Altered EEG Microstates Dynamics in Individuals with Subthreshold Depression When Generating Negative Future Events.

Negative bias in prospection may play a crucial role in driving and maintaining depression. Recent research suggests abnormal activation and functional connectivity in regions of the default mode network (DMN) during future event generation in depressed individuals. However, the neural dynamics during prospection in these individuals remain unknown. To capture network dynamics at high temporal resolution, we employed electroencephalogram (EEG) microstate analysis. We examined microstate properties during both positive and negative prospection in 35 individuals with subthreshold depression (SD) and 35 controls. We identified similar sets of four canonical microstates (A-D) across groups and conditions. Source analysis indicated that each microstate map partially overlapped with a subsystem of the DMN (A: verbal; B: visual-spatial; C: self-referential; and D: modulation). Notably, alterations in EEG microstates were primarily observed in negative prospection of individuals with SD. Specifically, when generating negative future events, the coverage, occurrence, and duration of microstate A increased, while the coverage and duration of microstates B and D decreased in the SD group compared to controls. Furthermore, we observed altered transitions, particularly involving microstate C, during negative prospection in the SD group. These altered dynamics suggest dysconnectivity between subsystems of the DMN during negative prospection in individuals with SD. In conclusion, we provide novel insights into the neural mechanisms of negative bias in depression. These alterations could serve as specific markers for depression and potential targets for future interventions.

The development of the Negative Bias in Prospection Scale: A novel assessment of dysfunctional prospection in depression.

"Prospection" refers to the ability to mentally simulate one's future episodes. Negative bias in prospection, which includes both reduced positivity and enhanced negativity, is considered to be closely related to the development and maintenance of depression. However, there is a relative paucity of measures that adequately assess negative bias in prospection in depressed people. The current study developed and initially validated the Negative Bias in Prospection Scale (NBPS) using a nonclinical sample (n = 959). The validity and reliability of the NBPS were investigated in several ways. Results suggested the 14 NBPS items loaded onto three factors, namely the "Increased negativity," the "Reduced positivity," and the "Overgeneralization." The NBPS demonstrated decent internal consistency and test-retest reliability. Further, the NBPS was strongly associated with severity of depressive symptoms. Moreover, the NBPS was correlated in a theoretically meaningful way with other measures of future-oriented cognitions or negative biases. In conclusion, the NBPS has promising preliminary psychometric properties. It will be an efficient tool for exploring dysfunctional prospection in depression and provides a novel measure for mechanism of change in prospection-based interventions.

A chain multiple mediation model reveals the association between abuse and depression in Chinese adolescents.

Background: Depression is a common mental disorder in Chinese adolescents. Identifying its risk factors will facilitate early prevention. As abuse is reported to be a great risk factor of depression, it is necessary to identify factors mediating the relation between abuse and depression. Objective: This study aims to investigate the association between abuse and depression by investigating the mediating role of academic stress, social anxiety, and generalized anxiety to offer insights for depression prevention. Participants and setting: We investigated adolescents in urban and rural areas in Wansheng District of Chongqing city in China. This study included a total of 14,108 students from secondary and primary schools, among whom 7,086 were men (50.2%) and 7,022 were women (49.8%). The participants aged from 11 to 17 with an average age of 13.58 (M = 13.58, SD = 1.86). Methods: A questionnaire survey was conducted among the participants between October and December in 2020. The following questionnaires were adopted: DSM-5 Patient Health Questionnaire for Adolescents, DSM-5 Severity Measure for Generalized Anxiety Disorder, The International Society for Prevention of Child Abuse and Neglect Child Abuse Screening Tool, DSM-5 Severity Measure for Social Anxiety Disorder (Social Phobia), and Study Stress Scale. Results: The lifetime prevalence of abuse was high in Chinese adolescents. The direct effect value from abuse to depression was 0.05, the total mediating effect value was 0.14, and the overall effect value was 0.19. According to the mediating effect analysis, the direct and indirect effects from abuse to depression were significant, and the mediating effect accounted for 73.68% of the total effect, suggesting that 73.68% of the effects of abuse to depression are mediated by academic stress, social anxiety, and generalized anxiety. Conclusions: Academic stress, social anxiety and generalized anxiety play a chain multiple mediating role in the association between abuse and depression, which sheds light on the prevention of depression in the future.

The Relationships between Prospection, Self-Efficacy, and Depression in College Students with Cross-Lagged Analysis.

Depression is one of the most prevalent and disabling mental health problems in college students. Previous studies have established cross-sectional associations between negative bias in prospection e.g., increased negativity in future simulation, low self-efficacy, and depressive symptoms. Nevertheless, the temporal bidirectional associations between them are rarely examined. In the current study, we collected valid data on 276 college students at two time points within a 10 week interval. Cross-lagged panel analysis was applied to investigate the relationships between proportions of negative future events, levels of self-efficacy, and depressive symptoms. Results suggested depressive symptoms predict subsequent proportions of negative prospections and levels of self-efficacy. Inversely, neither prospection nor self-efficacy predicted depression. Temporal correlations between prospection and self-efficacy were also not significant. Since this is one of the first studies that attempts to figure out temporal links between these mutually informing factors, more longitudinal research is needed to draw a firm conclusion. This study provides new insights into the relationship between negative biases in cognitions and depressive symptoms and highlights the need to intervene early with depressive symptoms before any possible cognitive distortions in college students.

The Effect of Group Identification on Death Anxiety: The Chain Mediation Role of Close Relationships and Self-Esteem.

Based on the terror management theory (TMT), this study integrated self-esteem and close relationships to explore the effects of group identification on death anxiety. Five hundred and four participants completed the Death Anxiety, Rosenberg Self-Esteem, Social Identity, and Inclusion of Other in the Self scales via online platforms. There were significant correlations among group identification, close relationship, self-esteem, and death anxiety. Group identification had a significant negative predictive effect on death anxiety. Specifically, group identification affects death anxiety through two pathways: the separate mediating role of self-esteem and the serial mediation pathway of close relationships → self-esteem. Our study provides direct evidence that group identification relieves death anxiety. The results showed that the alleviating function of group identification was mediated by self-esteem and close relationships. This study provides a new perspective concerning TMT as a defense mechanism against death anxiety.

Self-Hierarchy in Perceptual Matching: Variations in Different Processing Stages.

People have three cognitive representations of the self, namely, the individual, relational, and collective selves (CS), which are indispensable components of selfhood but not necessarily given equal preference. Previous studies found that people displayed varied self-hierarchy in miscellaneous tasks involving different research materials that had pre-existing learned associations established over long periods of time. Therefore, this study tries to explore a purer self-hierarchy without the influence of research materials, using perceptual matching tasks. The behavioral and event-related potentials' (ERPs) findings showed that people recognized information association with their individual self (IS) faster compared with their relational (RS) and CS. Smaller N2, stronger P3 and late positive complex (LPC) amplitudes were evoked during IS compared with RS and CS. However, the three selves evoked equal P2 amplitudes at the early processing stage. Moreover, CS showed a weaker advantage than RS, demonstrating a longer reaction time, lower d prime, and weaker P3 and LPC amplitudes in the parietal region. Overall, self-hierarchy during simple perceptual processing manifested as IS > RS > CS at the late processing stage but manifested as IS = RS = CS at the early processing stage. Self-hierarchy varies according to the processing stage, even without meaningful information and during the simple perception processing. This result provides direct evidence that all selves can be tagged with neutral actions, which would fit the idea of an organism attuned to self-survival at multiple processing levels.

The Hierarchical Relationship Between the Relational-Self and the Collective-Self During Attention Processing.

Background: Under the Chinese collectivist cultural system, people emphasize social connections with close others and members of in-groups. Collectivism can be divided into the following two forms: relational collectivism (privileges relational self [RS]) and group collectivism (emphasizes collective self [CS]). Previous researchers have found a hierarchy between the RS and CS, resulting in different degrees of recognition advantages. However, the hierarchy between the RS and CS is unclear and may depend on the specific processing stage. Therefore, this research compared the hierarchy between these two selves during different processing stages using an eye-movement method. Methods: The sample consisted of thirty-eight young adults aged between 18 and 24 years old (M = 20.45, SD= 1.62). Each participant finished a dot-probe task featuring high-relevant (HR, ie one's mother's name and China) and low-relevant (LR, ie, name of a famous person and USA) information about the RS and CS and neutral information. Further, the eye-movement (EM) indices were collected simultaneously. Results: A stronger reaction time bias and longer total gaze duration revealed that young people in China focus more on RS information, indicating that Chinese people prioritize the RS over the CS at late stages of attentional processing. Conclusion: Information on interpersonal relationships and information on the in-group both catch people's attention quickly and easily, but only RS information can maintain attention for longer. Understanding the hierarchy of the RS and the CS may provide more evidence for self-construal in the Chinese collectivist cultural context. The importance of the RS prompting that the interpersonal and close relationships are more important to the development of the self, suggesting that it is necessary to pay more attention to the impact of interpersonal support on people's mental health in clinical applications.

The Neural Representation of Relational- and Collective-Self: Two Forms of Collectivism.

The collectivism can be divided into two forms: relational collectivism and group collectivism. According to the cognitive representation of self, relational collectivism emphasizes the relational-self and group collectivism privileges the collective-self. However, it remains uncertain whether there is a difference between relational-self and collective-self under Chinese collectivism cultural. To address the above issue, the present study examined the neural representation of relational-self and collective-self during trait judgment tasks using functional magnetic resonance imaging (fMRI). The results showed that relational-self-reference compared with collective-self-reference generated stronger medial prefrontal cortex (MPFC) activity, indicating relational-self was more closeness and important in the self-concept than collective-self under East Asian cultural background. Relational-self and collective-self are unequally represented in the MPFC, providing direct neural evidence that the collectivism in China can be divided into relational collectivism and group collectivism.