RESUMEN
Examining informal institutional drivers of corporate sustainability is crucial. This study employs a sample of A-share listed firms in China from 2007 to 2020 to empirically examine the relationship between media coverage and ESG performance. It is demonstrated that media attention enhances corporate accountability, especially the print media and positive attention. And environmental investments and green innovation are the main mechanisms. It also reveals that media attention has a greater impact on larger firms, those with better internal controls, firms located in the eastern region, and manufacturing firms. Our findings help deepen the understanding of media's role in corporate development and highlight how informal institutions can promote sustainable economic growth in developing countries.
RESUMEN
The high expression of programmed death 1 (PD-1) is a hallmark of T cell exhaustion, consequently inhibiting the anti-tumor immunity, tumor-associated macrophages (TAMs) aggravate Osteosarcoma (OS) progression. However, PD-1 expression on TAMs in OS metastasis remains unclear. Here, we used scRNA-Seq of 15500 individual cells from human OS lung metastatic lesion, identified thirteen major cell clusters. Our data revealed that tumor-infiltrating lymphocytes (TILs) OS lung metastatic accompanied by accumulation of exhausted T cells and regulatory T cells (Tregs). CD3+ T cells from human OS lung metastatic exhibited lower proliferation than in primary tissue. Importantly, TAMs mainly comprise immunosuppressive M2 phenotype in OS metastasis. Mechanistically, we found that PD-1 of TAMs inhibits the phagocytic potency, further promoting the progression of OS metastasis. Therefore, the study provides a strong technical support for OS immunotherapy based on PD-1 inhibitors.