with as many etiological factors as possible. The development of many human neoplasms is often initiated by exposure to infectious agents - such as bacterial or viral infections. Similar to the human papillomavirus, the BK virus was detected in clinical specimens. It seems that HPV and BKV infections can contribute to the neoplastic process, which requires detailed studies on a larger group of patients.

Diagnostic Power of Blood Parameters as Screening Markers in Gastric Cancer Patients.

BACKGROUND: Gastric cancer (GC) is the fifth most common cancer worldwide. Since development is usually asymptomatic, it is generally diagnosed at an advanced stage. The value of screening in patients with nonspecific symptoms for GC is controversial. AIM: The study aimed to evaluate whether hematological parameters (platelet count (PC), mean platelet volume (MPV), MPV/PC ratio, red blood cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR)) are useful markers to differentiate between gastric cancer patients and healthy individuals. MATERIALS AND METHODS: Sixty-one patients with gastric cancer and sixty-one healthy individuals were enrolled to the survey and a retrospective analysis of selected blood parameters was performed. RESULTS: The mean values of PC, MPV, RDW, NLR, and PLR were significantly higher in GC patients compared to the control group. No statistical differences were observed in MPV/PC ratios. Likewise, no significant statistical differences were revealed in values of blood parameters among TNM stage groups. The RDW showed the highest diagnostic specificity and sensitivity. CONCLUSIONS: Hematological parameters: PC, MPV, RDW, NLR, PLR have diagnostic power and can discriminate patients with gastric cancer from patients without cancer. Blood parameters compared with clinical symptoms might alert physicians and patients and lead to performancce of upper gastrointestinal endoscopy, the gold standard in gastric cancer screening and thereby increase the early detection of cancer.