RESUMEN
OBJECTIVES: Lymphocytes can affect the proliferation and migration of muscle satellite cells, which may be associated with reduced muscle mass in patients with sarcopenia. The present study aimed to further enrich understandings of the changes of blood lymphocytes and explore the relationship between peripheral lymphocyte subsets and muscle mass in patients with sarcopenia. DESIGN: A cross-sectional study. SETTING: Geriatrics department of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. METHODS: Eighty-five subjects were enrolled in this study, and were divided into two groups: the sarcopenia group (n=60) and the non-sarcopenia group (n=25). The diagnosis of sarcopenia was based on the diagnostic criteria updated by the Asian Working Group for Sarcopenia (AWGS) in 2014. Complete blood count, peripheral lymphocyte subsets, and body composition of all patients were measured. RESULTS: Skeletal muscle mass index (SMI) was negatively correlated with CD4+CD28null T lymphocytes in peripheral blood in patients with sarcopenia. CONCLUSION: The result of our study may point out the role of CD4+CD28null T lymphocytes in the pathogenesis of sarcopenia.
Asunto(s)
Subgrupos Linfocitarios/metabolismo , Músculo Esquelético/fisiología , Sarcopenia/diagnóstico , China , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
Ultraconserved elements, sequences with 100% identity with no insertions or deletions between genomes, have been found in both vertebrate and invertebrate genomes; whether plant genomes contain ultraconserved elements, however, is unknown. We consequently compared the genomes of Arabidopsis thaliana and rice, which diverged about 200 million years ago, and identified 25 ultraconserved elements that are longer than 100 bp. Similar to those previously found, ultraconserved elements in plants tend to occur in clusters and locate at noncoding regions; nevertheless, they have many distinct features. For instance, the longest ultraconserved element between the 2 plant genomes is 1491 bp, much longer than the longest one (779 bp) between the human and rodent genomes. Some biological implications are discussed, but the functions of these plant ultraconserved elements and the reasons why they are practically frozen during the evolution of millions of years remain a mystery.
