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J Fluoresc ; 31(6): 1907-1916, 2021 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-34536169

RESUMEN

Two coordination polymers, that is [Zn(pdc)(im)(H2O)]n (1) and [Cu(pdc)(im)2]n·n(H2pdc) (2) (H2pdc = terephthalic acid, im = imidazole), were hydrothermally synthesized via the reactions of H2pdc and im in combination with Zn(II) or Cu(II) ions. Compound 1 shows intense blue luminescence and compound 2 shows good photocatalytic activity for the methyl violet degradation under the irradiation of ultraviolet light. In addition, the assessment of the two compounds' application values against Parkinson's disease were carried out and their specific mechanism was tested simultaneously. First of all, the real time RT-PCR was implemented and the relative expression levels of N-methyl-D-aspartic acid receptor receptor on neurons were measured. Besides, the Annexin V-FITC/PI apoptosis assay was utilized for the assessment of the influence of the compounds on the dopaminergic neuron death rate. The hemolysis toxicity detection was conducted to detect the biocompatible of the compounds.


Asunto(s)
Complejos de Coordinación/farmacología , Cobre/farmacología , Fármacos Neuroprotectores/farmacología , Enfermedad de Parkinson/prevención & control , Sustancias Protectoras/farmacología , Zinc/farmacología , Animales , Apoptosis/efectos de los fármacos , Catálisis , Complejos de Coordinación/síntesis química , Complejos de Coordinación/química , Cobre/química , Cristalografía por Rayos X , Violeta de Genciana/química , Luminiscencia , Ratones , Modelos Moleculares , Neuronas/efectos de los fármacos , Fármacos Neuroprotectores/síntesis química , Fármacos Neuroprotectores/química , Procesos Fotoquímicos , Sustancias Protectoras/síntesis química , Sustancias Protectoras/química , Conejos , Zinc/química
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