Levels of serum inflammatory cytokines and their correlations with disease severity in patients with chronic spontaneous urticaria.

Introduction: Inflammation is crucial in the pathogenesis of chronic spontaneous urticaria (CSU). Investigating the correlation between levels of serum inflammatory cytokines (SICs) and the severity of CSU is of great significance for understanding the disease mechanism and finding effective treatment strategies. Aim: In this context, this work was developed. Material and methods: This work involved a researchy group (Res group) of 114 patients with CSU and a control group (Ctrl group) of 100 healthy individuals. SICs including leukotriene B4 (LTB4), leukotriene C4 (LTC4), interleukin (IL) 4 (IL-4), IL-17, IL-31, and tumor necrosis factor-γ (TNF-γ), of patients in different groups were measured and compared. Furthermore, the correlations between each SIC and pruritus severity, duration of pruritus, urticaria activity, and quality of life (QOL) were compared among the patients in different groups. Results: The Res group exhibited higher levels of LTB4, LTC4, IL-4, IL-17, and IL-31 but lower levels of TNF-γ. Great differences (p < 0.05) were found in IL-4, IL-17, and IL-31 among the patients with different pruritus severity, and positive correlations were observed between IL-17 and IL-31 levels and urticaria activity in the patients (p < 0.05). Additionally, levels of IL-4 and IL-31 exhibited a positive association to QOL scores in the patients, with obvious differences (p < 0.05). Conclusions: IL-4, IL-17, and IL-31 showed the strongest correlation with the severity of CSU, which may be attributed to their involvement in immune, inflammatory, and pruritic reactions, exacerbating the disease condition.

Vector Angular Continuity in the Fusion of Coseismic Deformations at Multiple Optical Correlation Scales.

As one of the common techniques for measuring coseismic deformations, optical image correlation techniques are capable of overcoming the drawbacks of inadequate coherence and phase blurring which can occur in radar interferometry, as well as the problem of low spatial resolution in radar pixel offset tracking. However, the scales of the correlation window in optical image correlation techniques typically influence the results; the conventional SAR POT method faces a fundamental trade-off between the accuracy of matching and the preservation of details in the correlation window size. This study regards coseismic deformation as a two-dimensional vector, and develops a new post-processing workflow called VACI-OIC to reduce the dependence of shift estimation on the size of the correlation window. This paper takes the coseismic deformations in both the east-west and north-south directions into account at the same time, treating them as vectors, while also considering the similarity of displacement between adjacent points on the surface. Herein, the angular continuity index of the coseismic deformation vector was proposed as a more reasonable constraint condition to fuse the deformation field results obtained by optical image correlation across different correlation window. Taking the earthquake of 2021 in Maduo, China, as the study area, the deformation with the highest spatial resolution in the violent surface rupture area was determined (which could not be provided by SAR data). Compared to the results of single-scale optical correlation, the presented results were more uniform (i.e., more consistent with published results). At the same time, the proposed index also detected the strip fracture zone of the earthquake with impressive clarity.

Electrochemical Stability Investigations and Drug Toxicity Tests of Electrolyte-Gated Organic Field-Effect Transistors.

Electrolyte-gated organic field-effect transistors (EGOFETs) are emerging as a new frontier of organic bioelectronics, with promising applications in biosensing, pharmaceutical testing, and neuroscience. However, the limited charge carriers' mobility and well-known environmental instability of conjugated polymers constrain the real applications of organic bioelectronics. Here, we comparatively studied the electrochemical stability of p-type conjugated polymer films in the EGOFET configuration. By combining electrochemical stability tests, morphology characterization, and EQCM-D monitoring, we find that a donor-acceptor copolymer, poly(N-alkyldiketopyrrolo-pyrrole-dithienylthieno[3,2-b]thiophene) (DPP-DTT) shows improved mobility and electrochemical stability under an electrolyte, which may benefit from the ordered morphology and close alkyl side-chains' interdigitation preventing water diffusion and ion doping during long-term operation under an electrolyte. Based on the DPP-DTT EGOFETs, we have demonstrated a low-cost drug toxicity test platform that is sensitive enough to distinguish the cytotoxicity of different chemicals. This study overall pushes forward the development of organic bioelectronics with enhanced stability and sensitivity and presents successful exploitation of EGOFET in pharmaceutical research.

A Three-Hierarchy Evaluation of Polarimetric Performance of GF-3, Compared with ALOS-2/PALSAR-2 and RADARSAT-2.

GaoFen-3 (GF-3) is the first Chinese civilian multi-polarization synthetic aperture radar (SAR) satellite, launched on 10 August of 2016, and put into operation at the end of January 2017. The polarimetric SAR (PolSAR) system of GF-3 is able to provide quad-polarization (quad-pol) images in a variety of geophysical research and applications. However, this ability increases the complexity of maintaining image quality and calibration. As a result, to evaluate the quality of polarimetric data, polarimetric signatures are necessary to guarantee accuracy. Compared with some other operational space-borne PolSAR systems, such as ALOS-2/PALSAR-2 (ALOS-2) and RADARSAT-2, GF-3 has less reported calibration and image quality files, forcing users to validate the quality of polarimetric imagery of GF-3 before quantitative applications. In this study, without the validation data obtained from a calibration infrastructure, an innovative, three-hierarchy strategy was proposed to assess PolSAR data quality, in which the performance of GF-3 data was evaluated with ALOS-2 and RADARSAT-2 data as references. Experimental results suggested that: (1) PolSAR data of GF-3 satisfied backscatter reciprocity, similar with that of RADARSAT-2; (2) most of the GF-3 PolSAR images had no signs of polarimetric distortion affecting decomposition, and the system of GF-3 may have been improved around May 2017; and (3) the classification accuracy of GF-3 varied from 75.0% to 91.4% because of changing image-acquiring situations. In conclusion, the proposed three-hierarchy approach has the ability to evaluate polarimetric performance. It proved that the residual polarimetric distortion of calibrated GF-3 PolSAR data remained at an insignificant level, with reference to that of ALOS-2 and RADARSAT-2, and imposed no significant impact on the polarimetric decomposition components and classification accuracy.