Progress in research on the role of clinical nutrition in treating traumatic brain injury affecting the neurovascular unit.

The neurovascular unit (NVU) is composed of neurons, glial cells, and blood vessels. NVU dysfunction involves the processes of neuroinflammation, and microcirculatory disturbances, as well as neuronal injury after traumatic brain injury (TBI). Traditional anti-inflammatory drugs have limited efficacy in improving the prognosis of TBI. Thus, treatments that target NVU dysfunction may provide a breakthrough. A large number of clinical studies have shown that the nutritional status of patients with TBI was closely related to their conditions and prognoses. Nutrient complexes and complementary therapies for the treatment of TBI are therefore being implemented in many preclinical studies. Importantly, the mechanism of action for this treatment may be related to repair of NVU dysfunction by ensuring adequate omega-3 fatty acids, curcumin, resveratrol, apigenin, vitamins, and minerals. These nutritional supplements hold promise for translation to clinical therapy. In addition, dietary habits also play an important role in the rehabilitation of TBI. Poor dietary habits may worsen the pathology and prognosis of TBI. Adjusting dietary habits, especially with a ketogenic diet, may improve outcomes in patients with TBI. This article discusses the impact of clinical nutrition on NVU dysfunction after TBI, focusing on nutritional complexes and dietary habits.

[Effects of plant growth regulators on cutting propagation of Rosa laevigata].

OBJECTIVE: To explore the optimal plant growth regulator and its suitable concentration for the cutting propagation of Rosa laevigata. METHODS: The cuttings were dealt with 6 kinds of plant growth regulators (IAA,IBA, NAA, PP333, 2, 4-D and ABT) at different concentrations (100, 200 and 500 mg/L) for 50 seconds. After 30 days growth, by analysis of variance and multiple comparisons,the most suitable cutting propagation method for Rosa laevigata was found. RESULTS: Under the same condition, different concentration of different kinds of plant growth regulators had different effects on cutting propagation of Rosa laevigata. Generally speaking,cuttings soaked with 200 mg/L PP333 for 50 seconds was the best,with the high multiple effectiveness index and average root number (12.42); Cuttings soaked with 200 mg/L IBA for 50 seconds also had significant effects, with the second high multiple effectiveness index and the highest survival rate (96.67%). CONCLUSION: 200 mg/L PP333 can promote cutting propagation of Rosa laevigata best.