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Exp Toxicol Pathol ; 65(1-2): 61-7, 2013 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-21726989

RESUMEN

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a representative of a large group of polyhalogenated aromatic hydrocarbons that are widespread environmental contaminants. Administration of TCDD to laboratory animals or cultured cells results in a number of adverse effects that are well documented. For example, the effects of TCDD observed in developing organisms indicate that exposure to this class of environmental contaminants significantly alters embryo morphogenesis. However, it is not clear whether tissue regeneration in adult animals may be similarly affected. With this in mind, we examined the impact of TCDD exposure on wound healing using a murine cutaneous wound healing model. Our results indicate that TCDD exposure did not significantly alter the time needed for wound closure. However, in the TCDD-treated mice, a significant decrease in tensile strength in the healed wounds was observed which is indicative of an aberrantly healed wound. Immunostaining revealed that exposure to TCDD increased the population of macrophages detected within the wounded tissue at the latter stages of wound healing. Our findings support the idea that exposure to environmental contaminants such as TCDD is proinflammatory in the wounded tissue, disrupts normal healing and ultimately produces in a poorly healed wound.


Asunto(s)
Contaminantes Ambientales/toxicidad , Dibenzodioxinas Policloradas/toxicidad , Piel/efectos de los fármacos , Cicatrización de Heridas/efectos de los fármacos , Animales , Western Blotting , Proliferación Celular/efectos de los fármacos , Citocromo P-450 CYP1A1/biosíntesis , Femenino , Inmunohistoquímica , Queratinocitos/efectos de los fármacos , Queratinocitos/patología , Ratones , Ratones Endogámicos C57BL , Piel/enzimología , Piel/lesiones , Piel/patología , Resistencia a la Tracción , Factores de Tiempo
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