RESUMEN
Gelatin is used as an additive in medicine, food, and cosmetics. Gelatin from goatskin is a new excipient that has not been explored by researchers, including for hard-shell capsules. The aim of this study was to evaluate and characterize the hard-shell capsules produced from goatskin gelatin. The goatskin gelatin was extracted by an acid hydrolysis method, and the functional properties were investigated. Hard-shell capsules were then produced from goatskin gelatin, evaluated, and characterized. The gelatin extracted from goatskin had 56.9% ± 0.95 clarity and a pH of 5.11 ± 0.09, 97.51% ± 1.1 protein content, 9.23% ± 0.08 water content, 0.18% ± 0.07 ash content, 2.08% ± 0.35 fat content, gel strength of 298 ± 2.64 gbloom, and viscosity of 27.33 ± 2.07 mPs. The gelatin has met the requirements to be made into hard-shell capsules. The average weight of the hard-shell capsules produced was 96.9 mg with 8.69 standard deviation. The average size of the body and cap length was 18.84 ± 0.64 mm and 10.98 ± 0.30 mm, respectively. The results of capsule evaluation and characterization were as follows: the pH was 4.82 ± 1,27, water content was 10.03 ± 0.21, disintegration time was 4.02 ± 2.09 min, and there was no microbial growth. Thus, the capsules made have met the requirements and can be produced in a large quantity.
RESUMEN
Purpose: This study aims to identify the factors associated with COVID-19 vaccination uptake and the intention to receive the COVID-19 vaccine among Muslim high school students in Jakarta, Indonesia. Patients and Methods: A cross-sectional study using an online survey was conducted for high school students. The population in this study were Muslim students grade 11 and 12 at secondary high school living and studying in Jakarta Metropolitan area. A total of 440 samples have been selected using non-probability sampling. In this study, the independent variables were factors associated with vaccination behaviors that were derived from the HBM and TPB theories, while the dependent variables were vaccination uptake and vaccination intention. Factors associated with the dependent variables have been identified using chi-square and Mann-Whitney tests. Results: About 65% respondents had received COVID-19 vaccine and 72% of those who had not received COVID-19 vaccine had the intention to receive the vaccine. Some of the behavioral model variables such as the perceived susceptibility score, perceived severity score, perceived benefits score, perceived barriers score, self-efficacy score, attitude score, and social norms score were significantly associated with COVID-19 vaccine uptake among high school students. Furthermore, all of the behavioral model variables, ie, perceived susceptibility score, perceived severity score, perceived benefits score, perceived barriers score, cues to action score, self-efficacy score, attitude score, social norms score, and perceived behavioral control score were significantly associated with an intention of being vaccinated. Conclusion: The vaccination for students can be set in more affordable locationsfor example, in schools. In addition, efforts to increase student knowledge regarding the effectiveness and safety of vaccines and the dangers of COVID-19 should be sustained.