1.
Ecotoxicol Environ Saf
; 55(1): 19-23, 2003 May.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12706389
RESUMEN
Cytotoxicity of two insect growth regulators, diflubenzuron, a benzoylphenylurea derivative that inhibits the synthesis of new chitin in target organisms, and pyriproxyfen, an insect juvenile hormone analogue, were tested on CHO-K1 cultures, using the neutral red incorporation assay. Both compounds displayed cytotoxic effects that rise with time exposure. The presence of either fetal calf serum or bovine serum albumin diminished significantly the cytotoxicity of both compounds, thus pointing to a strong protein binding. In addition, extensive metabolization with rat liver submitochondrial fraction gave rise to metabolites less toxic than the parent compounds, implying the relative safety of both diflubenzuron and pyriproxyfen in mammals.
Asunto(s)
Diflubenzurón/toxicidad , Piridinas/toxicidad , Animales , Células CHO , Cricetinae , Diflubenzurón/metabolismo , Relación Dosis-Respuesta a Droga , Hormonas Juveniles , Hígado , Mitocondrias , Unión Proteica , Piridinas/metabolismo , Ratas
2.
Bull Environ Contam Toxicol
; 68(2): 302-8, 2002 Feb.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11815803