RESUMEN
Circadian rhythm is an internal regulatory mechanism formed in organisms in response to the circadian periodicity in the environment, which modulates the pathophysiological events, occurrence and development of diseases, and the response to treatment in mammals. It significantly influences the susceptibility, injury, and recovery of ischemic stroke, and the response to therapy. Accumulating evidence indicates that circadian rhythms not only regulate the important physiological factors of ischemic stroke events, such as blood pressure and coagulation-fibrinolysis system, but also participate in the immuno-inflammatory reaction mediated by glial cells and peripheral immune cells after ischemic injury and the regulation of neurovascular unit(NVU). This article aims to link molecular, cellular, and physiological pathways in circadian biology to the clinical consequences of ischemic stroke and to illustrate the impact of circadian rhythms on ischemic stroke pathogenesis, the regulation of NVU, and the immuno-inflammatory responses. The regulation of circadian rhythm by traditional Chinese medicine is reviewed, and the research progress of traditional Chinese medicine intervention in circadian rhythm is summarized to provide a reasonable and valuable reference for the follow-up traditional Chinese medicine research and molecular mechanism research of circadian rhythm.
Asunto(s)
Accidente Cerebrovascular Isquémico , Animales , Medicina Tradicional China , Ritmo Circadiano , Coagulación Sanguínea , Presión Sanguínea , MamíferosRESUMEN
OBJECTIVE: To study the effects of Compound Danshen Tablet (CDT) on the expression of the beta-amyloid peptide (Abeta) in transgenic cell model of Alzheimer's disease (AD). METHODS: The previously successfully cultured transgenic cell model was used as AD transgenic cell model. Rats were fed with 0.5, 1, 2, and 4 times CDT. The AD transgenic cells were cultured in 0.5, 1, 2, and 4 times rats' sera. The expressions of Abeta in transgenic cells were detected using Western blot. RESULTS: The optimal dose effect was obtained in the 1 time CDT group at 24 h. CONCLUSION: CDT could reduce the Abeta expression level in the AD transgenic cell model.
Asunto(s)
Enfermedad de Alzheimer/metabolismo , Péptidos beta-Amiloides/metabolismo , Medicamentos Herbarios Chinos/farmacología , Enfermedad de Alzheimer/genética , Animales , Línea Celular , Ratas , Ratas Sprague-Dawley , Salvia miltiorrhiza/química , TransgenesRESUMEN
In this paper, the theoretical and experimental researches concerning the prevention and treatment of myocardial ischemia/reperfusion (I/R) injury by Chinese medicine (CM) therapy of activating blood circulation and removing stasis in recent five years were reviewed, and the mechanisms were summarized. Thereby, based upon the current development of molecular biology and application of new technology, the authors offered their suggestions on the emphasized points and methods of present CM study in this scope.
