A comprehensive analysis of GAS2 family members identifies that GAS2L1 is a novel biomarker and promotes the proliferation of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a common primary liver cancer with a high incidence and mortality. Members of the growth-arresting-specific 2 (GAS2) family are involved in various biological processes in human malignancies. To date, there is only a limited amount of information available about the expression profile and clinical importance of GAS2 family in HCC. In this study, we found that GAS2L1 and GAS2L3 were distinctly upregulated in HCC specimens compared to non-tumor specimens. Pan-cancer assays indicated that GAS2L1 and GAS2L3 were highly expressed in most cancers. The Pearson's correlation revealed that the expressions of GAS2, GAS2L1 and GAS2L2 were negatively associated with methylation levels. Survival assays indicated that GAS2L1 and GAS2L3 were independent prognostic factors for HCC patients. Immune cell infiltration analysis revealed that GAS2, GAS2L1 and GAS2L3 were associated with several immune cells. Finally, we confirmed that GAS2L1 was highly expressed in HCC cells and its knockdown suppressed the proliferation of HCC cells. Taken together, our findings suggested the expression patterns and prognostic values of GAS2 members in HCC, providing insights for further study of the GAS2 family as sensitive diagnostic and prognostic markers for HCC.

Accurately recognizing chromium species with multi-functionalized nano Au-based sensor array.

High-resolution identification of chromium (Cr) species, especially various organic-Cr complexes, in a convenient and economically-feasible manner is the prerequisite for achieving the advanced treatment of chromium wastewater. To this end, a colorimetric nano-Au sensor array was developed by taking advantage of the UV-spectra shift of gold nanoparticles (Au NPs) upon interaction with Cr species; specifically, four molecular modifiers [i.e., iminodiacetic acid (IDA), tripolyphosphate (TPP), cetyltrimethylammonium bromide (CTAB), and 1,5-diphenylcarbazide (DPC)] were intentionally employed for assembling nano-Au array receptors, which showed respective responses toward different Cr species through the formation of coordination, hydrophobic interaction, electrostatic attraction, and redox reaction, respectively; the "fingerprint" differences of the unique optical properties were then integrated for semi-quantitatively recognizing Cr species by pattern recognition techniques. Eleven ubiquitous Cr species [i.e., Cr(III), Cr(VI), and various Cr(III)-organic complexes] served as the model samples, which could be sensitively identified, no matter in individual or mixture mode, by the developed nano-Au sensor array on the basis of the colorimetric responses resulted from diverse nano-Au-aggregation behaviors, with excellent anti-interference ability in the simulated or actual water scenario. Attractively, the nano-Au sensor array can achieve very sensitive detection limit of the quantitative analyses of Cr species in a prompt in-situ manner, which usually requires a two-step process of separation and detection for the conventional analytical methods. Such a convenient strategy of Cr species discrimination conduces to rationally designing specific protocols for the advanced treatment of chromium wastewater.

Few-Layer Meets Crystalline Structure: Collaborative Efforts for Improving Photocatalytic H2O2 Generation over Carbon Nitride.

Although the conversion of O2 and H2O to H2O2 over graphite carbon nitride (g-C3N4) has been realized by means of the photocatalytic process, the catalytic activity of pristine g-C3N4 is still restricted by the rapid charge recombination and inadequate exposure of the active site. In this work, we propose a straightforward strategy to solve these limitations by decreasing the thickness and improving the crystallinity of g-C3N4, resulting in the preparation of few-layered crystalline carbon nitride (FL-CCN). Benefiting from the minimal thickness and highly ordered in-plane triangular cavities within the structure, FL-CCN processes an extended π-conjugated system with a reduced charge transfer resistance and expanded specific surface area. These features accelerate the efficiency of photogenerated charge separation in FL-CCN and contribute to explore of its surface active sites. Consequently, FL-CCN exhibits a significantly improved H2O2 evolution rate (63.95 µmol g-1 h-1), which is 7.8 times higher than that of pristine g-C3N4 (8.15 µmol g-1 h-1), during the photocatalytic conversion of O2 and H2O. This systematic investigation offers valuable insights into the mechanism of photocatalytic H2O2 generation and the development of efficient catalysts.

Organic cocatalysts improved Fenton and Fenton-like processes for water pollution control: A review.

In recent times, organic compounds have been extensively utilized to mitigate the limitations associated with Fe(Ⅲ) reduction and the narrow pH range in Fenton and Fenton-like processes, which have garnered considerable attention in relevant studies. This review presents the latest advancements in the comprehensive analysis and applications of organic agents as assistant/cocatalysts during Fenton/Fenton-like reactions for water pollution control. The primary focus includes the following: Firstly, the mechanism of organic co-catalytic reactions is introduced, encompassing both complexation and reduction aspects. Secondly, these organic compounds are classified into distinct categories based on their functional group structures and applications, namely polycarboxylates, aminopolycarboxylic acids, quinones, phenolic acids, humic substances, and sulfhydryl compounds, and their co-catalytic functions and mechanisms of each category are discussed in meticulous detail. Thirdly, a comprehensive comparison is conducted among various types of organic cocatalysts, considering their relative merits, cost implications, toxicity, and other pertinent factors. Finally, the review concludes by addressing the universal challenges and development prospects associated with organic co-catalytic systems. The overarching objective of this review is to provide insights into potential avenues for the future advancement of organic co-catalytic Fenton/Fenton-like reactions in the context of water purification.

Efficient photoelectrocatalytic degradation of pollutants over hydrophobic carbon felt loaded with Fe-doped porous carbon nitride via direct activation of molecular oxygen.

Developing a photoelectric cathode capable of efficiently activating molecular oxygen to degrade pollutants is a coveted yet challenging goal. In pursuit of this, we synthesize a Fe doped porous carbon nitride catalyst (Fe-CN) using an ionothermal strategy and subsequently loaded it on the hydrophobic carbon felt (CF) to fabricate the Fe-CN/CF photoelectric cathode. This cathode benefits from the synergistic effects between the porous CN support and the highly dispersed Fe species, which enhance O2 absorption and activation. Additionally, the hydrophobic CF serves as a gas diffusion layer, accelerating O2 mass transfer. These features enable the Fe-CN/CF cathode to demonstrate notable photoelectrocatalytic (PEC) degradation efficiency. Specifically, under optimal conditions (cathodic bias of -0.3 VAg/AgCl, pH 7, and a catalyst loading of 3 mg/cm2), the system achieves a 76.4% removal rate of tetracycline (TC) within 60 min. The general application potential of this system is further underscored by its ability to remove approximately 98% of 4-chlorophenol (4-CP) and phenol under identical conditions. Subsequent investigations into the active species and degradation pathways reveal that 1O2 and h+ play dominant role during the PEC degradation process, leading to gradually breakdown of TC into less toxicity, smaller molecular intermediates. This work presents a straightforward yet effective strategy for constructing efficient PEC systems that leverage molecular oxygen activation to degrade pollutants.

Efficient Removal and Recovery of Ag from Wastewater Using Charged Polystyrene-Polydopamine Nanocoatings and Their Sustainable Catalytic Application in 4-Nitrophenol Reduction.

This study addresses the long-standing challenges of removing and recovering trace silver (Ag) ions from wastewater while promoting their sustainable catalysis utilization. We innovatively developed a composite material by combining charged sulfonated polystyrene (PS) with a PDA coating. This composite serves a dual purpose: effectively removing and recovering trace Ag+ from wastewater and enabling reused Ag for sustainable applications, particularly in the catalytic reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP). The PS-PDA demonstrated exceptional selectivity to trace Ag+ recycling, which is equal to 14 times greater than the commercial ion exchanger. We emphasize the distinct roles of different charged functional groups in Ag+ removal and catalytic reduction performance. The negatively charged SO3H groups exhibited the remarkable ability to rapidly enrich trace Ag ions from wastewater, with a capacity 2-3 times higher than that of positively-N+(CH3)3Cl and netural-CH2Cl-modified composites; this resulted in an impressive 96% conversion of 4-NP to 4-AP within just 25 min. The fixed-bed application further confirmed the effective treatment capacity of approximately 4400 L of water per kilogram of adsorbent, while maintaining an extremely low effluent Ag+ concentration of less than 0.1 mg/L. XPS investigations provided valuable insights into the conversion of Ag+ ions into metallic Ag through the enticement of negatively charged SO3H groups and the in situ reduction facilitated by PDA. This breakthrough not only facilitates the efficient extraction of Ag from wastewater but also paves the way for its environmentally responsible utilization in catalytic reactions.

Electrically enhanced adsorption efficiency of aluminum nitride nanotube for sulfate ion removal from water.

Herein, the adsorption performance of sulfate ion in water on aluminum nitride nanotube(AlNNT) under the influence of an electric field was investigated using the density functional theory (DFT) calculation method. The model structure stability, adsorption energy, electronic and thermodynamic properties of sulfate ion adsorbed on the surface of AlNNT were studied. The calculation results indicate that sulfate ion reacts with multi-atoms on the surface of AlNNT, forming ionic bonds and undergoing chemical adsorption. As the electric field intensity increases, the adsorption energy and the transfer of electrons from sulfate ion to AlNNT increase, leading to a higher degree of hybridization of atomic orbitals and enhanced multi-atom interactions. Additionally, the thermodynamic data suggests that the adsorption between sulfate ion and AlNNT under electric field can occur spontaneously, the process of which is exothermic. The results of present study are expected to propose a novel method for separation and removal of sulfate pollutants from water.

A Sodiophilic Amyloid Fibril Modified Separator for Dendrite-Free Sodium-Metal Batteries.

Sodium (Na) batteries are being considered as prospective candidates for the next generation of secondary batteries in contrast to lithium-based batteries, due to their high raw-material abundance, low cost, and sustainability. However, the unfavorable growth of Na-metal deposition and severe interfacial reactions have prevented their large-scale applications. Here, a vacuum filtration strategy, through amyloid-fibril-modified glass-fiber separators, is proposed to address these issues. The modified symmetric cell can be cycled for 1800 h, surpassing the performance of previously reported Na-based electrodes under an ester-based electrolyte. Moreover, the Na/Na3 V2 (PO4 )3 full cell with a sodiophilic amyloid-fibril-modified separator exhibits a capacity retention of 87.13% even after 1000 cycles. Both the experimental and the theoretical results show that the sodiophilic amyloid fibril homogenizes the electric field and Na-ion concentration, fundamentally inhibiting dendrite formation. Simultaneously, the glutamine amino acids in the amyloid fibril have the highest adsorption energy for Na, resulting in the formation of a stable Na3 N- and NaNx Oy -rich solid-electrolyte-interface film on the anode during cycling. This work provides not only a possible pathway to solve the dendrite problem in metal batteries using environmentally friendly biomacromolecular materials, but also a new direction for expanding biomaterial applications.

EASpace: Enhanced Action Space for Policy Transfer.

Formulating expert policies as macro actions promises to alleviate the long-horizon issue via structured exploration and efficient credit assignment. However, traditional option-based multipolicy transfer methods suffer from inefficient exploration of macro action's length and insufficient exploitation of useful long-duration macro actions. In this article, a novel algorithm named enhanced action space (EASpace) is proposed, which formulates macro actions in an alternative form to accelerate the learning process using multiple available suboptimal expert policies. Specifically, EASpace formulates each expert policy into multiple macro actions with different execution times. All the macro actions are then integrated into the primitive action space directly. An intrinsic reward, which is proportional to the execution time of macro actions, is introduced to encourage the exploitation of useful macro actions. The corresponding learning rule that is similar to intraoption Q-learning is employed to improve the data efficiency. Theoretical analysis is presented to show the convergence of the proposed learning rule. The efficiency of EASpace is illustrated by a grid-based game and a multiagent pursuit problem. The proposed algorithm is also implemented in physical systems to validate its effectiveness.

Influence of an External Electric Field on Electronic and Optical Properties of a g-C3N4/TiO2 Heterostructure: A First-Principles Perspective.

In this study, calculations based on density functional theory (DFT) were utilized to examine how electrostatic fields affect the electrical and optical characteristics of g-C3N4/TiO2 heterostructures. The binding energy, density of states, difference in charge density, and optical absorption spectra of the heterostructure were calculated and analyzed to reveal the mechanism of the influence of the external electric field (EF) on the properties of the heterostructure. The results show that the binding energy of the heterogeneous structure is reduced due to the imposed electric field in X- and Y-directions, and the optical absorption spectrum is slightly enhanced, but the BG and charge transfer number are basically unchanged. On the contrary, applying the electric field in the Z-direction increases the binding energy of the heterogeneous structure, decreases the BG, increases the number of charge transfers, and red shifts the optical absorption spectrum, which improves the photocatalytic ability of the g-C3N4/TiO2 heterostructure.

Promoted elimination of metronidazole in ferrous ions activated peroxydisulfate process by gallic acid complexation.

We applied gallic acid (GA) as the complexing agent to stabilizing the regeneration of Fe2+ during the Fe2+/peroxydisulfate (PDS) Fenton-like reaction for promoting the removal of metronidazole (MTZ). This research evaluated the elimination of MTZ by optimizing the dose of GA and Fe2+ and pH condition. MTZ removal reached 83% at the GA: Fe2+ molar ratio of 1:1 (30 µM) and initial pH 5 and 6.2 after 120 min, and the kinetics showed two degradation phases (kobs1 = 0.09636 for the rapid stage and kobs2 = 0.01056 for the slow stage). The Fe2+ and GA complexes could expand the range of pH applicability and effectively stabilize the regeneration of Fe2+, which ultimately promoted the decontamination of MTZ. Sulfate radical (SO4.-), hydroxyl radicals, and singlet oxygen were proved to exist in this ternary system and contribute to MTZ removal, and SO4.- played the dominant role. Furthermore, the possible pathways and mechanisms for MTZ degradation were proposed, and the simulation result indicated that the toxicity of degradation intermediates of MTZ were declined. The GA assisted Fe2+/PDS system provided an improved promising advanced oxidation process for organic wastewater disposal.

Well-designed protein amyloid nanofibrils composites as versatile and sustainable materials for aquatic environment remediation: A review.

Amyloid nanofibrils (ANFs) are supramolecular polymers originally classified as pathological markers in various human degenerative diseases. However, in recent years, ANFs have garnered greater interest and are regarded as nature-based sustainable biomaterials in environmental science, material engineering, and nanotechnology. On a laboratory scale, ANFs can be produced from food proteins via protein unfolding, misfolding, and hydrolysis. Furthermore, ANFs have specific structural characteristics such as a high aspect ratio, good rigidity, chemical stability, and a controllable sequence. These properties make them a promising functional material in water decontamination research. As a result, the fabrication and application of ANFs and their composites in water purification have recently gained considerable attention. Despite the large amount of literature in this field, there is a lack of systematic review to assess the gap in using ANFs and their composites to remove contaminants from water. This review discusses significant advancements in design techniques as well as the physicochemical properties of ANFs-based composites. We also emphasize the current progress in using ANFs-based composites to remove inorganic, organic, and biological contaminants. The interaction mechanisms between ANFs-based composites and contaminants are also highlighted. Finally, we illustrate the challenges and opportunities associated with the future preparation and application of ANFs-based composites. We anticipate that this review will shed new light on the future design and use of ANFs-based composites.

Atypical Whipple's disease with special endoscopic manifestations: A case report.

BACKGROUND: Whipple's disease is a rare systemic infection caused by Tropheryma whipplei. Most patients present with nonspecific symptoms, and routine laboratory and imaging examination results also lack specificity. The diagnosis often relies on invasive manipulation, pathological examination, and molecular techniques. These difficulties in diagnosing Whipple's disease often result in misdiagnosis and inappropriate treatments. CASE SUMMARY: This paper reports on the case of a 58-year-old male patient who complained of fatigue and decreased exercise capacity. The results of routine blood tests indicated hypochromic microcytic anemia. Results of gastroscopy and capsule endoscopy showed multiple polypoid bulges distributed in the duodenal and proximal jejunum. A diagnosis of small intestinal adenomatosis was initially considered; hence, the Whipple procedure, a pylorus-preserving pancreaticoduodenectomy, was performed. Pathological manifestations showed many periodic acid-Schiff-positive macrophages aggregated in the intestinal mucosa of the duodenum, upper jejunum, and surrounding lymph nodes. Based on comprehensive analysis of symptoms, laboratory findings, and pathological manifestations, the patient was finally diagnosed with Whipple's disease. After receiving 1 mo of antibiotic treatment, the fatigue and anemia were significantly improved. CONCLUSION: This case presented with atypical gastrointestinal manifestations and small intestinal polypoid bulges, which provided new insight on the diagnosis of Whipple's disease.

Acteoside alleviates dextran sulphate sodium­induced ulcerative colitis via regulation of the HO­1/HMGB1 signaling pathway.

Ulcerative colitis (UC) is a significant burden on human health, and the elucidation of the mechanism by which it develops has potential for the prevention and treatment of UC. It has been reported that acteoside (ACT) exhibits strong anti­inflammatory activity. In the present study, it was hypothesized that ACT may exert a protective effect against UC. The effects of ACT on inflammation, oxidative stress and apoptosis were evaluated using dextran sulphate sodium (DSS)­treated mice and DSS­treated human colorectal adenocarcinoma Caco­2 cells, which have an epithelial morphology. The results demonstrated that the ACT­treated mice with DSS­induced UC exhibited significantly reduced colon inflammation, as demonstrated by a reversal in body weight loss, colon shortening, disease activity index score, inflammation, oxidative stress and colonic barrier dysfunction. Further in vivo experiments demonstrated that ACT inhibited DSS­induced apoptosis in colon tissues, as demonstrated by the results of the TUNEL assay and the altered protein expression levels of Bax, cleaved caspase­3 and Bcl­2. Furthermore, DSS significantly stimulated the protein expression levels of high mobility group box 1 protein (HMGB1), which serves a central role in the initiation and progression of UC, an effect which was markedly inhibited by ACT. Finally, DSS significantly decreased the protein expression levels of heme oxygenase­1 (HO­1) in colon tissues and the effect of ACT on GSH, apoptotic proteins and HMGB1 was markedly attenuated in the presence of the HO­1 inhibitor tin protoporphyrin. In conclusion, ACT ameliorated colon inflammation through HMGB1 inhibition in a HO­1­dependent manner.

Efficient visible-light-driven degradation of tetracycline by a 2D/2D rGO-Bi2WO6 heterostructure.

Constructing heterostructures has been a simple yet effective strategy for improving the photocatalytic performance of individual semiconductor photocatalysts. However, the poor quality of the contacted interface coupled with the narrow and overlapping light absorption scope between heterocomponents limits potential improvement. Herein, a 2D/2D rGO-Bi2WO6 heterostructure with face-to-face compact contact interface and UV to NIR light absorption ability was synthesized to overcome the aforementioned limitations. The as-prepared 2 wt%-rGO-Bi2WO6 with a high contact interface quality exhibits the highest kinetic rate of (5.53 ± 0.75) × 10-2 L mg-1 min-1 toward tetracycline (TC) degradation, which is 2.4 times higher than that of pristine Bi2WO6 and 2.1 times higher than that of the 2 wt%-rGO-Bi2WO6 composite with a poor interface quality. Moreover, approximately 30% of TC can be mineralized with a 2 wt%-rGO-Bi2WO6 presented system after 120 min. The subsequent Escherichia coli culture and liquid chromatography-mass spectrometry were employed to detect the biotoxicity variation of degradation intermediates and the possible transformation pathways of TC, respectively. Finally, the reactive species trapping results indicate that photogenerated holes and superoxide radical anions play dominant roles during the TC degradation process. This work provides a facile and effective method to fabricate an efficient heterojunction photocatalyst for pollutant degradation.

Efficient and sustainable phosphate removal from water by small-sized Al(OH)3 nanocrystals confined in discarded Artemia Cyst-shell: Ultrahigh sorption capacity and rapid sequestration.

We reported a new strategy for efficient phosphate removal from wastewaters, it relies on the discarded Artemia Cyst-shell in-situ growth of Al(OH)3 nanocluster, the charged amino-acids components of skeleton make available for the small size of Al(OH)3 formation (< 10 nm) with high activity, and the three-dimensional porous structure of discarded matrix provides fast kinetics and efficient Al(OH)3 nanoparticles utilization. These hybrid adsorbents exhibit ultrahigh capacity (850.5 mg/g) and fast kinetics (~2 min) by recent ten-years (2011-2020) survey, the superior selectivity against various foreign ions, with a distribution coefficient (Kd) as high as 4820 mL/g, the porous structure and fast kinetics also accelerate the phosphate accessibility, yielding a satisfactory capacity of ~3000 L/kg sorbent (Artemia CS-Al) for the application, even varying at high feeding-speeds. The saturated adsorbent can be readily regenerated and reused without decrease in performance, this technology is promising for mitigating the contamination problem of excess phosphate worldwide.

New insight into the bioinspired sub-10 nm Sn(HPO4)2 confinement for efficient heavy metal remediation in wastewater.

Heavy metal pollution poses a severe threat to the water environment. Engineering sub-10 nm active functional materials is an important approach to address the problems, and nanocomposites, developed in recent years by pore confinement always present weaken diffusion and low utilization of nanoparticles. In this study, we successfully prepared the polydopamine confined high-density sub-10 nm Sn(HPO4)2 coating for toxic lead(II) removal and its unique external coating structure and superior active sub-10 nm size achieved remarkable performances for heavy metal remediation. The hybrid sub-10 nm coating exhibits an extended acidic environment application (pH = 2.0-7.0) as well as significant selectivity with a superior Kd values (9.4 × 104 mL/g, which is 450 times greater than that of commercial sulfonated polystyrene. Ultrafast filtrations by vacuum further validate its superior sequestration (near to 100%) to Pb and Cd ions at different concentrations (10-100 mg/L) for 2 mins. The real column application further demonstrates the remarkable capacity of 11800 kg/kg sorbents, the trace effluents with three orders (∼103) reduction to below 1 ppb (> 99.9% Pb removal) and efficient stability for several cycles. The effective performances are mainly driven by the PDA motivated external nanoparticles arrangement and strong inner-sphere complexation by small size of Sn(HPO4)2. These results set a new benchmark for removing toxic metals and the proposed approach (engineering sub-10 nm coating design) is unique for heavy metal removal.

Self-Assembled Sandwich-like MXene-Derived Composites as Highly Efficient and Sustainable Catalysts for Wastewater Treatment.

Photocatalysts play an increasingly important role in environmental remediation polluted by industrial wastewater. However, the preparation of adsorbents and catalysts with high activity by simple and easy methods is still a great challenge. Here, sandwich-like composite catalyst Cu2O/TiO2/Ti3C2 was prepared by an easily available solvent reduction measure for the highly efficient catalytic nitro compounds. In particular, sandwich-like composite catalyst Cu2O/TiO2/Ti3C2 exhibits excellent catalysis for 2-nitroaniline (2-NA) and 4-nitrophenol (4-NP), and its pseudo-first-order reaction rate constants (k) are 0.163 and 0.114 min-1, respectively. Interestingly, even after eight consecutive cycles of catalytic experiments, the conversion rates of catalytic 2-NA and 4-NP are still greater than 95 and 92%, respectively, demonstrating that the obtained catalyst has excellent catalytic capability and a high reutilization rate. The excellent catalytic performances of Cu2O/TiO2/Ti3C2 can be attributed to the fact that Ti3C2 provides a greater reaction site for the formation of Cu2O and reduces the aggregation during the formation of Cu2O by in situ synthesis. Therefore, ternary composite catalyst Cu2O/TiO2/Ti3C2 prepared by solvent reduction not only supplies a technical method for the catalytic reaction of MXene-based material but also lays the foundation for the development of new photocatalysts.

Self-assembled functional components-doped conductive polypyrrole composite hydrogels with enhanced electrochemical performances.

A conductive hydrogel is a composite conductive material formed by combining a conductive polymer with a nanogel structure of a hydrogel. Conductive hydrogels not only have potential applications in supercapacitors, sensors, and modulators, they can also be synthesized by many methods, such as copolymerization, crosslinking, and grafting. In this work, we successfully prepared three conductive composite hydrogels by in situ polymerization, namely polypyrrole sodium alginate conductive hydrogel, ferric chloride-doped polypyrrole sodium alginate hydrogel and doped polypyrrole sodium alginate hydrogel with sodium dodecylbenzene sulfonate. In addition, a series of characterizations were performed for the three conductive hydrogels described above. The results show that the polypyrrole sodium alginate hydrogel doped with ferric chloride forms a nanofiber network with a more stable structure and better electrochemical performance.

Arsenate removal from underground water by polystyrene-confined hydrated ferric oxide (HFO) nanoparticles:effect of humic acid.

Arsenic decontamination from groundwater is an urgent but still challenging task. Polystyrene-based hydrated ferric oxide (denoted as D201-HFO) nanocomposite is a new emerging current adsorbent for efficient arsenate removal in natural waters; the resulting materials can interact with arsenate, mainly driven by inner complexation and static interaction and the existing HA effects on adsorption was well investigated. Results reveals that low concentrations of HA (below 25 mg/L) coexistence led to negligible effects on As(V) removal, but high levels of HA (100 mg/L) exerted outstanding sorption competition to As(V) removal; kinetics results revealed the HA additions brought about the diffusion prolonging and capacity decline, due to the large molecule structure of HA. Column experiments further showed the slight decrease application capacity of 810 BV by HA additions, with satisfactory saturation capacity; significantly, the presence of HA also exerted negligible influences on regeneration performances. All the sorbents with or without HA could be well regenerated by binary alkaline and salt mixture.