Unilateral gamma knife thalamotomy for tremor safety and efficacy in multimodal assessment: a prospective case-control study with two-year follow-up.

INTRODUCTION: Unilateral gamma knife thalamotomy (GKT) is a treatment option for pharmacoresistant tremor of various aetiologies. There have been to date no randomised controlled trials performed to assess its safety and efficacy. Our aim was to summarise a two-year multimodal observation of patients with tremor caused by Parkinson's Disease (PD) or essential tremor (ET). MATERIAL AND METHODS: 23 patients with PD (n = 12) or ET (n = 11) were included. They underwent assessments before, V0 (n = 23), and 12 months, V12 (n = 23), and 24 months, V24 (n = 15), after unilateral GKT. Patients were assessed with psychological tests and acoustic voice analysis. Tremor assessment was performed with a digitising table using the Fahn-Tolosa-Marin rating scale (FTMRS). The Unified Parkinson's Disease rating scale part III (UPDRS-III) was also used in the PD group. Gait and balance was assessed using clinical tests, stabilometric platform, and treadmill. RESULTS: No side effects were observed in a two-year follow-up. There was no notable deterioration observed in the patients' psychological evaluation, speech, or assessment of gait and balance. The scores were significantly lower (p = 0.01) in parts A and B of FTMRS one year after GKT. In post hoc analysis, the scores did not differ significantly between V0 and V24. In FTMRS part C (activities of daily living), no significant change was observed. There was no significant difference in total UPDRS part III score or in score of UPDRS part III domains 3 and 4 ('tremor at rest' and 'action and postural tremor of hands') between measurements. CONCLUSIONS: UGKT may be a safe treatment modality if performed in an experienced centre. Tremor reduction may diminish over time, and UGKT did not lead to cognitive, gait or speech deterioration in a long-term observation.

Investigation of Factors Affecting the Performance of Textronic UHF RFID Transponders.

The aim of this paper is to demonstrate progress in textronic UHF RFID transponder (RFIDtex tag) technology. The fundamental idea behind the RFIDtex tag design involves galvanic separation between circuits of the sewn antenna and the chip, which are electromagnetically coupled through a system of inductive loops. To advance the development of this concept, it is crucial to detect factors affecting the performance of the transponders. To achieve this goal, a mathematical model of the textronic UHF RFID transponder was developed. It involves relationships that describe the impedance of each element, the mutual inductance of the loops, and the chip voltage, and it enables the exploration of the influence of these variables on general parameters such as impedance matching and read range. Various analytical and numerical approaches were considered to obtain the value of the mutual inductance of the loops. The dimensions and geometry of the antenna, as well as the matching circuit in the microelectronic module, were taken into account. Based on the mathematical model, it was determined that mutual inductance strongly affects the chip voltage for frequencies higher than 800 MHz. The calculations from the mathematical model were compared with numerical simulations. Experimental studies were also conducted to investigate how the transponder performance is affected by either the distance between the centers of the loops or the conductivity of the threads used to embroider the antenna. The measurement results allowed us to conclude that even small imperfections in the manufacturing of the transponder, which slightly increase the vertical or horizontal distance between the centers of the loops, cause a dramatic decrease in the mutual inductance and coupling coefficient, significantly impacting the transponder's performance.