Study on the therapeutic effects and prognosis evaluation of non-invasive ventilation in patients with chronic obstructive pulmonary disease with lung cancer.

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory complication among the elderly, and its severity can escalate to respiratory failure as the disease progresses. OBJECTIVE: To evaluate the application value of non-invasive ventilation in the clinical treatment of patients with COPD and lung cancer. This study assesses its therapeutic effects and its impact on patients' quality of life (QoL) as measured by the Functional Assessment of Cancer Therapy-Lung (FACT-L) scale. METHODS: A retrospective analysis was conducted on clinical data from 102 patients with COPD and lung cancer. Patients were divided into two groups: the control group (n= 48), who received conventional treatment, and the observation group (n= 54), who received non-invasive positive pressure ventilation (NIPPV) in addition to conventional treatment. Relevant indicators of curative effect, including blood gas indices, incidence of dyspnoea, improvements in mental health and appetite, and FACT-L QoL scores, were analysed at 2 weeks, 1 month, and 6 months post-treatment. RESULTS: At 2 weeks post-treatment, the observation group who had used NIPPV showed significant improvements in blood gas indices, dyspnoea, mental state and self-care ability compared with the control group (p< 0.05). At 1 month, these benefits persisted and included improved maintenance of body weight (p< 0.05). By 6 months, the observation group had a lower incidence of pulmonary encephalopathy (p< 0.05), and QoL, as measured by the FACT-L scale, improved significantly in the observation group but declined in the control group (p< 0.05). CONCLUSION: NIPPV demonstrates significant efficacy in treating COPD patients with lung cancer, particularly in enhancing curative effects and improving patients' QoL.

A Linearly Polarized Wavelength-Tunable Q-Switched Fiber Laser with a Narrow Spectral Bandwidth of 112 MHz.

A tunable and narrow-bandwidth Q-switched ytterbium-doped fiber (YDF) laser is investigated in this paper. The non-pumped YDF acts as a saturable absorber and, together with a Sagnac loop mirror, provides a dynamic spectral-filtering grating to achieve a narrow-linewidth Q-switched output. By adjusting an etalon-based tunable fiber filter, a tunable wavelength from 1027 nm to 1033 nm is obtained. When the pump power is 1.75 W, the Q-switched laser pulses with a pulse energy of 10.45 nJ, and a repetition frequency of 11.98 kHz and spectral linewidth of 112 MHz are obtained. This work paves the way for the generation narrow-linewidth Q-switched lasers with tunable wavelengths in conventional ytterbium, erbium, and thulium fiber bands to address critical applications such as coherent detection, biomedicine, and nonlinear frequency conversion.

An Ingestible Pill With CMOS Fluorescence Sensor Array, Bi-Directional Wireless Interface and Packaged Optics for in-Vivo Bio-Molecular Sensing.

The article presents for the first time a pill-based ingestible electronics with CMOS integrated multiplexed fluorescence bio-molecular sensor arrays, bi-directional wireless communication and packaged optics in a FDA-approved capsule for in-vivo bio-molecular sensing. The silicon chip integrates both the sensor array, and the ultra-low-power (ULP) wireless system that allows offloading sensor computing to an external base station that can reconfigure the sensor measurement time, and its dynamic range, allowing optimized high sensitivity measurement under low power consumption. The integrated receiver achieves -59 dBm receiver sensitivity dissipating 121 µW of power. The integrated transmitter operates in a dual mode FSK/OOK delivering -15 dBm of power. The 15-pixel fluorescence sensor array follows an electronic-optic co-design methodology and integrates the nano-optical filters with integrated sub-wavelength metal layers that achieves high extinction ratio (39 dB), thereby eliminating the need for bulky external optical filters. The chip integrates photo-detection circuitry and on-chip 10-bit digitation, and achieves measured sensitivity of 1.6 attomoles of fluorescence labels on surface, and between 100 pM to 1 nM of target DNA detection limit per pixel. The complete package includes a CMOS fluorescent sensor chip with integrated filter, a prototyped UV LED and optical waveguide, functionalized bioslip, off-chip power management and Tx/Rx antenna that fits in a standard FDA approved capsule size 000.

Characterization of a Novel Artemisinin Algicidal Particle and Its Inhibitory Effect on Microcystis aeruginosa.

A new artemisinin sustained-release particle (ASP) was developed that significantly inhibits Microcystis aeruginosa (M. aeruginosa) growth. The physical and chemical properties of ASPs were characterized using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), differential scanning calorimetry, and thermogravimetry (DSC-TG). The results demonstrated that ASPs are thermally stable and have sustained-release properties. On the sixth day, the ASPs (0.2 g L-1) inhibited M. aeruginosa with an inhibition rate (IR) greater than 70%. Additionally, ASPs inhibited M. aeruginosa without increasing microcystin-LR release (MC-LR). This research offers a novel approach to the management of cyanobacterial blooms.

Topological laser with higher-order corner states in the 2-dimensional Su-Schrieffer-Heeger model.

A nonlinear non-Hermitian topological laser system based on the higher-order corner states of the 2-dimensional (2D) Su-Schrieffer-Heeger (SSH) model is investigated. The topological property of this nonlinear non-Hermitian system described by the quench dynamics is in accordance with that of a normal 2D SSH model. In the topological phase, all sites belonging to the topological corner states begin to emit stable laser light when a pulse is given to any one site of the lattice, while no laser light is emitted when the lattice is in the trivial phase. Furthermore, the next-nearest-neighbor (NNN) couplings are introduced into the strong-coupling unit cells of the 2D SSH model, which open a band gap in the continuous band structure. In the topological phase, similar to the case of 2D SSH model without NNN couplings, the corner sites can emit stable laser light due to the robustness of the higher-order corner states when the NNN couplings are regarded as the perturbation. However, amplitude of the stimulated site does not decay to zero in the trivial phase, because the existence of the NNN couplings in the strong-coupling unit cells make the lattice like one in the tetramer limit, and a weaker laser light is emitted by each corner.

An innovative strategy to control Microcystis growth using tea polyphenols sustained-release particles: preparation, characterization, and inhibition mechanism.

Allelochemicals have been shown to inhibit cyanobacterial blooms for several years. In view of the disadvantages of "direct-added" mode, natural and pollution-free tea polyphenolic allelochemicals with good inhibitory effect on cyanobacteria were selected to prepare sustained-release particles by microcapsule technology. Results showed that the encapsulation efficiency of tea polyphenols sustained-release particles (TPSPs) was 50.6% and the particle size ranged from 700 to 970 nm, which reached the nanoscale under optimum preparation condition. Physical and chemical properties of TPSPs were characterized to prove that tea polyphenols were well encapsulated and the particles had good thermal stability. The optimal dosage of TPSPs was determined to be 0.3 g/L, at which the inhibition rate on Microcystis aeruginosa in logarithmic growth period could be maintained above 95%. Simultaneous decrease in algal density and chlorophyll-a content indicated that the photosynthesis of algal cells was affected leading to cell death. Significant changes of antioxidant enzyme activities suggested that Microcystis aeruginosa's antioxidant systems had been disrupted. Furthermore, TPSPs increased the concentration of O2- which led to lipid peroxidation of cell membrane and a subsequent increase in malondialdehyde (MDA) content. Meanwhile, the protein content, nucleic acid content, and electrical conductivity in culture medium rose significantly indicating the cell membrane was irreversibly damaged. This work can provide a basis for the utilization of environmentally friendly algal suppressants.

Integrated transcriptomic and metabolomic analysis of Microcystis aeruginosa exposed to artemisinin sustained-release microspheres.

Artemisinin sustained-release microspheres (ASMs) have been shown to inhibit Microcystis aeruginosa (M. aeruginosa) blooms. Previous studies have focused on inhibitory mechanism of ASMs on the physiological level of M. aeruginosa, but the algal inhibitory mechanism of ASMs has not been comprehensively and profoundly revealed. The study proposed to reveal the toxicity mechanism of ASMs on M. aeruginosa based on transcriptomics and metabolomics. After exposure to 0.2 g·L-1 ASMs for 7 days, M. aeruginosa biomass was significantly inhibited, with an inhibition rate (IR) of 47 % on day 7. Transcriptomic and metabolomic results showed that: (1) 478 differentially expressed genes (DEGs) and 251 differential metabolites (DMs) were obtained; (2) ASMs inhibited photosynthesis by blocking photosynthetic pigment synthesis, destroying photoreaction centers and photosynthetic carbon reactions; (3) ASMs reduced L-glutamic acid content and blocked glutathione (GSH) synthesis, leading to an imbalance in the antioxidant system; (4) ASM disrupted nitrogen metabolism and the hindered synthesis of various amino acids; (5) ASMs inhibited glyoxylate cycle and TCA cycle. This study provides an important prerequisite for the practical application of ASMs and a new perspective for the management of harmful algal blooms (HABs).

Effects of Na2CO3/Na2SiO3 Ratio and Curing Temperature on the Structure Formation of Alkali-Activated High-Carbon Biomass Fly Ash Pastes.

This study explored unprocessed high-carbon biomass fly ash (BFA) in alkali-activated materials (AAM) with less alkaline Na2CO3 as the activator. In this paper, the effects of the Na2CO3/Na2SiO3 (C/S) ratio and curing temperature (40 °C and 20 °C) on the setting time, structure formation, product synthesis, and physical-mechanical properties of alkali-activated BFA pastes were systematically investigated. Regardless of curing temperature, increasing the C/S ratio increased the density and compressive strength of the sample while a decrease in water absorption. The higher the curing temperature, the faster the structure evolution during the BFA-based alkaline activation synthesis process and the higher the sample's compressive strength. According to XRD and TG/DTA analyses, the synthesis of gaylussite and C-S-H were observed in the sample with an increasing C/S ratio. The formation of the mentioned minerals contributes to the compressive strength growth of alkali-activated BFA pastes with higher C/S ratios. The findings of this study contribute to the applicability of difficult-to-recycle waste materials such as BFA and the development of sustainable BFA-based AAM.

NNMT-DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition.

Lacking a clear understanding of the molecular mechanism determining cancer cell sensitivity to oxidative phosphorylation (OXPHOS) inhibition limits the development of OXPHOS-targeting cancer treatment. Here, cancer cell lines sensitive or resistant to OXPHOS inhibition are identified by screening. OXPHOS inhibition-sensitive cancer cells possess increased OXPHOS activity and silenced nicotinamide N-methyltransferase (NNMT) expression. NNMT expression negatively correlates with OXPHOS inhibition sensitivity and functionally downregulates the intracellular levels of S-adenosyl methionine (SAM). Expression of DNA methyltransferase 1 (DNMT1), a SAM consumer, positively correlates with OXPHOS inhibition sensitivity. NNMT overexpression and DNMT1 inhibition render OXPHOS inhibition-sensitive cancer cells resistant. Importantly, treatments of OXPHOS inhibitors (Gboxin and Berberine) hamper the growth of mouse tumor xenografts by OXPHOS inhibition sensitive but not resistant cancer cells. What's more, the retrospective study of 62 tumor samples from a clinical trial demonstrates that administration of Berberine reduces the tumor recurrence rate of NNMTlow /DNMT1high but not NNMThigh /DNMT1low colorectal adenomas (CRAs). These results thus reveal a critical role of the NNMT-DNMT1 axis in determining cancer cell reliance on mitochondrial OXPHOS and suggest that NNMT and DNMT1 are faithful biomarkers for OXPHOS-targeting cancer therapies.

A Fully Integrated CMOS-controlled Scalable Microfluidics and Pneumatic-free Cell Actuation and Cytometry Sensing Device.

Moore's law has enabled massive scaling of complex computing and sensing systems in modern-day chip-scale architectures allowing extremely high yield and system complexity at very low-cost. Exploiting such Moore's law, we explore silicon-based integrated circuits and chip-scale systems to interface with biological fluids to manipulate, sense, and detect cells in real-time for an end-to-end low cost, miniaturized, and high sensitivity point-of-care diagnostics platform. Elimi-nating the need for complex, expensive, large and bulky syringe pumps and optical-based cytometers, the proposed system allows pneumatic-free AC electro-osmosis bulk fluid driving capabilities controlled by the CMOS chip, and integrated dielectrophoretic cell actuation with 2µm focusing accuracy, impedance spectroscopy sensing, and separation capabilities. The paper presents, for the first-time, a CMOS-driven cellular sensing platform for microfluidics that can be translated to a wide range of biomedical applications.

Squeezed light generated with hyperradiance without nonlinearity.

We propose that the squeezed light accompanied by hyperradiance is induced by quantum interference in a linear system consisting of a high-quality optical cavity and two coherently driven two-level qubits. When two qubits are placed in the cavity with a distance of integer multiple and one-half of wavelengths (i.e., they have the opposite coupling coefficient to the cavity), we show that squeezed light is generated in the hyperradiance regime under the conditions of strong coupling and weak driving. Simultaneously, Klyshko's criterion alternates up and down at unity when the photon number is even or odd. Moreover, the orthogonal angles of the squeezed light can be controlled by adjusting the frequency detuning between the driving field and the qubits. It can be implemented in a variety of quantum systems, including but not limited to two-level systems such as atoms, ions, quantum dots in single-mode cavities.

Chemotherapeutic nanomaterials in tumor boundary delineation: Prospects for effective tumor treatment.

Accurately delineating tumor boundaries is key to predicting survival rates of cancer patients and assessing response of tumor microenvironment to various therapeutic techniques such as chemotherapy and radiotherapy. This review discusses various strategies that have been deployed to accurately delineate tumor boundaries with particular emphasis on the potential of chemotherapeutic nanomaterials in tumor boundary delineation. It also compiles the types of tumors that have been successfully delineated by currently available strategies. Finally, the challenges that still abound in accurate tumor boundary delineation are presented alongside possible perspective strategies to either ameliorate or solve the problems. It is expected that the information communicated herein will form the first compendious baseline information on tumor boundary delineation with chemotherapeutic nanomaterials and provide useful insights into future possible paths to advancing current available tumor boundary delineation approaches to achieve efficacious tumor therapy.

CMOS-Based Electrokinetic Microfluidics With Multi-Modal Cellular and Bio-Molecular Sensing for End-to-End Point-of-Care System.

The importance of point-of-care (POC) bio-molecular diagnostics capable of rapid analysis has become abundantly evident after the outbreak of the Covid-19 pandemic. While sensing interfaces for both protein and nucleic-acid based assays have been demonstrated with chip-scale systems, sample preparation in compact form factor has often been a major bottleneck in enabling end-to-end POC diagnostics. Miniaturization of an end-to-end system requires addressing the front-end sample processing, without which, the goal for low-cost POC diagnostics remain elusive. In this paper, we address bulk fluid processing with AC-osmotic based electrokinetic fluid flows that can be fully controlled, processed and automated by CMOS ICs, fabricated in TSMC 65 nm LP process. Here, we combine bulk fluid flow control with bio-molecular sensing, cell manipulation, cytometry, and separation-all of which are controlled with silicon chips for an all-in-one bio-sensing device. We show CMOS controlled pneumatic-free bulk fluid flow with fluid velocities reaching up to 160 µm/s within a microfluidic channel of 100 × 50 µm 2 of cross-sectional area. We incorporate electrode arrays to allow precise control and focused cell flows ( ±2 µm precision) for robust cytometry, and for subsequent separation. We also incorporate a 16-element impedance spectroscopy receiver array for cell and label-free protein sensing. The massive scalability of CMOS-driven microfluidics, manipulation, and sensing can lead to a new design space and a new class of miniaturized sensing technologies.

Interaction of two quantum dots mediated by edge modes of coupled-cavity arrays.

Topological photonics is a hot topic in recent years. We combine it with the quantum optics and explore the dynamics of two quantum dots (QDs) separated by the finite coupled-cavity arrays (CCAs). The finite CCAs possessing the alternating hopping strengths will lead to the existence of the topological protected edge modes, also called zero energy modes, when the boundaries leave the weak hopping at two ends. Due to the two edge modes, i.e., symmetric and antisymmetric, with nearly degenerate frequencies, the dynamics of two QDs coupled to the cavities at both ends exhibit complicated behaviors. When the CCAs are composed of a large number of cavities, there are two kinds of phenomena: if the coupling between QDs and cavity is weak, two edge modes will cancel each other out and isolate two QDs deeply; if the coupling between QDs and cavities is large compared with hopping strength, the edge mode disappears and two QDs can be connected through extend modes. Importantly, when the CCAs are formed by a small number of cavities, energy can be transferred to each other between two QDs through the edge modes. Such energy transfer is topologically protected, and the period is long and easily controlled. We also investigate the effects of topologically protected quantum entangled states on such system and find that the quantum entanglement can be well kept or generated for appropriate choices of system parameters and initial states. The investigations enrich the manifestation of topological physics and are helpful to apply the topological protection to quantum computation and quantum communication.

Chiral interaction of an atom in a sandwiched waveguide.

The chiral interaction between light and matter is mainly caused by the spin-momentum locking and makes the chiral quantum optics enter a vigorous development stage. Here, we explore the condition of the perfect chiral interaction between an atom possessing circular dipole and the surface plasmon polariton (SPP) mode. The realization of the perfect chiral interaction must satisfy the following two conditions at the same time. First, the SPP mode should possess the transverse circular polarization; and second, the atom decays mainly into the SPP mode, while the decay through other channel can be ignored. In this paper, we adopt a simple but effective structure to satisfy both of requirements, which is the sandwiched waveguide made of metal. We found that the transverse circular polarization of SPP mode might be achieved within the structure possessing multiple interfaces instead of the interface separating two semi-infinite materials. In our model, the decay rate into SPP mode overwhelms that through traveling wave, which provides higher quantum efficiency. What's more, we found that only the symmetric TM-polarized SPP mode might get the transverse circular polarization. For the sandwiched structure containing metal, the existence of two SPP modes weakens the overall chiral interaction. However, the structure containing left-handed materials (LHMs), which can only support one symmetric TM-polarized SPP mode, can get the nearly perfect chiral interaction. We measure the chiral interaction through the decay rate, radiation field distribution and the unidirectional rate through the energy flux. Our work provides a reference for exploring the perfect chiral interaction in more complex structures and has potential and wide applicability to other optical processes.

Enantioselective Reductive Cyanation and Phosphonylation of Secondary Amides by Iridium and Chiral Thiourea Sequential Catalysis.

The combination of transition-metal catalysis and organocatalysis increasingly offers chemists opportunities to realize diverse unprecedented chemical transformations. By combining iridium with chiral thiourea catalysis, direct enantioselective reductive cyanation and phosphonylation of secondary amides have been accomplished for the first time for the synthesis of enantioenriched chiral α-aminonitriles and α-aminophosphonates. The protocol is highly efficient and enantioselective, providing a novel route to the synthesis of optically active α-functionalized amines from the simple, readily available feedstocks. In addition, the reactions are scalable and the thiourea catalyst can be recycled and reused.

Ten-Gram-Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis.

The market of available contrast agents for clinical magnetic resonance imaging (MRI) has been dominated by gadolinium (Gd) chelates based T1 contrast agents for decades. However, there are growing concerns about their safety because they are retained in the body and are nephrotoxic, which necessitated a warning by the U.S. Food and Drug Administration against the use of such contrast agents. To ameliorate these problems, it is necessary to improve the MRI efficiency of such contrast agents to allow the administration of much reduced dosages. In this study, a ten-gram-scale facile method is developed to synthesize organogadolinium complex nanoparticles (i.e., reductive bovine serum albumin stabilized Gd-salicylate nanoparticles, GdSalNPs-rBSA) with high r1 value of 19.51 mm-1 s-1 and very low r2 /r1 ratio of 1.21 (B0 = 1.5 T) for high-contrast T1 -weighted MRI of tumors. The GdSalNPs-rBSA nanoparticles possess more advantages including low synthesis cost (≈0.54 USD per g), long in vivo circulation time (t1/2 = 6.13 h), almost no Gd3+ release, and excellent biosafety. Moreover, the GdSalNPs-rBSA nanoparticles demonstrate excellent in vivo MRI contrast enhancement (signal-to-noise ratio (ΔSNR) ≈ 220%) for tumor diagnosis.

Complete plastid genome of Suriana maritima L. (Surianaceae) and its implications in phylogenetic reconstruction of Fabales.

The present paper reports for the first time the characteristics of the complete plastid genome of Surianaceae (Suriana maritima L.) in the order Fabales. The circular complete plastid genome is 163,747 bp in length with a typical quadripartite organization containing 115 unique genes, of which 80 are protein-coding genes, 31 tRNA genes and four rRNA genes. The plastid genome of S. maritima is characterized by absence of intron in the atpF gene, which has never been reported for any other species of the Fabales. The gene content and their orders in the plastid genome of Surianaceae are similar to the basal lineages of the legume family (Cercidoideae, Detarioideae) and Quillajaceae, supporting a likely common ancestor for the three families. Phylogenetic analysis supported the sister relationship between Surianaceae and Leguminosae, with strongly supported by Bayesian method and moderately supported by likelihood method. The complete plastid genome of Surianaceae could provide potential benefit in resolving the long-standing unresolved interfamily relationships of Fabales when a more comprehensive sampling from Polygalaceae and Leguminosae is available for future studies.

Single photon polarization conversion via scattering by a pair of atoms.

The single photon scattering in one-dimensional waveguide coupled to two separated atoms is investigated. The first atom is considered as a Λ system and the second one is taken as V -type configuration. The analytical expressions of the single photon scattering spectra are obtained. The calculated results show that the polarization conversion of single photon can be realized by controlling the distance between the two atoms due to the interference effects. The conversion efficiency can reach unit in the ideal case. Furthermore, the polarization conversion of the single photon also depends on the initial state of the Λ system. The influences of dissipations on the single photon polarization conversion are also shown.