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Rotator cuff tear is a common injury among middle-aged and elderly people, and it has a great impact on patients' physical and mental health and quality of life. Integrative medicine based on Traditional Chinese Medicine (TCM) has certain advantages in the diagnosis and treatment of rotator cuff tears. TCM, which mainly involves the use of plant-based products, has relatively stable and reliable curative effects. It is of great significance to formulate a combined diagnosis and treatment plan for rotator cuff tear based on evidence-based medicine, which can help to standardize the clinical diagnosis and treatment techniques of TCM and Western medicine and achieve better therapeutic effects. This guideline standardizes the diagnosis and treatment process of rotator cuff tear from the aspects of range, terminology and definition, diagnosis, TCM syndrome differentiation, treatment, functional exercise, and prevention and care. It makes recommendations that cover the adoption of manual therapy, acupuncture, and other integrative medicine based on TCM. Users of these guidelines are most likely to include clinicians and health managers in healthcare settings.
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Medicina Tradicional China , Lesiones del Manguito de los Rotadores , Humanos , Lesiones del Manguito de los Rotadores/terapia , Lesiones del Manguito de los Rotadores/diagnóstico , Medicina Integrativa , Guías de Práctica Clínica como Asunto , Medicamentos Herbarios Chinos/uso terapéuticoRESUMEN
The study aims to analyze the feasibility of proposing waste cooking oil and industrial waste furfural residue as raw materials to prepare bio-asphalt as partial substitutes for petroleum asphalt, so as to reduce the cost of pavement construction and decrease the consumption of non-renewable resources. In this study, 90# petroleum asphalt was partially substituted with the bio-asphalt in different proportions to prepare biomass-modified petroleum asphalt, the performance of which was first evaluated based on three indices: penetration, softening point, and ductility. Comparison of the crystal structures of the bio-asphalt and furfural residue were enabled by X-ray diffraction, and the blending mechanism and microscopic morphologies of the biomass-substituted asphalt mixtures were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. The results showed that the bio-asphalt was hydrophobic and exhibited excellent compatibility with 90# petroleum asphalt. The partial substitution of petroleum asphalt with bio-asphalt improved the low-temperature crack resistance of the asphalt by adversely affecting the high-temperature stability of the asphalt; however, when the bio-asphalt content was 8 wt.%, the performance parameters of the biomass-modified asphalt met the requirements of the 90# petroleum asphalt standard.
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Robustness is an important property of image hashing. Most of the existing hashing algorithms do not reach good robustness against large-angle rotation. Aiming at this problem, we jointly exploit visual attention model and ring partition to design a novel image hashing, which can make good rotation robustness. In the proposed image hashing, a visual attention model called PFT (Phase spectrum of Fourier Transform) model is used to detect saliency map of preprocessed image. The LL sub-band of saliency map is then divided into concentric circles invariant to rotation by ring partition, and the means and variances of DWT coefficients on concentric circles are taken as image features. Next, these features are encrypted by a chaotic map and the Euclidean distances between normalized encrypted features are finally exploited to generate hash. Similarity between hashes is measured by L 1 norm. Many experimental tests show that our image hashing is robust to digital operations including rotation and reaches good discrimination. Comparisons demonstrate that classification performance of our image hashing outperforms those of some well-known hashing algorithms in terms of receiver operating characteristics curves. Simulation of image copy detection is carried out on an open image database called UCID and the result validates effectiveness of our hashing.
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Epithelialmesenchymal transition (EMT) is the process by which epithelial cells depolarize and acquire a mesenchymal phenotype, and is a common early step in the process of metastasis. Patients with lung cancer frequently already have distant metastases when they are diagnosed, highlighting the requirement for early and effective interventions to control metastatic disease. Transforming growth factorß1 (TGFß1) is able to induce EMT, however the molecular mechanism of this remains unclear. In the current study, TGFß1 was reported to induce EMT and promote the migration of nonsmall cell lung cancer (NSCLC) cells. A notable observation was that EMT induction was accompanied by the upregulation of human gliomaassociated oncogene homolog 1 (Gli1) mRNA and protein levels. Furthermore, Gli1 levels were depleted by small interfering RNA, and the Gli1 inhibitor GANT 61 attenuated the TGFß1mediated induction of EMT and cell migration. The results of the current study suggest that Gli1 regulates TGFß1induced EMT, which may provide a novel therapeutic target to inhibit metastasis in patients with NSCLC.
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Carcinoma de Pulmón de Células no Pequeñas/genética , Carcinoma de Pulmón de Células no Pequeñas/patología , Transición Epitelial-Mesenquimal/efectos de los fármacos , Transición Epitelial-Mesenquimal/genética , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/patología , Factores de Transcripción/genética , Factor de Crecimiento Transformador beta1/farmacología , Línea Celular Tumoral , Movimiento Celular/efectos de los fármacos , Movimiento Celular/genética , Regulación Neoplásica de la Expresión Génica/efectos de los fármacos , Humanos , Interferencia de ARN , ARN Interferente Pequeño/genética , Proteína con Dedos de Zinc GLI1RESUMEN
Squamous cell carcinoma and adenocarcinoma are the major histological types of non-small cell lung cancer. Because they differ on the basis of histopathological and clinical characteristics and their relationship with smoking, their etiologies may be different; for example, different tumor suppressor genes may be related to the genesis of each type. We used microarray data to construct three regulatory networks to identify potential genes related to lung adenocarcinoma and squamous cell carcinoma and investigated the similarity and specificity of them. In the network, some of the observed transcription factors and target genes had been previously proven to be related to lung adenocarcinoma and squamous cell carcinoma. We also found some new transcription factors and target genes related to SCC. The results demonstrated that regulatory network analysis is useful in connection analysis between lung adenocarcinoma and squamous cell carcinoma.
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Adenocarcinoma/genética , Carcinoma de Células Escamosas/genética , Redes Reguladoras de Genes , Neoplasias Pulmonares/genética , Perfilación de la Expresión Génica , Genes , Humanos , Análisis de Secuencia por Matrices de Oligonucleótidos , Factores de TranscripciónRESUMEN
Commercial activated carbon was treated by HNO3 oxidation and then subsequently heat treated under N2 atmosphere. Effect of surface chemical properties and pore structure on the adsorption performance of nitrobenzene was investigated. N2/77K adsorption isotherm and scanning electron microscopy (SEM) were used to characterize the pore structure and surface morphology of carbon. Boehm titration, Fourier transform infrared spectroscopy (FTIR), the point of zero charge (pH(PZC)) measurement and elemental analysis were used to characterize the surface properties. The results reveal that HNO3 oxidation can modify the surface chemical properties, increase the number of acidic surface oxygen-containing groups and has trivial effect on the pore structure of carbon. Further heat treatment can cause the decomposition of surface oxygen-containing groups, and increase the external surface area and the number of mesopores. Adsorption capacity of nitrobenzene on AC(NO-T), AC(raw) and AC(NO) was 1011.31, 483.09 and 321.54 mg x g(-1), respectively. Larger external surface area and the number of meso-pores, together with the less acid surface oxygen-containing groups were the main reason for the larger adsorption capacity AC(NO-T).