RESUMEN
Animal experiments have shown that chronic Opisthorchis invasion results in accelerated continuous blood coagulation, by inducing hypercoagulation and platelet activation. The state of hemostasis depends on the degree of infection and undergoes the largest changes during maximum invasion. Irrespective of invasion rates, chronic opisthorchiasis is accompanied by hypofibrinogenemia.
Asunto(s)
Coagulación Sanguínea , Mesocricetus/sangre , Opistorquiasis/sangre , Opistorquiasis/parasitología , Opisthorchis/crecimiento & desarrollo , Activación Plaquetaria , Animales , Cricetinae , Fibrina/análisis , Fibrinógeno/análisis , Interacciones Huésped-Parásitos , Masculino , Mesocricetus/parasitología , Metacercarias/crecimiento & desarrollo , Opistorquiasis/fisiopatología , Opistorquiasis/veterinaria , Recuento de Huevos de Parásitos , Agregación Plaquetaria , Recuento de PlaquetasRESUMEN
Whether atomic force microscopy might be used for the quantitative assessment of platelet morphofunctional activity was studied. The details of the structure of their surface were found to be better detectable when the platelets were fixed with methanol. The authors show it possible to use atomic force microscopy in the studies of platelet functional activity on the donor platelet concentrate specimens.